GB1425099A - Psychopharmacologically active peptides - Google Patents
Psychopharmacologically active peptidesInfo
- Publication number
- GB1425099A GB1425099A GB1006273A GB1006273A GB1425099A GB 1425099 A GB1425099 A GB 1425099A GB 1006273 A GB1006273 A GB 1006273A GB 1006273 A GB1006273 A GB 1006273A GB 1425099 A GB1425099 A GB 1425099A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phe
- boc
- lys
- met
- otbu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- -1 Boc Chemical class 0.000 abstract 16
- FADYJNXDPBKVCA-UHFFFAOYSA-N L-Phenylalanyl-L-lysin Natural products NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 abstract 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 5
- 108010018625 phenylalanylarginine Proteins 0.000 abstract 5
- 108010005233 alanylglutamic acid Proteins 0.000 abstract 4
- 108010056582 methionylglutamic acid Proteins 0.000 abstract 4
- 108010072637 phenylalanyl-arginyl-phenylalanine Proteins 0.000 abstract 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 108010002311 N-glycylglutamic acid Proteins 0.000 abstract 2
- XXKULJNZGSAAEW-RYUDHWBXSA-N (2s)-5-[[amino(nitramido)methylidene]amino]-2-[[(2s)-2-amino-3-phenylpropanoyl]amino]pentanoic acid Chemical compound [O-][N+](=O)NC(/N)=N/CCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 XXKULJNZGSAAEW-RYUDHWBXSA-N 0.000 abstract 1
- GNUCSNWOCQFMMC-UFYCRDLUSA-N Phe-Arg-Phe Chemical compound C([C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 GNUCSNWOCQFMMC-UFYCRDLUSA-N 0.000 abstract 1
- GLUBLISJVJFHQS-VIFPVBQESA-N Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CC1=CC=CC=C1 GLUBLISJVJFHQS-VIFPVBQESA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- LRVWQKPBZMUTLZ-IBGZPJMESA-N benzyl 2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]acetate Chemical compound C(C)(C)(C)OC(=O)N[C@H](C(=O)NCC(=O)OCC1=CC=CC=C1)CC1=CC=CC=C1 LRVWQKPBZMUTLZ-IBGZPJMESA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7203042A NL7203042A (enrdf_load_stackoverflow) | 1972-03-08 | 1972-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1425099A true GB1425099A (en) | 1976-02-18 |
Family
ID=19815540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1006273A Expired GB1425099A (en) | 1972-03-08 | 1973-03-01 | Psychopharmacologically active peptides |
Country Status (12)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2560486A4 (en) * | 2010-04-21 | 2014-09-17 | Signature Therapeutics Inc | COMPOSITIONS OF ENZYMSPALTBAR AMPHETAMINE PRODRUGS AND INHIBITORS THEREFOR |
| US12384744B2 (en) | 2021-09-29 | 2025-08-12 | Ensysce Biosciences Inc. | Enzyme-cleavable methadone prodrugs and methods of use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587233A (en) * | 1983-11-07 | 1986-05-06 | Board Of Trustees Of The Leland Stanford Junior University | Use of Arg-Phe-amide derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1301738A (enrdf_load_stackoverflow) * | 1969-07-09 | 1973-01-04 |
-
1972
- 1972-03-08 NL NL7203042A patent/NL7203042A/xx not_active Application Discontinuation
-
1973
- 1973-02-20 ZA ZA731207A patent/ZA731207B/xx unknown
- 1973-02-22 AU AU52511/73A patent/AU471618B2/en not_active Expired
- 1973-03-01 GB GB1006273A patent/GB1425099A/en not_active Expired
- 1973-03-05 HU HUAO352A patent/HU169157B/hu unknown
- 1973-03-06 DE DE19732311099 patent/DE2311099A1/de active Pending
- 1973-03-06 CH CH328873A patent/CH584681A5/xx not_active IP Right Cessation
- 1973-03-07 SE SE7303180A patent/SE406761B/xx unknown
- 1973-03-07 CA CA165,427A patent/CA1025439A/en not_active Expired
- 1973-03-07 JP JP48026885A patent/JPS48103575A/ja active Pending
- 1973-03-08 FR FR7308346A patent/FR2181803B1/fr not_active Expired
- 1973-03-08 BE BE128545A patent/BE796478A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2560486A4 (en) * | 2010-04-21 | 2014-09-17 | Signature Therapeutics Inc | COMPOSITIONS OF ENZYMSPALTBAR AMPHETAMINE PRODRUGS AND INHIBITORS THEREFOR |
| US11179355B2 (en) | 2010-04-21 | 2021-11-23 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| US11400062B2 (en) | 2010-04-21 | 2022-08-02 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| US12384744B2 (en) | 2021-09-29 | 2025-08-12 | Ensysce Biosciences Inc. | Enzyme-cleavable methadone prodrugs and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2311099A1 (de) | 1973-09-13 |
| CH584681A5 (enrdf_load_stackoverflow) | 1977-02-15 |
| BE796478A (fr) | 1973-09-10 |
| JPS48103575A (enrdf_load_stackoverflow) | 1973-12-25 |
| FR2181803A1 (enrdf_load_stackoverflow) | 1973-12-07 |
| NL7203042A (enrdf_load_stackoverflow) | 1973-09-11 |
| CA1025439A (en) | 1978-01-31 |
| ZA731207B (en) | 1973-11-28 |
| SE406761B (sv) | 1979-02-26 |
| FR2181803B1 (enrdf_load_stackoverflow) | 1976-09-03 |
| HU169157B (enrdf_load_stackoverflow) | 1976-10-28 |
| AU5251173A (en) | 1974-08-22 |
| AU471618B2 (en) | 1976-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |