GB1391828A - Oxindole derivatives - Google Patents
Oxindole derivativesInfo
- Publication number
- GB1391828A GB1391828A GB2874472A GB2874472A GB1391828A GB 1391828 A GB1391828 A GB 1391828A GB 2874472 A GB2874472 A GB 2874472A GB 2874472 A GB2874472 A GB 2874472A GB 1391828 A GB1391828 A GB 1391828A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- alkyl
- oxindole
- separated
- nitrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- QPBYYTKPYJRYKF-UHFFFAOYSA-N 4-(oxiran-2-ylmethoxy)-1,3-dihydroindol-2-one Chemical compound N1C(=O)CC2=C1C=CC=C2OCC1CO1 QPBYYTKPYJRYKF-UHFFFAOYSA-N 0.000 abstract 1
- FTJQLPXJRKHATE-UHFFFAOYSA-N 4-hydroxy-1,3-dihydroindol-2-one Chemical compound OC1=CC=CC2=C1CC(=O)N2 FTJQLPXJRKHATE-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- -1 aminopropoxy side chain Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000005623 oxindoles Chemical class 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH924871A CH547801A (de) | 1971-06-24 | 1971-06-24 | Verfahren zur herstellung neuer oxindole. |
| CH925171 | 1971-06-24 | ||
| CH924771A CH547800A (de) | 1971-06-24 | 1971-06-24 | Verfahren zur herstellung neuer oxindole. |
| DE19722262285 DE2262285A1 (de) | 1972-12-20 | 1972-12-20 | Verfahren zur herstellung neuer heterocyclischer verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1391828A true GB1391828A (en) | 1975-04-23 |
Family
ID=27429206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2874472A Expired GB1391828A (en) | 1971-06-24 | 1972-06-20 | Oxindole derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3825558A (enrdf_load_stackoverflow) |
| AU (1) | AU4390372A (enrdf_load_stackoverflow) |
| BE (1) | BE785282A (enrdf_load_stackoverflow) |
| DD (1) | DD99785A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2230426A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2143343B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1391828A (enrdf_load_stackoverflow) |
| NL (1) | NL7208332A (enrdf_load_stackoverflow) |
| SE (1) | SE379196B (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5786356A (en) * | 1995-09-21 | 1998-07-28 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US5840738A (en) * | 1996-09-05 | 1998-11-24 | Eli Lilly And Company | Selective β-3 adrenergic agonists |
| US6046227A (en) * | 1997-12-05 | 2000-04-04 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6140352A (en) * | 1996-09-05 | 2000-10-31 | Eli Lilly And Company | Carbazolyl-substituted ethanolamines as selective β-3 agonists |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH578526A5 (enrdf_load_stackoverflow) * | 1972-06-23 | 1976-08-13 | Sandoz Ag | |
| US4137331A (en) * | 1974-06-19 | 1979-01-30 | Sandoz Ltd. | 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones |
| DE2905877A1 (de) | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| MC1357A1 (fr) * | 1979-12-07 | 1981-08-10 | Hoffmann La Roche | Derives de 2,3-indoledione |
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| US4657929A (en) * | 1983-10-25 | 1987-04-14 | Fisons Plc | Compounds |
| DE3426419A1 (de) * | 1984-07-18 | 1986-01-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| DE3512627A1 (de) * | 1985-04-06 | 1986-10-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel |
| FR2594438B1 (fr) * | 1986-02-14 | 1990-01-26 | Labaz Sanofi Nv | Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant |
-
1972
- 1972-06-15 SE SE7207867A patent/SE379196B/xx unknown
- 1972-06-19 US US00263768A patent/US3825558A/en not_active Expired - Lifetime
- 1972-06-19 NL NL7208332A patent/NL7208332A/xx unknown
- 1972-06-20 GB GB2874472A patent/GB1391828A/en not_active Expired
- 1972-06-22 DD DD163906A patent/DD99785A5/xx unknown
- 1972-06-22 BE BE785282A patent/BE785282A/xx not_active IP Right Cessation
- 1972-06-22 DE DE2230426A patent/DE2230426A1/de not_active Ceased
- 1972-06-23 FR FR7222696A patent/FR2143343B1/fr not_active Expired
- 1972-06-26 AU AU43903/72A patent/AU4390372A/en not_active Expired
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093735A (en) * | 1995-09-21 | 2000-07-25 | Eli Lilly And Company | Selective β-3 adrenergic agonists |
| US5786356A (en) * | 1995-09-21 | 1998-07-28 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US5939443A (en) * | 1995-09-21 | 1999-08-17 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6265581B1 (en) | 1995-09-21 | 2001-07-24 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6060492A (en) * | 1995-09-21 | 2000-05-09 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6413991B1 (en) | 1996-09-05 | 2002-07-02 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6075040A (en) * | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6140352A (en) * | 1996-09-05 | 2000-10-31 | Eli Lilly And Company | Carbazolyl-substituted ethanolamines as selective β-3 agonists |
| US5840738A (en) * | 1996-09-05 | 1998-11-24 | Eli Lilly And Company | Selective β-3 adrenergic agonists |
| US6686372B2 (en) | 1996-09-05 | 2004-02-03 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US7041684B2 (en) | 1996-09-05 | 2006-05-09 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6046227A (en) * | 1997-12-05 | 2000-04-04 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| US6617347B1 (en) | 1997-12-05 | 2003-09-09 | Eli Lilly And Company | Selective β3 adrenergic agonists |
Also Published As
| Publication number | Publication date |
|---|---|
| DD99785A5 (enrdf_load_stackoverflow) | 1973-08-20 |
| FR2143343A1 (enrdf_load_stackoverflow) | 1973-02-02 |
| FR2143343B1 (enrdf_load_stackoverflow) | 1976-03-05 |
| NL7208332A (enrdf_load_stackoverflow) | 1972-12-28 |
| AU4390372A (en) | 1974-01-03 |
| BE785282A (fr) | 1972-12-22 |
| DE2230426A1 (de) | 1973-01-11 |
| SE379196B (enrdf_load_stackoverflow) | 1975-09-29 |
| US3825558A (en) | 1974-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |