ES400777A1 - Process for the production of pepstatins having anti-pepsin activity - Google Patents
Process for the production of pepstatins having anti-pepsin activityInfo
- Publication number
- ES400777A1 ES400777A1 ES400777A ES400777A ES400777A1 ES 400777 A1 ES400777 A1 ES 400777A1 ES 400777 A ES400777 A ES 400777A ES 400777 A ES400777 A ES 400777A ES 400777 A1 ES400777 A1 ES 400777A1
- Authority
- ES
- Spain
- Prior art keywords
- pepstatin
- caproyl
- syrup
- pepstatins
- atcc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
Abstract
A process for the production of new pepstatins, which act as pepsin inhibitors and having the formula; **(See formula)** where R is an n-caproyl radial in the case of "pepstatin" B, or it is an iso-caproyl radical in the case of pepstatin C or an alkyl ester thereof, with the alkyl group having 1-4 atoms carbon, characterized in that a pepstatin-producing specimen of Streptomyces testaceus ATCC No. 21469, or of Streptomyces argenteolus var. toyonaekensis ATCC No. 21469 is grown in a nutrient medium containing assimilable nitrogen and carbon sources for 3-10 days under aerobic conditions, the culture medium is extracted with n-butanol, the extract is concentrated to a syrup, precipitation is carried out By adding water to said syrup, the pepstatin derivatives thus precipitated are recovered and purified with the help of methyl esterification and later, if desired, are converted into their respective esters or alkaline salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1729271A JPS547876B1 (en) | 1971-03-26 | 1971-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES400777A1 true ES400777A1 (en) | 1975-11-01 |
Family
ID=11939901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES400777A Expired ES400777A1 (en) | 1971-03-26 | 1972-03-15 | Process for the production of pepstatins having anti-pepsin activity |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS547876B1 (en) |
| AT (1) | AT316463B (en) |
| BE (1) | BE781253A (en) |
| BG (2) | BG19809A3 (en) |
| CA (1) | CA976899A (en) |
| CH (1) | CH577557A5 (en) |
| CS (1) | CS174828B2 (en) |
| DE (1) | DE2213674C3 (en) |
| DK (1) | DK131792C (en) |
| EG (1) | EG10462A (en) |
| ES (1) | ES400777A1 (en) |
| FI (1) | FI48474C (en) |
| FR (1) | FR2130730B1 (en) |
| GB (1) | GB1394231A (en) |
| HU (1) | HU166530B (en) |
| IE (1) | IE36183B1 (en) |
| IL (1) | IL38954A (en) |
| LU (1) | LU65036A1 (en) |
| NL (1) | NL165501C (en) |
| NO (1) | NO136051C (en) |
| PH (1) | PH10703A (en) |
| PL (1) | PL88968B1 (en) |
| RO (1) | RO62299A (en) |
| SE (1) | SE399909B (en) |
| SU (1) | SU588927A3 (en) |
| YU (1) | YU35274B (en) |
| ZA (1) | ZA721668B (en) |
-
1971
- 1971-03-24 PH PH13386A patent/PH10703A/en unknown
- 1971-03-26 JP JP1729271A patent/JPS547876B1/ja active Pending
-
1972
- 1972-03-08 GB GB1088772A patent/GB1394231A/en not_active Expired
- 1972-03-10 ZA ZA721668A patent/ZA721668B/en unknown
- 1972-03-10 IL IL38954A patent/IL38954A/en unknown
- 1972-03-12 EG EG98/72A patent/EG10462A/en active
- 1972-03-15 ES ES400777A patent/ES400777A1/en not_active Expired
- 1972-03-20 CH CH410972A patent/CH577557A5/xx not_active IP Right Cessation
- 1972-03-20 IE IE351/72A patent/IE36183B1/en unknown
- 1972-03-21 CS CS1889A patent/CS174828B2/cs unknown
- 1972-03-21 RO RO7200070202A patent/RO62299A/en unknown
- 1972-03-21 DE DE2213674A patent/DE2213674C3/en not_active Expired
- 1972-03-22 SU SU721762234A patent/SU588927A3/en active
- 1972-03-24 CA CA138,010A patent/CA976899A/en not_active Expired
- 1972-03-24 BE BE781253A patent/BE781253A/en not_active IP Right Cessation
- 1972-03-24 YU YU795/72A patent/YU35274B/en unknown
- 1972-03-24 NO NO1010/72A patent/NO136051C/en unknown
- 1972-03-24 FR FR7211143A patent/FR2130730B1/fr not_active Expired
- 1972-03-24 HU HUZA343A patent/HU166530B/hu unknown
- 1972-03-24 LU LU65036D patent/LU65036A1/xx unknown
- 1972-03-24 DK DK144272A patent/DK131792C/en active
- 1972-03-25 PL PL1972154328A patent/PL88968B1/pl unknown
- 1972-03-27 BG BG020069A patent/BG19809A3/en unknown
- 1972-03-27 BG BG23999A patent/BG20616A3/xx unknown
- 1972-03-27 AT AT264572A patent/AT316463B/en not_active IP Right Cessation
- 1972-03-27 SE SE7203975A patent/SE399909B/en unknown
- 1972-03-27 FI FI720847A patent/FI48474C/en active
- 1972-08-25 NL NL7204068.A patent/NL165501C/en not_active IP Right Cessation
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