GB1383647A - Process for the manufacture of benzodiazepine derivatives - Google Patents
Process for the manufacture of benzodiazepine derivativesInfo
- Publication number
- GB1383647A GB1383647A GB3210771A GB3210771A GB1383647A GB 1383647 A GB1383647 A GB 1383647A GB 3210771 A GB3210771 A GB 3210771A GB 3210771 A GB3210771 A GB 3210771A GB 1383647 A GB1383647 A GB 1383647A
- Authority
- GB
- United Kingdom
- Prior art keywords
- manufacture
- july
- benzodiazepine derivatives
- formula
- comptroller
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 abstract 1
- 239000004312 hexamethylene tetramine Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Sealing Material Composition (AREA)
- Paints Or Removers (AREA)
Priority Applications (39)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE785963D BE785963A (fr) | 1971-07-08 | Procede pour la preparation de derives de benzodiazepine | |
| BE785962D BE785962A (fr) | 1971-07-08 | Procede pour la preparation de derives de benzodiazepine | |
| GB3210771A GB1383647A (en) | 1971-07-08 | 1971-07-08 | Process for the manufacture of benzodiazepine derivatives |
| CH859572A CH569007A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-06-09 | |
| CH932972A CH570388A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-06-21 | |
| IE926/72A IE36734B1 (en) | 1971-07-08 | 1972-07-03 | A process for the manufacture of benzodiazepine derivatives |
| IE927/72A IE36885B1 (en) | 1971-07-08 | 1972-07-03 | A process for the manufacture of benzodiazepine derivatives |
| PH13685A PH10943A (en) | 1971-07-08 | 1972-07-03 | An improved process for the manufacture of benzodiazepine derivatives |
| ZA724577A ZA724577B (en) | 1971-07-08 | 1972-07-04 | Process for the manufacture of benzodiazepine derivatives |
| IL39847A IL39847A (en) | 1971-07-08 | 1972-07-06 | Process for the manufacture of 1,3-dihydro-1-methyl-5-phenyl-(or substituted phenyl)-2h-1,4-benzodiazepin 2-one derivatives |
| FR7224437A FR2144830A1 (en) | 1971-07-08 | 1972-07-06 | 1,3-dihydro-5-(2-pyridyl)-2h-1,4-benzodiazepine-2-ones prodn |
| IL39844A IL39844A (en) | 1971-07-08 | 1972-07-06 | Process for the manufacture of 1,3-dihydro-5-(2-pyridyl)-2h-1,4-benzodiazepin-2-one derivatives |
| ZA724639A ZA724639B (en) | 1971-07-08 | 1972-07-06 | Process for the manufacture of benzodiazepine derivatives |
| CA146,477A CA963903A (en) | 1971-07-08 | 1972-07-06 | Process for the manufacture of benzodiazepine derivatives |
| YU01769/72A YU176972A (en) | 1971-07-08 | 1972-07-06 | Process for obtaining benzodiazepine derivatives |
| YU01770/72A YU177072A (en) | 1971-07-08 | 1972-07-06 | Process for preparing benzodiazepine derivatives |
| NL7209490.A NL164282C (nl) | 1971-07-08 | 1972-07-07 | Werkwijze voor de bereiding van benzodiazepine- derivaten. |
| FI1932/72A FI57258C (fi) | 1971-07-08 | 1972-07-07 | Foerfarande foer framstaellning av 1,3-dihydro-5-pyridyl-2h-1,4-bensodiazepin-derivat |
| NO02453/72*[A NO130189B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-07-07 | |
| AU44361/72A AU458347B2 (en) | 1971-07-08 | 1972-07-07 | Process forthe manufacture of benzodiazepine derivatives |
| AT584472A AT327198B (de) | 1971-07-08 | 1972-07-07 | Verfahren zur herstellung von benzodiazepinderivaten |
| FR7224668A FR2144868B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-07-07 | |
| SE7209051A SE416651B (sv) | 1971-07-08 | 1972-07-07 | Sett att framstella 1,4-bensodiazepinderivat |
| JP6811472A JPS5331878B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-07-07 | |
| HUHO1497A HU168636B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-07-07 | |
| SE7209050A SE416807B (sv) | 1971-07-08 | 1972-07-07 | Sett att framstella 1,4-bensodiazepinderivat |
| NO2454/72A NO132320C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-07-07 | |
| DE19722233483 DE2233483C3 (de) | 1971-07-08 | 1972-07-07 | Verfahren zur Herstellung von 7-Brom-l,3-dihydro-5-<2-pvridyl)-2H-l,4benzodiazepin-2-on |
| HUHO1496A HU166414B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-07-08 | 1972-07-07 | |
| ES404626A ES404626A1 (es) | 1971-07-08 | 1972-07-07 | Un procedimiento para la preparacion de derivados de benzo-diacepina. |
| DE2233482A DE2233482A1 (de) | 1971-07-08 | 1972-07-07 | Verfahren zur herstellung von benzodiazepin-derivaten |
| NL7209489.A NL167426C (nl) | 1971-07-08 | 1972-07-07 | Werkwijze voor de bereiding van benzodiazepinederivaten. |
| AU44362/72A AU463475B2 (en) | 1971-07-08 | 1972-07-07 | Process forthe manufacture of benzodiazepine derivatives |
| ES404627A ES404627A1 (es) | 1971-07-08 | 1972-07-07 | Un procedimiento para la preparacion de derivados de benzo-diacepina. |
| AR242957A AR192656A1 (es) | 1971-07-08 | 1972-07-07 | Procedimiento para la preparacion de derivados de benzodiacepina |
| AR242956A AR192655A1 (es) | 1971-07-08 | 1972-07-07 | Procedimiento para la preparacion de derivados de benzodiacepina |
| DK341372A DK147482C (da) | 1971-07-08 | 1972-07-07 | Fremgangsmaade til fremstilling af benzodiazepinderivater |
| AT584672A AT334376B (de) | 1971-07-08 | 1972-07-07 | Verfahren zur herstellung von benzodiazepin-derivaten |
| KE286178A KE2861A (en) | 1971-07-08 | 1978-07-22 | A process for the manufacture of benzodiazepine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3210771A GB1383647A (en) | 1971-07-08 | 1971-07-08 | Process for the manufacture of benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1383647A true GB1383647A (en) | 1974-02-12 |
Family
ID=10333351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3210771A Expired GB1383647A (en) | 1971-07-08 | 1971-07-08 | Process for the manufacture of benzodiazepine derivatives |
Country Status (18)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH578544A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-08-21 | 1976-08-13 | Hoffmann La Roche | |
| JPS52106881A (en) * | 1976-03-05 | 1977-09-07 | Crc Ricerca Chim | Production of 1*44 benzodiazepine derivative |
| FR2364207A1 (fr) * | 1976-09-09 | 1978-04-07 | Scherico Ltd | Procede ameliore pour la preparation de 1,4-benzodiazepines |
| CN103804310A (zh) * | 2013-11-19 | 2014-05-21 | 华中药业股份有限公司 | 一种制备高纯度7-氯-5-苯基-苯并二氮杂卓-2-酮的方法 |
-
0
- BE BE785962D patent/BE785962A/xx unknown
-
1971
- 1971-07-08 GB GB3210771A patent/GB1383647A/en not_active Expired
-
1972
- 1972-06-21 CH CH932972A patent/CH570388A5/xx not_active IP Right Cessation
- 1972-07-03 PH PH13685A patent/PH10943A/en unknown
- 1972-07-03 IE IE927/72A patent/IE36885B1/xx unknown
- 1972-07-04 ZA ZA724577A patent/ZA724577B/xx unknown
- 1972-07-06 IL IL39847A patent/IL39847A/xx unknown
- 1972-07-06 CA CA146,477A patent/CA963903A/en not_active Expired
- 1972-07-06 YU YU01769/72A patent/YU176972A/xx unknown
- 1972-07-06 ZA ZA724639A patent/ZA724639B/xx unknown
- 1972-07-07 AT AT584672A patent/AT334376B/de active
- 1972-07-07 NL NL7209489.A patent/NL167426C/xx not_active IP Right Cessation
- 1972-07-07 ES ES404627A patent/ES404627A1/es not_active Expired
- 1972-07-07 AU AU44362/72A patent/AU463475B2/en not_active Expired
- 1972-07-07 AR AR242956A patent/AR192655A1/es active
- 1972-07-07 NO NO02453/72*[A patent/NO130189B/no unknown
- 1972-07-07 HU HUHO1497A patent/HU168636B/hu unknown
- 1972-07-07 FR FR7224668A patent/FR2144868B1/fr not_active Expired
- 1972-07-07 DE DE2233482A patent/DE2233482A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE2233482A1 (de) | 1973-01-25 |
| PH10943A (en) | 1977-10-05 |
| HU168636B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-06-28 |
| AR192655A1 (es) | 1973-02-28 |
| CH570388A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-12-15 |
| NL7209489A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-01-10 |
| NO130189B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-07-22 |
| NL167426B (nl) | 1981-07-16 |
| ATA584672A (de) | 1976-05-15 |
| ES404627A1 (es) | 1975-06-16 |
| AU4436272A (en) | 1974-01-10 |
| NL167426C (nl) | 1981-12-16 |
| FR2144868B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-05-14 |
| YU176972A (en) | 1979-07-10 |
| CA963903A (en) | 1975-03-04 |
| ZA724577B (en) | 1973-03-28 |
| IE36885L (en) | 1973-01-08 |
| IL39847A (en) | 1976-05-31 |
| AT334376B (de) | 1976-01-10 |
| BE785962A (fr) | 1973-01-08 |
| AU463475B2 (en) | 1975-07-31 |
| FR2144868A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-02-16 |
| IL39847A0 (en) | 1972-09-28 |
| ZA724639B (en) | 1973-03-28 |
| IE36885B1 (en) | 1977-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |