GB1435662A - Bleomycin derivatives - Google Patents

Bleomycin derivatives

Info

Publication number
GB1435662A
GB1435662A GB1233274A GB1233274A GB1435662A GB 1435662 A GB1435662 A GB 1435662A GB 1233274 A GB1233274 A GB 1233274A GB 1233274 A GB1233274 A GB 1233274A GB 1435662 A GB1435662 A GB 1435662A
Authority
GB
United Kingdom
Prior art keywords
bleomycin
amino acid
isotope
march
marked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1233274A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Philips Gloeilampenfabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Gloeilampenfabrieken NV filed Critical Philips Gloeilampenfabrieken NV
Publication of GB1435662A publication Critical patent/GB1435662A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

1435662 Bleomycin derivatives PHILIPS GLOEILAMPENFABRIEKEN NV 20 March 1974 [22 March 1973] 12332/74 Heading C2C Novel bleomycin derivatives consisting of bleomycin coupled via an amido group to an amino acid, the amino acid being marked by a radio-active isotope, are prepared (a) by reacting an amino acid or ester thereof, marked with a radio-active isotope, with bleomycin in an aqueous medium in the presence of a carbodiimide or glutare dialdehyde or (b) by iodizing bleomycin, linked via an amido group to an amino acid containing a phenolic group, with the iodine isotope <SP>123</SP>I, <SP>125</SP>I or <SP>131</SP>I so that at least one atom of the isotope is introduced into the phenyl nucleus of the phenolic group. Injectable compositions for diagnostic examination of tumours comprise a bleomycin derivative as defined above and a suitable liquid carrier.
GB1233274A 1973-03-22 1974-03-20 Bleomycin derivatives Expired GB1435662A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7310292A FR2222103B1 (en) 1973-03-22 1973-03-22

Publications (1)

Publication Number Publication Date
GB1435662A true GB1435662A (en) 1976-05-12

Family

ID=9116691

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1233274A Expired GB1435662A (en) 1973-03-22 1974-03-20 Bleomycin derivatives

Country Status (6)

Country Link
JP (1) JPS5029575A (en)
BE (1) BE812590A (en)
DE (1) DE2413052A1 (en)
FR (1) FR2222103B1 (en)
GB (1) GB1435662A (en)
NL (1) NL7403640A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474746A (en) * 1980-08-08 1984-10-02 State University Of New York Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7801908A (en) * 1978-02-21 1979-08-23 Philips Nv SELENOMETHIONINE-75SE CONTAINING SOLUTION, INCLUDING A THIOL AS A STABILIZER.
JPH0261549A (en) * 1988-08-26 1990-03-01 Nok Corp Manufacture of glucose oxidase immobilized oxygen transmission film

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474746A (en) * 1980-08-08 1984-10-02 State University Of New York Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues

Also Published As

Publication number Publication date
JPS5029575A (en) 1975-03-25
NL7403640A (en) 1974-09-24
BE812590A (en) 1974-09-20
DE2413052A1 (en) 1974-10-03
FR2222103B1 (en) 1976-08-13
FR2222103A1 (en) 1974-10-18

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee