GB1409865A - Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them - Google Patents

Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them

Info

Publication number
GB1409865A
GB1409865A GB703773A GB703773A GB1409865A GB 1409865 A GB1409865 A GB 1409865A GB 703773 A GB703773 A GB 703773A GB 703773 A GB703773 A GB 703773A GB 1409865 A GB1409865 A GB 1409865A
Authority
GB
United Kingdom
Prior art keywords
radical
compound
alkyl radical
lower alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB703773A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB703773A priority Critical patent/GB1409865A/en
Priority to DE19742462086 priority patent/DE2462086A1/de
Priority to DE19742405658 priority patent/DE2405658A1/de
Priority to NL7401914A priority patent/NL7401914A/xx
Priority to ES423155A priority patent/ES423155A1/es
Priority to JP49017072A priority patent/JPS5112632B2/ja
Priority to BE140823A priority patent/BE810921A/fr
Priority to CA192,447A priority patent/CA1061346A/fr
Priority to FR7404586A priority patent/FR2217016B1/fr
Priority to SU7401999280A priority patent/SU575025A3/ru
Publication of GB1409865A publication Critical patent/GB1409865A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB703773A 1973-02-13 1973-02-13 Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them Expired GB1409865A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB703773A GB1409865A (en) 1973-02-13 1973-02-13 Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
DE19742462086 DE2462086A1 (de) 1973-02-13 1974-02-06 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE19742405658 DE2405658A1 (de) 1973-02-13 1974-02-06 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
NL7401914A NL7401914A (fr) 1973-02-13 1974-02-12
ES423155A ES423155A1 (es) 1973-02-13 1974-02-12 Procedimiento de obtencion de nuevas 4-aril 1,4-dihidropi- ridinas.
JP49017072A JPS5112632B2 (fr) 1973-02-13 1974-02-12
BE140823A BE810921A (fr) 1973-02-13 1974-02-12 Nouvelles dihydropyridines
CA192,447A CA1061346A (fr) 1973-02-13 1974-02-12 Procede d'obtention de nouvelles dihydropyridines
FR7404586A FR2217016B1 (fr) 1973-02-13 1974-02-12
SU7401999280A SU575025A3 (ru) 1973-02-13 1974-02-12 Способ получени 4-арил-1,4-дигидропиридинов или их солей

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB703773A GB1409865A (en) 1973-02-13 1973-02-13 Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them

Publications (1)

Publication Number Publication Date
GB1409865A true GB1409865A (en) 1975-10-15

Family

ID=9825435

Family Applications (1)

Application Number Title Priority Date Filing Date
GB703773A Expired GB1409865A (en) 1973-02-13 1973-02-13 Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them

Country Status (9)

Country Link
JP (1) JPS5112632B2 (fr)
BE (1) BE810921A (fr)
CA (1) CA1061346A (fr)
DE (2) DE2405658A1 (fr)
ES (1) ES423155A1 (fr)
FR (1) FR2217016B1 (fr)
GB (1) GB1409865A (fr)
NL (1) NL7401914A (fr)
SU (1) SU575025A3 (fr)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2156809A (en) * 1984-03-27 1985-10-16 Invest Y Desarrolo Quimico Bio 1,4-dihydropyridine derivatives, their preparations and their use
WO1986004581A1 (fr) * 1985-02-11 1986-08-14 Imperial Chemical Industries Plc Dihydropyridines alcanolamines
EP0194048A1 (fr) * 1985-02-11 1986-09-10 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194047A1 (fr) * 1985-02-11 1986-09-10 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194046A1 (fr) * 1985-02-11 1986-09-10 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194752A1 (fr) * 1985-02-11 1986-09-17 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0194751A1 (fr) * 1985-02-11 1986-09-17 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0245918A1 (fr) * 1986-02-20 1987-11-19 GLAXO S.p.A. Dérivés de la dihydro-1,4 pyridine
US4801599A (en) * 1984-08-22 1989-01-31 Glaxo S.P.A. 1,4-dihydropyridines
US4806533A (en) * 1986-02-20 1989-02-21 Glaxo, S.P.A. 1,4-Dihydro pyridine 3,5 dicarboxylic acid derivatives and compositions
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
WO1998007698A1 (fr) * 1996-08-23 1998-02-26 Lusochimica S.P.A. Procede pour la preparation de dihydropiridines
US9447071B2 (en) 2014-02-07 2016-09-20 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9776960B2 (en) 2013-03-15 2017-10-03 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9981939B2 (en) 2013-03-15 2018-05-29 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10017491B2 (en) 2013-03-15 2018-07-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10034879B2 (en) 2011-12-28 2018-07-31 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
US10077249B2 (en) 2016-05-12 2018-09-18 Global Blood Therapeutics, Inc. Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US10100040B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10377741B2 (en) 2011-12-28 2019-08-13 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US10450269B1 (en) 2013-11-18 2019-10-22 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10493035B2 (en) 2016-10-12 2019-12-03 Global Blood Therapeutics, Inc. Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US11053195B2 (en) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US11236109B2 (en) 2013-03-15 2022-02-01 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5046994U (fr) * 1973-08-29 1975-05-10
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS5822679Y2 (ja) * 1980-11-07 1983-05-14 有限会社 米田製作所 面体清掃具
US4458099A (en) * 1981-03-19 1984-07-03 Hitachi, Ltd. Three-phase combined type gas insulated electrical apparatus
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
JPS60143511A (ja) * 1983-12-29 1985-07-29 スタツクス工業株式会社 マイクロフォンのシールド装置
GB2181127B (en) * 1985-08-21 1989-08-02 Glaxo Spa 4-phenyl-dihydropyridine carboxylic acid derivatives
EP0226271B1 (fr) * 1985-08-21 1990-11-22 GLAXO S.p.A. Dihydro-1,4 pyridines, leur préparation et composition pharmaceutique
DE3544211A1 (de) * 1985-12-13 1987-06-19 Bayer Ag Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GR1002248B (en) * 1988-03-08 1996-04-23 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydropyridine derivatives preparation method
EP0461264A4 (en) * 1989-12-29 1992-02-19 Kaken Pharmaceutical Co., Ltd. Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient
AU8430098A (en) * 1998-07-23 2000-02-14 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2156809A (en) * 1984-03-27 1985-10-16 Invest Y Desarrolo Quimico Bio 1,4-dihydropyridine derivatives, their preparations and their use
US4801599A (en) * 1984-08-22 1989-01-31 Glaxo S.P.A. 1,4-dihydropyridines
US4873254A (en) * 1985-02-11 1989-10-10 Imperial Chemical Industries Plc 1,4-Dihydropyridines substituted by 3-aryloxy-2-hydroxypropyl amino moiety in the 4-phenyl group
WO1986004581A1 (fr) * 1985-02-11 1986-08-14 Imperial Chemical Industries Plc Dihydropyridines alcanolamines
EP0194048A1 (fr) * 1985-02-11 1986-09-10 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194047A1 (fr) * 1985-02-11 1986-09-10 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194046A1 (fr) * 1985-02-11 1986-09-10 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194750A1 (fr) * 1985-02-11 1986-09-17 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et compositions pharmaceutiques les contenant
EP0194752A1 (fr) * 1985-02-11 1986-09-17 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0194751A1 (fr) * 1985-02-11 1986-09-17 Imperial Chemical Industries Plc Dihydropyridine alkanolamines, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0245918A1 (fr) * 1986-02-20 1987-11-19 GLAXO S.p.A. Dérivés de la dihydro-1,4 pyridine
US4806533A (en) * 1986-02-20 1989-02-21 Glaxo, S.P.A. 1,4-Dihydro pyridine 3,5 dicarboxylic acid derivatives and compositions
US4946851A (en) * 1986-02-20 1990-08-07 Glaxo, S.P.A. 1.4-dihydropyridines
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
WO1998007698A1 (fr) * 1996-08-23 1998-02-26 Lusochimica S.P.A. Procede pour la preparation de dihydropiridines
US10806733B2 (en) 2011-12-28 2020-10-20 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
US10822326B2 (en) 2011-12-28 2020-11-03 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US10034879B2 (en) 2011-12-28 2018-07-31 Global Blood Therapeutics, Inc. Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
US10377741B2 (en) 2011-12-28 2019-08-13 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9981939B2 (en) 2013-03-15 2018-05-29 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US11236109B2 (en) 2013-03-15 2022-02-01 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US10100040B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US11053195B2 (en) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10017491B2 (en) 2013-03-15 2018-07-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10315991B2 (en) 2013-03-15 2019-06-11 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10435393B2 (en) 2013-03-15 2019-10-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US11530191B2 (en) 2013-03-15 2022-12-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10858317B2 (en) 2013-03-15 2020-12-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10829470B2 (en) 2013-03-15 2020-11-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9776960B2 (en) 2013-03-15 2017-10-03 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10450269B1 (en) 2013-11-18 2019-10-22 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10722502B2 (en) 2014-02-07 2020-07-28 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US10137118B2 (en) 2014-02-07 2018-11-27 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US11452720B2 (en) 2014-02-07 2022-09-27 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US9447071B2 (en) 2014-02-07 2016-09-20 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US11944612B2 (en) 2015-12-04 2024-04-02 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US10577345B2 (en) 2016-05-12 2020-03-03 Global Blood Therapeutics, Inc. Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
US10077249B2 (en) 2016-05-12 2018-09-18 Global Blood Therapeutics, Inc. Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
US10493035B2 (en) 2016-10-12 2019-12-03 Global Blood Therapeutics, Inc. Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

Also Published As

Publication number Publication date
JPS5112632B2 (fr) 1976-04-21
SU575025A3 (ru) 1977-09-30
DE2462086A1 (de) 1975-10-23
CA1061346A (fr) 1979-08-28
JPS5040576A (fr) 1975-04-14
BE810921A (fr) 1974-08-12
FR2217016A1 (fr) 1974-09-06
ES423155A1 (es) 1976-10-16
FR2217016B1 (fr) 1977-07-01
DE2405658A1 (de) 1974-08-29
NL7401914A (fr) 1974-08-15

Similar Documents

Publication Publication Date Title
GB1409865A (en) Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
GB1424572A (en) 3,4-dihydrocarbostyril derivatives and their preparation
GB1489280A (en) Indazole derivatives
GB1263987A (en) Phenethylamine derivatives
GB1351501A (en) Adenosine derivatives and the production thereof
GB1369379A (en) Benzodioxole derivatives and processes for preparing them
GB1481813A (en) Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
GB1439724A (en) Berbine derivatives and pharmaceutical compositions containing them
GB1367785A (en) 2-substituted adenosine derivatives and the production thereof
GB1436533A (en) Aryl piperazine derivatives of adenine
GB1395563A (en) 5-nitrofuryl pyridine derivatives
GB1421714A (en) Tricyclic arylalkylene lactimimides
GB1495305A (en) 3-phenyl-4-oxo-4h-benzopyran derivatives
GB1513446A (en) 1,2-benzisoxazole derivatives
GB1501149A (en) Isocarbostyril derivatives
GB1506816A (en) Prostaglandins
GB1436307A (en) Diaromatic o-aminoalkyl-oximes
GB1399261A (en) 1,3-diamino 2-propanols and process for their preparation
ES363655A1 (es) Procedimiento de preparacion de (p-fluoro butiro fenonil)-1piperazinas.
GB1468129A (en) Triazoles and imidazoles
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
GB1305458A (fr)
GB1461667A (en) Amphetamine derivatives
GB1511736A (en) Amidino-hydrazone derivatives of benzocycloalkanones
GB1381833A (en) Amino acid derivatives

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee