IE36734B1 - A process for the manufacture of benzodiazepine derivatives - Google Patents
A process for the manufacture of benzodiazepine derivativesInfo
- Publication number
- IE36734B1 IE36734B1 IE926/72A IE92672A IE36734B1 IE 36734 B1 IE36734 B1 IE 36734B1 IE 926/72 A IE926/72 A IE 926/72A IE 92672 A IE92672 A IE 92672A IE 36734 B1 IE36734 B1 IE 36734B1
- Authority
- IE
- Ireland
- Prior art keywords
- manufacture
- benzodiazepine derivatives
- mole
- halobenzoyl
- convulsants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Title cpds of formula (I): (where R1 = H or hal and R2 = H or 1. alkyl), are prepd. by reacting hexamethylenetetramine (II) with the appropriate 2-(2-halobenzoyl)pyridine, in an aq. hydroxylic- org. medium in the presence of a non-oxidising acid, pref. HCl (<1 mole/mole (II)). (I) are known sedatives, muscle relaxants and anti-convulsants.
[FR2144830A1]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3210771A GB1383647A (en) | 1971-07-08 | 1971-07-08 | Process for the manufacture of benzodiazepine derivatives |
US18750071A | 1971-10-07 | 1971-10-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE36734L IE36734L (en) | 1973-01-08 |
IE36734B1 true IE36734B1 (en) | 1977-02-16 |
Family
ID=26261215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE926/72A IE36734B1 (en) | 1971-07-08 | 1972-07-03 | A process for the manufacture of benzodiazepine derivatives |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS5331878B1 (en) |
AR (1) | AR192656A1 (en) |
AT (1) | AT327198B (en) |
AU (1) | AU458347B2 (en) |
BE (1) | BE785963A (en) |
CH (1) | CH569007A5 (en) |
DK (1) | DK147482C (en) |
ES (1) | ES404626A1 (en) |
FI (1) | FI57258C (en) |
FR (1) | FR2144830A1 (en) |
HU (1) | HU166414B (en) |
IE (1) | IE36734B1 (en) |
IL (1) | IL39844A (en) |
NL (1) | NL164282C (en) |
NO (1) | NO132320C (en) |
SE (2) | SE416651B (en) |
YU (1) | YU177072A (en) |
-
0
- BE BE785963D patent/BE785963A/en not_active IP Right Cessation
-
1972
- 1972-06-09 CH CH859572A patent/CH569007A5/xx not_active IP Right Cessation
- 1972-07-03 IE IE926/72A patent/IE36734B1/en unknown
- 1972-07-06 FR FR7224437A patent/FR2144830A1/en active Granted
- 1972-07-06 IL IL39844A patent/IL39844A/en unknown
- 1972-07-06 YU YU01770/72A patent/YU177072A/en unknown
- 1972-07-07 HU HUHO1496A patent/HU166414B/hu unknown
- 1972-07-07 AT AT584472A patent/AT327198B/en not_active IP Right Cessation
- 1972-07-07 FI FI1932/72A patent/FI57258C/en active
- 1972-07-07 JP JP6811472A patent/JPS5331878B1/ja active Pending
- 1972-07-07 AU AU44361/72A patent/AU458347B2/en not_active Expired
- 1972-07-07 NO NO2454/72A patent/NO132320C/no unknown
- 1972-07-07 SE SE7209051A patent/SE416651B/en unknown
- 1972-07-07 ES ES404626A patent/ES404626A1/en not_active Expired
- 1972-07-07 DK DK341372A patent/DK147482C/en active
- 1972-07-07 NL NL7209490.A patent/NL164282C/en not_active IP Right Cessation
- 1972-07-07 SE SE7209050A patent/SE416807B/en unknown
- 1972-07-07 AR AR242957A patent/AR192656A1/en active
Also Published As
Publication number | Publication date |
---|---|
AU4436172A (en) | 1974-01-10 |
HU166414B (en) | 1975-03-28 |
DK147482B (en) | 1984-08-27 |
IL39844A (en) | 1976-07-30 |
IE36734L (en) | 1973-01-08 |
NO132320C (en) | 1975-10-22 |
BE785963A (en) | 1973-01-08 |
NL7209490A (en) | 1973-01-10 |
SE416807B (en) | 1981-02-09 |
ATA584472A (en) | 1975-04-15 |
IL39844A0 (en) | 1972-09-28 |
DE2233483B2 (en) | 1977-03-24 |
AT327198B (en) | 1976-01-26 |
YU177072A (en) | 1982-02-25 |
NL164282C (en) | 1980-12-15 |
SE416651B (en) | 1981-01-26 |
AU458347B2 (en) | 1975-02-27 |
AR192656A1 (en) | 1973-02-28 |
JPS5331878B1 (en) | 1978-09-05 |
FI57258B (en) | 1980-03-31 |
CH569007A5 (en) | 1975-11-14 |
DE2233483A1 (en) | 1973-01-25 |
ES404626A1 (en) | 1975-11-16 |
FR2144830A1 (en) | 1973-02-16 |
FI57258C (en) | 1980-07-10 |
DK147482C (en) | 1985-03-25 |
FR2144830B1 (en) | 1975-11-28 |
NO132320B (en) | 1975-07-14 |
NL164282B (en) | 1980-07-15 |
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