IE36885B1 - A process for the manufacture of benzodiazepine derivatives - Google Patents
A process for the manufacture of benzodiazepine derivativesInfo
- Publication number
- IE36885B1 IE36885B1 IE927/72A IE92772A IE36885B1 IE 36885 B1 IE36885 B1 IE 36885B1 IE 927/72 A IE927/72 A IE 927/72A IE 92772 A IE92772 A IE 92772A IE 36885 B1 IE36885 B1 IE 36885B1
- Authority
- IE
- Ireland
- Prior art keywords
- manufacture
- july
- benzodiazepine derivatives
- formula
- gb1383647a
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 abstract 1
- 239000004312 hexamethylene tetramine Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Sealing Material Composition (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3210771A GB1383647A (en) | 1971-07-08 | 1971-07-08 | Process for the manufacture of benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36885L IE36885L (en) | 1973-01-08 |
| IE36885B1 true IE36885B1 (en) | 1977-03-16 |
Family
ID=10333351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE927/72A IE36885B1 (en) | 1971-07-08 | 1972-07-03 | A process for the manufacture of benzodiazepine derivatives |
Country Status (18)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804310A (zh) * | 2013-11-19 | 2014-05-21 | 华中药业股份有限公司 | 一种制备高纯度7-氯-5-苯基-苯并二氮杂卓-2-酮的方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH578544A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-08-21 | 1976-08-13 | Hoffmann La Roche | |
| JPS52106881A (en) * | 1976-03-05 | 1977-09-07 | Crc Ricerca Chim | Production of 1*44 benzodiazepine derivative |
| FR2364207A1 (fr) * | 1976-09-09 | 1978-04-07 | Scherico Ltd | Procede ameliore pour la preparation de 1,4-benzodiazepines |
-
0
- BE BE785962D patent/BE785962A/xx unknown
-
1971
- 1971-07-08 GB GB3210771A patent/GB1383647A/en not_active Expired
-
1972
- 1972-06-21 CH CH932972A patent/CH570388A5/xx not_active IP Right Cessation
- 1972-07-03 PH PH13685A patent/PH10943A/en unknown
- 1972-07-03 IE IE927/72A patent/IE36885B1/xx unknown
- 1972-07-04 ZA ZA724577A patent/ZA724577B/xx unknown
- 1972-07-06 ZA ZA724639A patent/ZA724639B/xx unknown
- 1972-07-06 IL IL39847A patent/IL39847A/xx unknown
- 1972-07-06 YU YU01769/72A patent/YU176972A/xx unknown
- 1972-07-06 CA CA146,477A patent/CA963903A/en not_active Expired
- 1972-07-07 NL NL7209489.A patent/NL167426C/xx not_active IP Right Cessation
- 1972-07-07 NO NO02453/72*[A patent/NO130189B/no unknown
- 1972-07-07 FR FR7224668A patent/FR2144868B1/fr not_active Expired
- 1972-07-07 AR AR242956A patent/AR192655A1/es active
- 1972-07-07 DE DE2233482A patent/DE2233482A1/de not_active Ceased
- 1972-07-07 HU HUHO1497A patent/HU168636B/hu unknown
- 1972-07-07 ES ES404627A patent/ES404627A1/es not_active Expired
- 1972-07-07 AU AU44362/72A patent/AU463475B2/en not_active Expired
- 1972-07-07 AT AT584672A patent/AT334376B/de active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103804310A (zh) * | 2013-11-19 | 2014-05-21 | 华中药业股份有限公司 | 一种制备高纯度7-氯-5-苯基-苯并二氮杂卓-2-酮的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO130189B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-07-22 |
| NL167426B (nl) | 1981-07-16 |
| IL39847A (en) | 1976-05-31 |
| CH570388A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-12-15 |
| AR192655A1 (es) | 1973-02-28 |
| IE36885L (en) | 1973-01-08 |
| AU463475B2 (en) | 1975-07-31 |
| NL7209489A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-01-10 |
| AU4436272A (en) | 1974-01-10 |
| ES404627A1 (es) | 1975-06-16 |
| YU176972A (en) | 1979-07-10 |
| FR2144868B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-05-14 |
| GB1383647A (en) | 1974-02-12 |
| NL167426C (nl) | 1981-12-16 |
| FR2144868A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-02-16 |
| ATA584672A (de) | 1976-05-15 |
| HU168636B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-06-28 |
| DE2233482A1 (de) | 1973-01-25 |
| ZA724639B (en) | 1973-03-28 |
| ZA724577B (en) | 1973-03-28 |
| PH10943A (en) | 1977-10-05 |
| IL39847A0 (en) | 1972-09-28 |
| CA963903A (en) | 1975-03-04 |
| AT334376B (de) | 1976-01-10 |
| BE785962A (fr) | 1973-01-08 |
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