GB1428431A - Pyrazolidinones - Google Patents
PyrazolidinonesInfo
- Publication number
- GB1428431A GB1428431A GB2217773A GB2217773A GB1428431A GB 1428431 A GB1428431 A GB 1428431A GB 2217773 A GB2217773 A GB 2217773A GB 2217773 A GB2217773 A GB 2217773A GB 1428431 A GB1428431 A GB 1428431A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyrazolidinones
- formula
- substituted
- pyrazolidinone
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NDGRWYRVNANFNB-UHFFFAOYSA-N pyrazolidin-3-one Chemical class O=C1CCNN1 NDGRWYRVNANFNB-UHFFFAOYSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 4
- -1 amine salts Chemical class 0.000 abstract 3
- KLTVSWGXIAYTHO-UHFFFAOYSA-N 1-Octen-3-one Chemical compound CCCCCC(=O)C=C KLTVSWGXIAYTHO-UHFFFAOYSA-N 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- VSMOENVRRABVKN-UHFFFAOYSA-N oct-1-en-3-ol Chemical compound CCCCCC(O)C=C VSMOENVRRABVKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- VSMOENVRRABVKN-MRVPVSSYSA-N 1-Octen-3-ol Natural products CCCCC[C@H](O)C=C VSMOENVRRABVKN-MRVPVSSYSA-N 0.000 abstract 1
- GNGCVMDALBLUSD-UHFFFAOYSA-N 2,2,2-trichloroethyl 3-oxopyrazolidine-1-carboxylate Chemical compound ClC(COC(=O)N1NC(CC1)=O)(Cl)Cl GNGCVMDALBLUSD-UHFFFAOYSA-N 0.000 abstract 1
- YDXQPTHHAPCTPP-UHFFFAOYSA-N 3-Octen-1-ol Natural products CCCCC=CCCO YDXQPTHHAPCTPP-UHFFFAOYSA-N 0.000 abstract 1
- LHVDKPNWJVVYEK-UHFFFAOYSA-N N-(4-chlorophenyl)-2-(3-hydroxyoctyl)-3-oxopyrazolidine-1-carbothioamide Chemical compound OC(CCN1N(CCC1=O)C(NC1=CC=C(C=C1)Cl)=S)CCCCC LHVDKPNWJVVYEK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- AGTCMTUCMQLUMT-UHFFFAOYSA-N benzyl 3-oxopyrazolidine-1-carboxylate Chemical compound C1CC(=O)NN1C(=O)OCC1=CC=CC=C1 AGTCMTUCMQLUMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- NSFWLHKFTGZFBP-UHFFFAOYSA-N dec-1-en-3-ol Chemical compound CCCCCCCC(O)C=C NSFWLHKFTGZFBP-UHFFFAOYSA-N 0.000 abstract 1
- XTDXBZMKUMZNMH-UHFFFAOYSA-N dec-1-en-3-one Chemical compound CCCCCCCC(=O)C=C XTDXBZMKUMZNMH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- VUGRNZHKYVHZSN-UHFFFAOYSA-N oct-1-yn-3-ol Chemical compound CCCCCC(O)C#C VUGRNZHKYVHZSN-UHFFFAOYSA-N 0.000 abstract 1
- OIWBNCGEFFHTNG-UHFFFAOYSA-N oct-1-yn-3-one Chemical compound CCCCCC(=O)C#C OIWBNCGEFFHTNG-UHFFFAOYSA-N 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical class C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25186672A | 1972-05-10 | 1972-05-10 | |
| US33676673A | 1973-02-28 | 1973-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1428431A true GB1428431A (en) | 1976-03-17 |
Family
ID=26941864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2217773A Expired GB1428431A (en) | 1972-05-10 | 1973-05-09 | Pyrazolidinones |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS4961164A (enrdf_load_stackoverflow) |
| DE (1) | DE2323193A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2184064B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1428431A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003410A1 (en) * | 1978-01-23 | 1979-08-08 | Beecham Group Plc | Hydantoins and thiohydantoins, method for their preparation and pharmaceutical compositions containing them |
| WO2003035064A1 (en) * | 2001-10-23 | 2003-05-01 | Applied Research Systems Ars Holding N.V. | Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL53559A0 (en) | 1976-12-18 | 1978-03-10 | Beecham Group Ltd | Novel prostaglandin analogues their preparation and pharmaceutical compositions containing them |
| AU4806879A (en) * | 1978-06-15 | 1979-12-20 | Beecham Group Limited | 1,2,4 triazole derivatives |
| DE2965099D1 (en) * | 1978-06-15 | 1983-05-05 | Beecham Group Plc | Prostaglandin analogue triazole derivatives, processes for their preparation and a pharmaceutical composition containing them |
| AU4778279A (en) * | 1978-06-15 | 1979-12-20 | Beecham Group Limited | Prostaglandin analogues |
| IL57504A0 (en) * | 1978-06-15 | 1979-10-31 | Beecham Group Ltd | Prostagandin analogues,their preparation and pharmaceutical compositions containing |
| US4211876A (en) | 1979-06-13 | 1980-07-08 | E. I. Du Pont De Nemours And Company | 3-Pyrazolidinone carboxamides |
-
1973
- 1973-05-08 DE DE19732323193 patent/DE2323193A1/de not_active Withdrawn
- 1973-05-09 JP JP5156273A patent/JPS4961164A/ja active Pending
- 1973-05-09 GB GB2217773A patent/GB1428431A/en not_active Expired
- 1973-05-10 FR FR7316904A patent/FR2184064B1/fr not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0003410A1 (en) * | 1978-01-23 | 1979-08-08 | Beecham Group Plc | Hydantoins and thiohydantoins, method for their preparation and pharmaceutical compositions containing them |
| WO2003035064A1 (en) * | 2001-10-23 | 2003-05-01 | Applied Research Systems Ars Holding N.V. | Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors |
| AU2002340282B2 (en) * | 2001-10-23 | 2007-08-09 | Merck Serono Sa | Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors |
| US7410991B2 (en) | 2001-10-23 | 2008-08-12 | Laboratoires Serono S.A. | Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors |
| US7863312B2 (en) | 2001-10-23 | 2011-01-04 | Merck Serono Sa | Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2184064A1 (enrdf_load_stackoverflow) | 1973-12-21 |
| FR2184064B1 (enrdf_load_stackoverflow) | 1977-04-22 |
| JPS4961164A (enrdf_load_stackoverflow) | 1974-06-13 |
| DE2323193A1 (de) | 1973-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |