GB1437783A - 2-substituted biphenylyl acetic acids and derivatives thereof - Google Patents
2-substituted biphenylyl acetic acids and derivatives thereofInfo
- Publication number
- GB1437783A GB1437783A GB4401372A GB4401372A GB1437783A GB 1437783 A GB1437783 A GB 1437783A GB 4401372 A GB4401372 A GB 4401372A GB 4401372 A GB4401372 A GB 4401372A GB 1437783 A GB1437783 A GB 1437783A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetyl
- prepared
- compounds
- conhoh
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 2-substituted biphenylyl acetic acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000007062 hydrolysis Effects 0.000 abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YFVOFFKNHQTQQE-UHFFFAOYSA-N 1-(4-bromo-3-nitrophenyl)ethanone Chemical compound CC(=O)C1=CC=C(Br)C([N+]([O-])=O)=C1 YFVOFFKNHQTQQE-UHFFFAOYSA-N 0.000 abstract 1
- QCZZSANNLWPGEA-UHFFFAOYSA-N 1-(4-phenylphenyl)ethanone Chemical group C1=CC(C(=O)C)=CC=C1C1=CC=CC=C1 QCZZSANNLWPGEA-UHFFFAOYSA-N 0.000 abstract 1
- YKLDMAPEGQYZRT-UHFFFAOYSA-N 2,4-difluoro-1-iodobenzene Chemical compound FC1=CC=C(I)C(F)=C1 YKLDMAPEGQYZRT-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- KOAMXHRRVFDWRQ-UHFFFAOYSA-N 4,4-dimethyl-5h-1,3-oxazole Chemical group CC1(C)COC=N1 KOAMXHRRVFDWRQ-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 238000006887 Ullmann reaction Methods 0.000 abstract 1
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 125000000218 acetic acid group Chemical class C(C)(=O)* 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 abstract 1
- 229940045803 cuprous chloride Drugs 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- 230000003480 fibrinolytic effect Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4401372A GB1437783A (en) | 1972-09-22 | 1972-09-22 | 2-substituted biphenylyl acetic acids and derivatives thereof |
| US05/397,604 US4052514A (en) | 1971-03-26 | 1973-09-14 | Trihalosubstituted biphenylyl propionic acids |
| DE19732347406 DE2347406A1 (de) | 1972-09-22 | 1973-09-20 | 2-substituierte essigsaeuren und deren derivate, diese verbindungen enthaltende mittel und verfahren zur herstellung dieser verbindungen |
| JP10684673A JPS4969641A (enrdf_load_html_response) | 1972-09-22 | 1973-09-21 | |
| FR7334071A FR2295738A1 (fr) | 1972-09-22 | 1973-09-24 | Derives d'acide biphenylylacetique et leurs applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4401372A GB1437783A (en) | 1972-09-22 | 1972-09-22 | 2-substituted biphenylyl acetic acids and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1437783A true GB1437783A (en) | 1976-06-03 |
Family
ID=10431364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4401372A Expired GB1437783A (en) | 1971-03-26 | 1972-09-22 | 2-substituted biphenylyl acetic acids and derivatives thereof |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS4969641A (enrdf_load_html_response) |
| DE (1) | DE2347406A1 (enrdf_load_html_response) |
| FR (1) | FR2295738A1 (enrdf_load_html_response) |
| GB (1) | GB1437783A (enrdf_load_html_response) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7614113A (nl) * | 1976-12-18 | 1978-06-20 | Akzo Nv | Hydroxamzuren. |
| US4173652A (en) * | 1976-12-18 | 1979-11-06 | Akzona Incorporated | Pharmaceutical hydroxamic acid compositions and uses thereof |
| IT1194209B (it) * | 1983-04-21 | 1988-09-14 | Medea Res Srl | Composti fluorurati ad attivita' analgesica e antiinfiammatoria |
| EP0230478B1 (en) * | 1984-09-07 | 1990-04-18 | Nippon Petrochemicals Company, Limited | Method for producing alpha-(p-isobutylphenyl)propionic acid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624142A (en) * | 1964-09-10 | 1971-11-30 | Merck & Co Inc | Substituted biphenyl acetic acid derivatives |
| GB1382996A (en) * | 1971-03-26 | 1975-02-05 | Boots Co Ltd | Substituted biphenyls |
| GB1400448A (en) * | 1971-08-25 | 1975-07-16 | Boots Co Ltd | Oxazoline derivatives arylalkanoic acids their preparation and therapeutic compositions containing them |
-
1972
- 1972-09-22 GB GB4401372A patent/GB1437783A/en not_active Expired
-
1973
- 1973-09-20 DE DE19732347406 patent/DE2347406A1/de active Pending
- 1973-09-21 JP JP10684673A patent/JPS4969641A/ja active Pending
- 1973-09-24 FR FR7334071A patent/FR2295738A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE2347406A1 (de) | 1974-04-11 |
| JPS4969641A (enrdf_load_html_response) | 1974-07-05 |
| FR2295738B1 (enrdf_load_html_response) | 1978-10-20 |
| FR2295738A1 (fr) | 1976-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |