GB1393161A - Thieno 3,2-d pyrimidines - Google Patents
Thieno 3,2-d pyrimidinesInfo
- Publication number
- GB1393161A GB1393161A GB2058472A GB2058472A GB1393161A GB 1393161 A GB1393161 A GB 1393161A GB 2058472 A GB2058472 A GB 2058472A GB 2058472 A GB2058472 A GB 2058472A GB 1393161 A GB1393161 A GB 1393161A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- thiomorpholino
- carbon atoms
- substituted
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003230 pyrimidines Chemical class 0.000 title 1
- -1 piperazino group Chemical group 0.000 abstract 9
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- VFCRIUBJHGQFGO-UHFFFAOYSA-N 4-(2-chloro-6-nitrothieno[3,2-d]pyrimidin-4-yl)morpholine Chemical compound ClC=1N=C(C2=C(N1)C=C(S2)[N+](=O)[O-])N2CCOCC2 VFCRIUBJHGQFGO-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- ZYCTWTOZQBKDND-UHFFFAOYSA-N ethyl 4-thieno[3,2-d]pyrimidin-2-ylpiperazine-1-carboxylate Chemical compound C(=O)(OCC)N1CCN(CC1)C1=NC2=C(C=N1)SC=C2 ZYCTWTOZQBKDND-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712121950 DE2121950A1 (en) | 1971-05-04 | 1971-05-04 | Thieno(3,2-d)pyrimidine derivs - with thrombocyte aggregation inhibiting activity |
| DE19712137341 DE2137341A1 (de) | 1971-07-26 | 1971-07-26 | Neue thieno eckige klammer auf 3,2-d eckige klammer zu pyrimidine |
| DE19722215299 DE2215299A1 (de) | 1972-03-29 | 1972-03-29 | Neue thieno eckige klammer auf 3,2-d eckige klammer zu pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1393161A true GB1393161A (en) | 1975-05-07 |
Family
ID=27183398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2058472A Expired GB1393161A (en) | 1971-05-04 | 1972-05-03 | Thieno 3,2-d pyrimidines |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3888851A (cg-RX-API-DMAC7.html) |
| AT (1) | AT318619B (cg-RX-API-DMAC7.html) |
| AU (1) | AU4181572A (cg-RX-API-DMAC7.html) |
| BE (1) | BE783044A (cg-RX-API-DMAC7.html) |
| BG (1) | BG20593A3 (cg-RX-API-DMAC7.html) |
| DD (1) | DD97656A5 (cg-RX-API-DMAC7.html) |
| DK (1) | DK129844B (cg-RX-API-DMAC7.html) |
| ES (1) | ES402302A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2135294B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1393161A (cg-RX-API-DMAC7.html) |
| HU (1) | HU163960B (cg-RX-API-DMAC7.html) |
| IL (1) | IL39341A (cg-RX-API-DMAC7.html) |
| NL (1) | NL7206041A (cg-RX-API-DMAC7.html) |
| PL (1) | PL82381B1 (cg-RX-API-DMAC7.html) |
| RO (1) | RO62428A (cg-RX-API-DMAC7.html) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009042607A1 (en) | 2007-09-24 | 2009-04-02 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
| US7750002B2 (en) | 2004-10-25 | 2010-07-06 | Piramed Limited | Pharmaceutical compounds |
| US7781433B2 (en) | 2006-04-26 | 2010-08-24 | Piramed Limited | Pharmaceutical compounds |
| WO2010105008A2 (en) | 2009-03-12 | 2010-09-16 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies |
| WO2010138589A1 (en) | 2009-05-27 | 2010-12-02 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| US7846929B2 (en) | 2006-04-26 | 2010-12-07 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US7888352B2 (en) | 2006-12-07 | 2011-02-15 | Piramed Limited | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| WO2011130654A1 (en) | 2010-04-16 | 2011-10-20 | Genentech, Inc. | Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy |
| WO2012088254A1 (en) | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms |
| US8293735B2 (en) | 2007-10-26 | 2012-10-23 | F. Hoffmann-La Roche Ag | Thienopyrimidine derivatives as P13K inhibitors |
| US8802670B2 (en) | 2006-04-26 | 2014-08-12 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| WO2014130923A2 (en) | 2013-02-25 | 2014-08-28 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
| US9487533B2 (en) | 2006-12-07 | 2016-11-08 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4054656A (en) * | 1975-09-10 | 1977-10-18 | Mead Johnson & Company | Thieno[2,3-d]pyrimidine antiallergic agents |
| US5098902A (en) * | 1991-03-18 | 1992-03-24 | Warner-Lambert Company | Method of treating neurodegenerative diseases |
| FI943798A7 (fi) * | 1992-02-19 | 1994-08-18 | Pfizer | Kasvaimenvastaisen vaikutuksen lisäämiseen tarkoitettuja heterosyklisi ä yhdisteitä |
| HRP20000209A2 (en) | 1997-10-20 | 2001-04-30 | Hoffmann La Roche | Bicyclic kinase inhibitors |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| HRP20090395T1 (hr) * | 2006-04-19 | 2009-08-31 | Boehringer Ingelheim International Gmbh | Dihidrotienpirimidini za liječenje upalnih bolesti |
| RU2500681C2 (ru) * | 2007-10-19 | 2013-12-10 | Берингер Ингельхайм Интернациональ Гмбх | Замещенные гетероциклом пиперазинодигидротиенопиримидины |
| WO2009055730A1 (en) | 2007-10-25 | 2009-04-30 | Genentech, Inc. | Process for making thienopyrimidine compounds |
| SG182247A1 (en) * | 2009-05-27 | 2012-08-30 | Hoffmann La Roche | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| GB201410816D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3259623A (en) * | 1963-06-14 | 1966-07-05 | Olin Mathieson | Process for preparing 2-(secondary amino)-halogenopyrimidines |
| DE1470356A1 (de) * | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
| US3210368A (en) * | 1964-09-29 | 1965-10-05 | Ciba Geigy Corp | Certain 2-amino-4-aryl-5-n, n-disubstituted amino-lower alkyl-thiazole compounds |
-
1972
- 1972-04-28 RO RO7200070735A patent/RO62428A/ro unknown
- 1972-05-02 HU HUTO875A patent/HU163960B/hu unknown
- 1972-05-02 ES ES402302A patent/ES402302A1/es not_active Expired
- 1972-05-03 PL PL1972155128A patent/PL82381B1/pl unknown
- 1972-05-03 BG BG020371A patent/BG20593A3/xx unknown
- 1972-05-03 GB GB2058472A patent/GB1393161A/en not_active Expired
- 1972-05-03 US US249782A patent/US3888851A/en not_active Expired - Lifetime
- 1972-05-03 DK DK219672AA patent/DK129844B/da unknown
- 1972-05-03 IL IL39341A patent/IL39341A/xx unknown
- 1972-05-03 AU AU41815/72A patent/AU4181572A/en not_active Expired
- 1972-05-03 AT AT382972A patent/AT318619B/de not_active IP Right Cessation
- 1972-05-03 DD DD162711A patent/DD97656A5/xx unknown
- 1972-05-04 NL NL7206041A patent/NL7206041A/xx unknown
- 1972-05-04 BE BE783044A patent/BE783044A/xx unknown
- 1972-05-04 FR FR7215929A patent/FR2135294B1/fr not_active Expired
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7872003B2 (en) | 2004-10-25 | 2011-01-18 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US7750002B2 (en) | 2004-10-25 | 2010-07-06 | Piramed Limited | Pharmaceutical compounds |
| US7776856B2 (en) | 2004-10-25 | 2010-08-17 | F. Hoffman-La Roche Ag | Pharmaceutical compounds |
| US8946217B2 (en) | 2004-10-25 | 2015-02-03 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US8153629B2 (en) | 2004-10-25 | 2012-04-10 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US8101607B2 (en) | 2004-10-25 | 2012-01-24 | F. Hoffman-La Roche Ag | Pharmaceutical compounds |
| US8685968B2 (en) | 2006-04-26 | 2014-04-01 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US8802670B2 (en) | 2006-04-26 | 2014-08-12 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US9943519B2 (en) | 2006-04-26 | 2018-04-17 | Genentech, Inc. | Pharmaceutical compounds |
| US8987260B2 (en) | 2006-04-26 | 2015-03-24 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US7781433B2 (en) | 2006-04-26 | 2010-08-24 | Piramed Limited | Pharmaceutical compounds |
| US7846929B2 (en) | 2006-04-26 | 2010-12-07 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US8450315B2 (en) | 2006-04-26 | 2013-05-28 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US8324206B2 (en) | 2006-04-26 | 2012-12-04 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
| EP2518074A1 (en) | 2006-12-07 | 2012-10-31 | F. Hoffmann-La Roche AG | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US8383620B2 (en) | 2006-12-07 | 2013-02-26 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US8993563B2 (en) | 2006-12-07 | 2015-03-31 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US9487533B2 (en) | 2006-12-07 | 2016-11-08 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US7888352B2 (en) | 2006-12-07 | 2011-02-15 | Piramed Limited | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| WO2009042607A1 (en) | 2007-09-24 | 2009-04-02 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
| US8293735B2 (en) | 2007-10-26 | 2012-10-23 | F. Hoffmann-La Roche Ag | Thienopyrimidine derivatives as P13K inhibitors |
| WO2010105008A2 (en) | 2009-03-12 | 2010-09-16 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies |
| WO2010138589A1 (en) | 2009-05-27 | 2010-12-02 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| WO2011130654A1 (en) | 2010-04-16 | 2011-10-20 | Genentech, Inc. | Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy |
| WO2012088254A1 (en) | 2010-12-22 | 2012-06-28 | Genentech, Inc. | Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms |
| WO2014130923A2 (en) | 2013-02-25 | 2014-08-28 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
Also Published As
| Publication number | Publication date |
|---|---|
| DK129844C (cg-RX-API-DMAC7.html) | 1975-05-12 |
| DD97656A5 (cg-RX-API-DMAC7.html) | 1973-05-12 |
| DK129844B (da) | 1974-11-25 |
| HU163960B (cg-RX-API-DMAC7.html) | 1973-11-28 |
| ES402302A1 (es) | 1975-04-01 |
| IL39341A0 (en) | 1972-07-26 |
| IL39341A (en) | 1975-08-31 |
| NL7206041A (cg-RX-API-DMAC7.html) | 1972-11-07 |
| BG20593A3 (bg) | 1975-12-05 |
| US3888851A (en) | 1975-06-10 |
| PL82381B1 (cg-RX-API-DMAC7.html) | 1975-10-31 |
| FR2135294A1 (cg-RX-API-DMAC7.html) | 1972-12-15 |
| BE783044A (fr) | 1972-11-06 |
| AT318619B (de) | 1974-11-11 |
| RO62428A (fr) | 1978-01-15 |
| FR2135294B1 (cg-RX-API-DMAC7.html) | 1975-10-17 |
| AU4181572A (en) | 1973-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |