GB1394231A - Process for the production of pepstatins having anti-pepsin activity - Google Patents

Process for the production of pepstatins having anti-pepsin activity

Info

Publication number
GB1394231A
GB1394231A GB1088772A GB1088772A GB1394231A GB 1394231 A GB1394231 A GB 1394231A GB 1088772 A GB1088772 A GB 1088772A GB 1088772 A GB1088772 A GB 1088772A GB 1394231 A GB1394231 A GB 1394231A
Authority
GB
United Kingdom
Prior art keywords
atcc
march
salts
pepstatins
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1088772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of GB1394231A publication Critical patent/GB1394231A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1394231 Pepsin inhibitors ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYO KAI 8 March 1972 [26 March 1971] 10887/72 Heading C2C [Also in Division C3] Novel compounds of the Formula I wherein R is n-hexanoyl or isohexanoyl and C 1-4 alkyl esters and salts thereof are prepared by cultivating under aerobic conditions Streptomyces testaceus (ATCC No. 21467) or Steptomyces argenteolus var. toyonakensia (ATCC No. 21468) and, if desired, converting the resulting acids into esters or salts.
GB1088772A 1971-03-26 1972-03-08 Process for the production of pepstatins having anti-pepsin activity Expired GB1394231A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1729271A JPS547876B1 (en) 1971-03-26 1971-03-26

Publications (1)

Publication Number Publication Date
GB1394231A true GB1394231A (en) 1975-05-14

Family

ID=11939901

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1088772A Expired GB1394231A (en) 1971-03-26 1972-03-08 Process for the production of pepstatins having anti-pepsin activity

Country Status (27)

Country Link
JP (1) JPS547876B1 (en)
AT (1) AT316463B (en)
BE (1) BE781253A (en)
BG (2) BG20616A3 (en)
CA (1) CA976899A (en)
CH (1) CH577557A5 (en)
CS (1) CS174828B2 (en)
DE (1) DE2213674C3 (en)
DK (1) DK131792C (en)
EG (1) EG10462A (en)
ES (1) ES400777A1 (en)
FI (1) FI48474C (en)
FR (1) FR2130730B1 (en)
GB (1) GB1394231A (en)
HU (1) HU166530B (en)
IE (1) IE36183B1 (en)
IL (1) IL38954A (en)
LU (1) LU65036A1 (en)
NL (1) NL165501C (en)
NO (1) NO136051C (en)
PH (1) PH10703A (en)
PL (1) PL88968B1 (en)
RO (1) RO62299A (en)
SE (1) SE399909B (en)
SU (1) SU588927A3 (en)
YU (1) YU35274B (en)
ZA (1) ZA721668B (en)

Also Published As

Publication number Publication date
IL38954A (en) 1974-10-22
FR2130730B1 (en) 1975-03-21
YU79572A (en) 1980-04-30
BG20616A3 (en) 1975-12-05
YU35274B (en) 1980-10-31
CS174828B2 (en) 1977-04-29
ZA721668B (en) 1972-12-27
HU166530B (en) 1975-03-28
CH577557A5 (en) 1976-07-15
ES400777A1 (en) 1975-11-01
BE781253A (en) 1972-09-25
DE2213674C3 (en) 1978-04-27
LU65036A1 (en) 1972-07-11
IL38954A0 (en) 1972-05-30
BG19809A3 (en) 1975-10-10
NL7204068A (en) 1972-09-28
NO136051C (en) 1977-07-13
RO62299A (en) 1978-02-15
PH10703A (en) 1977-08-24
PL88968B1 (en) 1976-10-30
IE36183B1 (en) 1976-09-01
SU588927A3 (en) 1978-01-15
FI48474C (en) 1974-10-10
EG10462A (en) 1976-11-30
NO136051B (en) 1977-04-04
CA976899A (en) 1975-10-28
SE399909B (en) 1978-03-06
JPS547876B1 (en) 1979-04-10
DE2213674A1 (en) 1972-10-26
DE2213674B2 (en) 1977-09-01
DK131792C (en) 1976-03-29
FR2130730A1 (en) 1972-11-03
IE36183L (en) 1972-09-26
FI48474B (en) 1974-07-01
AT316463B (en) 1974-07-10
NL165501C (en) 1981-04-15
DK131792B (en) 1975-09-01

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee