GB1419681A - Aminoalkyl-dibenzocycloheptene derivatives - Google Patents
Aminoalkyl-dibenzocycloheptene derivativesInfo
- Publication number
- GB1419681A GB1419681A GB552973A GB552973A GB1419681A GB 1419681 A GB1419681 A GB 1419681A GB 552973 A GB552973 A GB 552973A GB 552973 A GB552973 A GB 552973A GB 1419681 A GB1419681 A GB 1419681A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- treating
- intermediates
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 8
- 239000000543 intermediate Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 3
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 abstract 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- -1 Aminoalkyl dibenzocycloheptene derivatives Chemical class 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000012442 inert solvent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- QMNXJNURJISYMS-UHFFFAOYSA-N 3-(dimethylamino)-1-phenylpropan-1-one Chemical compound CN(C)CCC(=O)C1=CC=CC=C1 QMNXJNURJISYMS-UHFFFAOYSA-N 0.000 abstract 1
- GDHDASZYFUIDMH-UHFFFAOYSA-N 3-phenylisocoumarin Natural products C=1C2=CC=CC=C2C(=O)OC=1C1=CC=CC=C1 GDHDASZYFUIDMH-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- LSEFCHWGJNHZNT-UHFFFAOYSA-M methyl(triphenyl)phosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C)C1=CC=CC=C1 LSEFCHWGJNHZNT-UHFFFAOYSA-M 0.000 abstract 1
- OABGZRFNYNFHCS-UHFFFAOYSA-N n,2-dimethylbenzamide Chemical compound CNC(=O)C1=CC=CC=C1C OABGZRFNYNFHCS-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- KQYWHJICYXXDSQ-UHFFFAOYSA-M trimethylsulfoxonium chloride Chemical compound [Cl-].C[S+](C)(C)=O KQYWHJICYXXDSQ-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US224323A US3925476A (en) | 1972-02-07 | 1972-02-07 | 10-(2-Dialkylaminoethyl)-10,11-dihydro, or 10-(2-dialkylaminoethyl)-5-methylene-2,7-substituted or unsubstituted-5H-dibenzo{8 a,d{9 cycloheptenes |
| US30830272A | 1972-11-20 | 1972-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1419681A true GB1419681A (en) | 1975-12-31 |
Family
ID=26918615
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB552973A Expired GB1419681A (en) | 1972-02-07 | 1973-02-05 | Aminoalkyl-dibenzocycloheptene derivatives |
| GB2823775A Expired GB1419682A (en) | 1972-02-07 | 1973-02-05 | Aminoalkyldibenzocyclohepten-5-one derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2823775A Expired GB1419682A (en) | 1972-02-07 | 1973-02-05 | Aminoalkyldibenzocyclohepten-5-one derivatives |
Country Status (15)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003104216A1 (en) * | 2002-06-10 | 2003-12-18 | Acadia Pharmaceuticals Inc. | Urotensin ii receptor modulators |
-
0
- BE BE795003D patent/BE795003A/xx unknown
-
1973
- 1973-01-26 CH CH113573A patent/CH583168A5/xx not_active IP Right Cessation
- 1973-01-31 SE SE7301324A patent/SE402763B/xx unknown
- 1973-02-02 SU SU1878869A patent/SU495823A3/ru active
- 1973-02-02 NL NL7301508A patent/NL7301508A/xx not_active Application Discontinuation
- 1973-02-03 DE DE2305456A patent/DE2305456A1/de active Pending
- 1973-02-05 GB GB552973A patent/GB1419681A/en not_active Expired
- 1973-02-05 GB GB2823775A patent/GB1419682A/en not_active Expired
- 1973-02-05 ES ES411318A patent/ES411318A1/es not_active Expired
- 1973-02-05 DD DD174059A patent/DD108739A5/xx unknown
- 1973-02-05 CA CA162,918A patent/CA1003828A/en not_active Expired
- 1973-02-05 DD DD168731A patent/DD103888A5/xx unknown
- 1973-02-05 HU HUSA2455A patent/HU164967B/hu unknown
- 1973-02-05 AT AT101073A patent/AT337154B/de not_active IP Right Cessation
- 1973-02-06 PL PL1973160613A patent/PL87769B1/pl unknown
- 1973-02-06 FR FR7304092A patent/FR2183664B1/fr not_active Expired
- 1973-02-06 JP JP48014348A patent/JPS4891048A/ja active Pending
- 1973-05-25 BE BE131562A patent/BE800079R/xx active
-
1975
- 1975-11-04 SE SE7512324A patent/SE7512324L/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003104216A1 (en) * | 2002-06-10 | 2003-12-18 | Acadia Pharmaceuticals Inc. | Urotensin ii receptor modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2183664A1 (enrdf_load_html_response) | 1973-12-21 |
| ATA101073A (de) | 1976-10-15 |
| JPS4891048A (enrdf_load_html_response) | 1973-11-27 |
| SE7512324L (sv) | 1975-11-04 |
| SE402763B (sv) | 1978-07-17 |
| FR2183664B1 (enrdf_load_html_response) | 1976-12-03 |
| ES411318A1 (es) | 1976-04-01 |
| PL87769B1 (en) | 1976-07-31 |
| CA1003828A (en) | 1977-01-18 |
| DD103888A5 (enrdf_load_html_response) | 1974-02-12 |
| DE2305456A1 (de) | 1973-08-16 |
| HU164967B (enrdf_load_html_response) | 1974-05-28 |
| BE795003A (fr) | 1973-08-06 |
| BE800079R (fr) | 1973-11-26 |
| CH583168A5 (enrdf_load_html_response) | 1976-12-31 |
| AT337154B (de) | 1977-06-10 |
| NL7301508A (enrdf_load_html_response) | 1973-08-09 |
| SU495823A3 (ru) | 1975-12-15 |
| GB1419682A (en) | 1975-12-31 |
| DD108739A5 (enrdf_load_html_response) | 1974-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |