GB1409387A - Process for preparing 5-fluorocytidine - Google Patents
Process for preparing 5-fluorocytidineInfo
- Publication number
- GB1409387A GB1409387A GB5481173A GB5481173A GB1409387A GB 1409387 A GB1409387 A GB 1409387A GB 5481173 A GB5481173 A GB 5481173A GB 5481173 A GB5481173 A GB 5481173A GB 1409387 A GB1409387 A GB 1409387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluorocytidine
- fluorinated
- nov
- esters
- acyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- STRZQWQNZQMHQR-UAKXSSHOSA-N 5-fluorocytidine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 STRZQWQNZQMHQR-UAKXSSHOSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229950000242 ancitabine Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Chemical class 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11856772A JPS5545560B2 (enrdf_load_stackoverflow) | 1972-11-28 | 1972-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1409387A true GB1409387A (en) | 1975-10-08 |
Family
ID=14739780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5481173A Expired GB1409387A (en) | 1972-11-28 | 1973-11-26 | Process for preparing 5-fluorocytidine |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5545560B2 (enrdf_load_stackoverflow) |
| DE (1) | DE2359108A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2213282A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1409387A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5424993Y2 (enrdf_load_stackoverflow) * | 1974-06-28 | 1979-08-22 | ||
| JPS52153977A (en) * | 1976-06-11 | 1977-12-21 | Daikin Ind Ltd | Synthesis of 5-fluorouracil and its derivatives |
| US4071680A (en) * | 1976-12-20 | 1978-01-31 | Hoffmann-La Roche Inc. | 5'-Deoxy-5-fluoropyrimidine nucleosides |
-
1972
- 1972-11-28 JP JP11856772A patent/JPS5545560B2/ja not_active Expired
-
1973
- 1973-11-26 GB GB5481173A patent/GB1409387A/en not_active Expired
- 1973-11-27 DE DE19732359108 patent/DE2359108A1/de active Pending
- 1973-11-28 FR FR7342398A patent/FR2213282A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE2359108A1 (de) | 1974-05-30 |
| FR2213282A1 (enrdf_load_stackoverflow) | 1974-08-02 |
| JPS5545560B2 (enrdf_load_stackoverflow) | 1980-11-18 |
| JPS4976881A (enrdf_load_stackoverflow) | 1974-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |