GB1434090A - Halo-4-biphenylyl-butyric acid esters and amides and pharma ceutical compositions containing them - Google Patents

Halo-4-biphenylyl-butyric acid esters and amides and pharma ceutical compositions containing them

Info

Publication number
GB1434090A
GB1434090A GB3884273A GB3884273A GB1434090A GB 1434090 A GB1434090 A GB 1434090A GB 3884273 A GB3884273 A GB 3884273A GB 3884273 A GB3884273 A GB 3884273A GB 1434090 A GB1434090 A GB 1434090A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
compound
reacting
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3884273A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2240441A external-priority patent/DE2240441A1/de
Priority claimed from DE19722261912 external-priority patent/DE2261912A1/de
Priority claimed from DE19732300402 external-priority patent/DE2300402A1/de
Priority claimed from DE19732309914 external-priority patent/DE2309914A1/de
Priority claimed from DE19732322195 external-priority patent/DE2322195A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to BR668474A priority Critical patent/BR7406684D0/pt
Publication of GB1434090A publication Critical patent/GB1434090A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/20Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
    • C07C17/202Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
    • C07C17/208Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64Acyl halides
    • C07C57/76Acyl halides containing halogen outside the carbonyl halide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5407Acyclic saturated phosphonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB3884273A 1972-08-17 1973-08-16 Halo-4-biphenylyl-butyric acid esters and amides and pharma ceutical compositions containing them Expired GB1434090A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR668474A BR7406684D0 (pt) 1973-08-16 1974-08-14 Po contendo cerca de 0,2 a cerca de 5,4% em peso de carbono artigo de substrato metalico superficie trocoide e artigo de composicoa de cromio

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE2240441A DE2240441A1 (de) 1972-08-17 1972-08-17 Neue biphenylderivate und verfahren zur herstellung
DE19722261912 DE2261912A1 (de) 1972-12-18 1972-12-18 Neues verfahren zur herstellung von 3-(4-biphenylyl)-buttersaeuren
DE19732300402 DE2300402A1 (de) 1973-01-05 1973-01-05 Neues verfahren zur herstellung von 3-(4-biphenylyl)-buttersaeuren
DE19732309914 DE2309914A1 (de) 1973-02-28 1973-02-28 Neues verfahren zur herstellung von 3-(4-biphenylyl)-buttersaeuren
DE19732322195 DE2322195A1 (de) 1973-05-03 1973-05-03 Neues verfahren zur herstellung von 3-(4-biphenylyl)-buttersaeuren

Publications (1)

Publication Number Publication Date
GB1434090A true GB1434090A (en) 1976-04-28

Family

ID=27510265

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3884273A Expired GB1434090A (en) 1972-08-17 1973-08-16 Halo-4-biphenylyl-butyric acid esters and amides and pharma ceutical compositions containing them

Country Status (10)

Country Link
JP (1) JPS5525173B2 (US06330241-20011211-M00004.png)
AT (1) ATA785173A (US06330241-20011211-M00004.png)
AU (1) AU476339B2 (US06330241-20011211-M00004.png)
BG (3) BG21846A3 (US06330241-20011211-M00004.png)
DD (2) DD111204A5 (US06330241-20011211-M00004.png)
FR (1) FR2196171B1 (US06330241-20011211-M00004.png)
GB (1) GB1434090A (US06330241-20011211-M00004.png)
HU (1) HU168129B (US06330241-20011211-M00004.png)
IL (1) IL43002A0 (US06330241-20011211-M00004.png)
NL (1) NL7311355A (US06330241-20011211-M00004.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007009389A2 (fr) * 2005-07-22 2007-01-25 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Derives de propanamide substitues, preparation et utilisation de ces derives
CN105061183A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种1-环己烯基乙酸的制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5957870U (ja) * 1982-10-08 1984-04-16 株式会社フジクラ 配線板用接続具
JP2579766B2 (ja) * 1986-05-07 1997-02-12 住友化学工業株式会社 光学活性なビフェニル誘導体およびその製造法
US11844278B2 (en) * 2019-01-23 2023-12-12 Lg Innotek Co., Ltd. Thermoelectric element
JP7345777B2 (ja) * 2019-06-11 2023-09-19 国立大学法人千葉大学 ケトン化合物の製造方法、カルボン酸誘導体の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3385887A (en) * 1961-02-02 1968-05-28 Boots Pure Drug Co Ltd 4-isobutylphenylacetic acid
GB1091403A (en) * 1964-01-24 1967-11-15 Boots Pure Drug Co Ltd Therapeutically active phenylalkane derivatives
FR1545270A (fr) * 1966-11-25 1968-11-08 Boots Pure Drug Co Ltd Procédé de préparation d'acides phénylalcanoïques
NL7203400A (US06330241-20011211-M00004.png) * 1971-03-17 1972-09-19
GB1382996A (en) * 1971-03-26 1975-02-05 Boots Co Ltd Substituted biphenyls
BE787782A (fr) * 1971-08-20 1973-02-19 Thomae Gmbh Dr K Nouveaux 4-(4-biphenylyl)-butyramides
GB1400448A (en) * 1971-08-25 1975-07-16 Boots Co Ltd Oxazoline derivatives arylalkanoic acids their preparation and therapeutic compositions containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007009389A2 (fr) * 2005-07-22 2007-01-25 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Derives de propanamide substitues, preparation et utilisation de ces derives
WO2007009389A3 (fr) * 2005-07-22 2007-04-19 Shanghai Inst Materia Medica Derives de propanamide substitues, preparation et utilisation de ces derives
CN105061183A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种1-环己烯基乙酸的制备方法

Also Published As

Publication number Publication date
IL43002A0 (en) 1973-11-28
BG21010A3 (bg) 1976-01-20
ATA785173A (de) 1975-01-15
FR2196171B1 (US06330241-20011211-M00004.png) 1978-06-30
DD107900A5 (US06330241-20011211-M00004.png) 1974-08-20
BG21846A3 (bg) 1976-09-20
JPS5525173B2 (US06330241-20011211-M00004.png) 1980-07-04
AU5930773A (en) 1975-02-20
FR2196171A1 (US06330241-20011211-M00004.png) 1974-03-15
JPS4980046A (US06330241-20011211-M00004.png) 1974-08-02
DD111204A5 (US06330241-20011211-M00004.png) 1975-02-05
NL7311355A (US06330241-20011211-M00004.png) 1974-02-19
BG21847A3 (bg) 1976-09-20
HU168129B (US06330241-20011211-M00004.png) 1976-02-28
AU476339B2 (en) 1976-09-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees