IE36734B1 - A process for the manufacture of benzodiazepine derivatives - Google Patents

A process for the manufacture of benzodiazepine derivatives

Info

Publication number
IE36734B1
IE36734B1 IE926/72A IE92672A IE36734B1 IE 36734 B1 IE36734 B1 IE 36734B1 IE 926/72 A IE926/72 A IE 926/72A IE 92672 A IE92672 A IE 92672A IE 36734 B1 IE36734 B1 IE 36734B1
Authority
IE
Ireland
Prior art keywords
manufacture
benzodiazepine derivatives
mole
halobenzoyl
convulsants
Prior art date
Application number
IE926/72A
Other versions
IE36734L (en
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3210771A external-priority patent/GB1383647A/en
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Publication of IE36734L publication Critical patent/IE36734L/en
Publication of IE36734B1 publication Critical patent/IE36734B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds of formula (I): (where R1 = H or hal and R2 = H or 1. alkyl), are prepd. by reacting hexamethylenetetramine (II) with the appropriate 2-(2-halobenzoyl)pyridine, in an aq. hydroxylic- org. medium in the presence of a non-oxidising acid, pref. HCl (<1 mole/mole (II)). (I) are known sedatives, muscle relaxants and anti-convulsants. [FR2144830A1]
IE926/72A 1971-07-08 1972-07-03 A process for the manufacture of benzodiazepine derivatives IE36734B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3210771A GB1383647A (en) 1971-07-08 1971-07-08 Process for the manufacture of benzodiazepine derivatives
US18750071A 1971-10-07 1971-10-07

Publications (2)

Publication Number Publication Date
IE36734L IE36734L (en) 1973-01-08
IE36734B1 true IE36734B1 (en) 1977-02-16

Family

ID=26261215

Family Applications (1)

Application Number Title Priority Date Filing Date
IE926/72A IE36734B1 (en) 1971-07-08 1972-07-03 A process for the manufacture of benzodiazepine derivatives

Country Status (17)

Country Link
JP (1) JPS5331878B1 (en)
AR (1) AR192656A1 (en)
AT (1) AT327198B (en)
AU (1) AU458347B2 (en)
BE (1) BE785963A (en)
CH (1) CH569007A5 (en)
DK (1) DK147482C (en)
ES (1) ES404626A1 (en)
FI (1) FI57258C (en)
FR (1) FR2144830A1 (en)
HU (1) HU166414B (en)
IE (1) IE36734B1 (en)
IL (1) IL39844A (en)
NL (1) NL164282C (en)
NO (1) NO132320C (en)
SE (2) SE416651B (en)
YU (1) YU177072A (en)

Also Published As

Publication number Publication date
AU4436172A (en) 1974-01-10
HU166414B (en) 1975-03-28
DK147482B (en) 1984-08-27
IL39844A (en) 1976-07-30
IE36734L (en) 1973-01-08
NO132320C (en) 1975-10-22
BE785963A (en) 1973-01-08
NL7209490A (en) 1973-01-10
SE416807B (en) 1981-02-09
ATA584472A (en) 1975-04-15
IL39844A0 (en) 1972-09-28
DE2233483B2 (en) 1977-03-24
AT327198B (en) 1976-01-26
YU177072A (en) 1982-02-25
NL164282C (en) 1980-12-15
SE416651B (en) 1981-01-26
AU458347B2 (en) 1975-02-27
AR192656A1 (en) 1973-02-28
JPS5331878B1 (en) 1978-09-05
FI57258B (en) 1980-03-31
CH569007A5 (en) 1975-11-14
DE2233483A1 (en) 1973-01-25
ES404626A1 (en) 1975-11-16
FR2144830A1 (en) 1973-02-16
FI57258C (en) 1980-07-10
DK147482C (en) 1985-03-25
FR2144830B1 (en) 1975-11-28
NO132320B (en) 1975-07-14
NL164282B (en) 1980-07-15

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