GB1445979A - Cephalosporin derivatives - Google Patents

Cephalosporin derivatives

Info

Publication number
GB1445979A
GB1445979A GB4925572A GB4925572A GB1445979A GB 1445979 A GB1445979 A GB 1445979A GB 4925572 A GB4925572 A GB 4925572A GB 4925572 A GB4925572 A GB 4925572A GB 1445979 A GB1445979 A GB 1445979A
Authority
GB
United Kingdom
Prior art keywords
acetamido
phenyl
acylamido
furyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4925572A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB4925572A priority Critical patent/GB1445979A/en
Priority to US05/304,524 priority patent/US3971778A/en
Priority to PH14070A priority patent/PH13762A/en
Priority to JP47114203A priority patent/JPS4972286A/ja
Priority to ES419927A priority patent/ES419927A2/es
Priority to IE190873A priority patent/IE39318B1/xx
Priority to ZA738251A priority patent/ZA738251B/xx
Priority to FR7337851A priority patent/FR2204403B2/fr
Priority to LU68680A priority patent/LU68680A1/xx
Priority to BE137009A priority patent/BE806450R/fr
Priority to US05/587,065 priority patent/US4024137A/en
Priority to US05/618,167 priority patent/US4017515A/en
Priority to US05/668,247 priority patent/US4064346A/en
Publication of GB1445979A publication Critical patent/GB1445979A/en
Priority to US05/762,927 priority patent/US4093803A/en
Priority to US05/762,942 priority patent/US4091209A/en
Priority to US05/762,943 priority patent/US4092477A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
GB4925572A 1971-05-14 1972-10-25 Cephalosporin derivatives Expired GB1445979A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB4925572A GB1445979A (en) 1972-10-25 1972-10-25 Cephalosporin derivatives
US05/304,524 US3971778A (en) 1972-05-12 1972-11-07 Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
PH14070A PH13762A (en) 1971-05-14 1972-11-10 7 beta-acylamido-ceph-3-em-4-carboxylic acid derivatives
JP47114203A JPS4972286A (fr) 1972-10-25 1972-11-14
FR7337851A FR2204403B2 (fr) 1972-10-25 1973-10-24
IE190873A IE39318B1 (en) 1972-10-25 1973-10-24 Cephalosporin derivatives
ZA738251A ZA738251B (en) 1972-10-25 1973-10-24 Improvements in or relating to antibiotics
ES419927A ES419927A2 (es) 1972-10-25 1973-10-24 Procedimiento para la preparacion de derivados de la cefa- losporina.
LU68680A LU68680A1 (fr) 1972-10-25 1973-10-24
BE137009A BE806450R (fr) 1972-10-25 1973-10-24 Perfectionnements relatifs aux antibiotiques
US05/587,065 US4024137A (en) 1971-05-14 1975-06-16 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US05/618,167 US4017515A (en) 1971-05-14 1975-09-30 α-(Etherified oximino) carboxylic acids and acid chlorides
US05/668,247 US4064346A (en) 1971-05-14 1976-03-18 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof
US05/762,927 US4093803A (en) 1971-05-14 1977-01-26 7β-[2-Etherified oximino-2-(thienyl-, furyl- or pyridylacetamido)] cephalosporins
US05/762,942 US4091209A (en) 1971-05-14 1977-01-26 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position
US05/762,943 US4092477A (en) 1971-05-14 1977-01-26 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4925572A GB1445979A (en) 1972-10-25 1972-10-25 Cephalosporin derivatives

Publications (1)

Publication Number Publication Date
GB1445979A true GB1445979A (en) 1976-08-11

Family

ID=10451708

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4925572A Expired GB1445979A (en) 1971-05-14 1972-10-25 Cephalosporin derivatives

Country Status (7)

Country Link
JP (1) JPS4972286A (fr)
BE (1) BE806450R (fr)
ES (1) ES419927A2 (fr)
FR (1) FR2204403B2 (fr)
GB (1) GB1445979A (fr)
LU (1) LU68680A1 (fr)
ZA (1) ZA738251B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
GB2137995A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Benzothienylglycyl cephalosporin derivatives
US7514439B2 (en) 2005-07-11 2009-04-07 Mitsubishi Tanabe Pharma Corporation Oxime derivative and preparations thereof
WO2018053587A1 (fr) * 2016-09-21 2018-03-29 Vectus Biosystems Limited Compositions pour le traitement de l'hypertension et/ou de la fibrose

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144393A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group
US4144392A (en) 1973-12-21 1979-03-13 Glaxo Laboratories Limited Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile
US4165430A (en) 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
FI771866A (fr) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
JPS5818388A (ja) * 1981-07-28 1983-02-02 Banyu Pharmaceut Co Ltd ３−置換チオメチルセフアロスポリン誘導体の製造法
GB8927871D0 (en) * 1989-12-08 1990-02-14 Beecham Group Plc Novel compounds
JP2008019241A (ja) * 2007-03-01 2008-01-31 Mitsubishi Tanabe Pharma Corp オキシム誘導体及びその製法
FR3135420B1 (fr) 2022-05-10 2024-03-29 Psa Automobiles Sa Système de maintien de l’extrémité d’une vis dans un longeron de châssis pour véhicule automobile

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4423213A (en) 1979-11-19 1983-12-27 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4585860A (en) * 1979-11-19 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. 7-acylamino-3-vinylcephalosporanic acid derivatives useful for treatment of infectious diseases in human beings and animals
GB2137995A (en) * 1983-04-12 1984-10-17 Lilly Co Eli Benzothienylglycyl cephalosporin derivatives
US7514439B2 (en) 2005-07-11 2009-04-07 Mitsubishi Tanabe Pharma Corporation Oxime derivative and preparations thereof
US8119626B2 (en) 2005-07-11 2012-02-21 Mitsubishi Tanabe Pharma Corporation Oxime derivative and preparations thereof
WO2018053587A1 (fr) * 2016-09-21 2018-03-29 Vectus Biosystems Limited Compositions pour le traitement de l'hypertension et/ou de la fibrose

Also Published As

Publication number Publication date
ES419927A2 (es) 1976-11-16
JPS4972286A (fr) 1974-07-12
ZA738251B (en) 1974-10-30
BE806450R (fr) 1974-04-24
FR2204403A2 (fr) 1974-05-24
LU68680A1 (fr) 1974-01-08
FR2204403B2 (fr) 1976-12-24

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Legal Events

Date Code Title Description
PS Patent sealed