GB1382276A - Purification of penicillins - Google Patents
Purification of penicillinsInfo
- Publication number
- GB1382276A GB1382276A GB474372A GB474372A GB1382276A GB 1382276 A GB1382276 A GB 1382276A GB 474372 A GB474372 A GB 474372A GB 474372 A GB474372 A GB 474372A GB 1382276 A GB1382276 A GB 1382276A
- Authority
- GB
- United Kingdom
- Prior art keywords
- crystalline
- aqueous
- penicillin
- nitrate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 7
- 150000002960 penicillins Chemical class 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 6
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 5
- 229940049954 penicillin Drugs 0.000 abstract 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 4
- 229910002651 NO3 Inorganic materials 0.000 abstract 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 4
- 229910052708 sodium Inorganic materials 0.000 abstract 4
- 239000011734 sodium Substances 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Substances CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- 150000004682 monohydrates Chemical class 0.000 abstract 3
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 3
- 229910052700 potassium Inorganic materials 0.000 abstract 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 150000004683 dihydrates Chemical class 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- SLFUXNFVAANERW-UHFFFAOYSA-N ethyl hexanoate;potassium Chemical compound [K].CCCCCC(=O)OCC SLFUXNFVAANERW-UHFFFAOYSA-N 0.000 abstract 1
- BCDGQXUMWHRQCB-UHFFFAOYSA-N glycine methyl ketone Natural products CC(=O)CN BCDGQXUMWHRQCB-UHFFFAOYSA-N 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 229940043265 methyl isobutyl ketone Drugs 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000002002 slurry Substances 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 1
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11245271A | 1971-02-03 | 1971-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1382276A true GB1382276A (en) | 1975-01-29 |
Family
ID=22343981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB474372A Expired GB1382276A (en) | 1971-02-03 | 1972-02-01 | Purification of penicillins |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3711471A (OSRAM) |
| JP (1) | JPS5231880B1 (OSRAM) |
| AU (1) | AU459026B2 (OSRAM) |
| BE (1) | BE778944A (OSRAM) |
| CA (1) | CA986505A (OSRAM) |
| DE (1) | DE2205169C3 (OSRAM) |
| FR (1) | FR2124411B1 (OSRAM) |
| GB (1) | GB1382276A (OSRAM) |
| ZA (1) | ZA72609B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933797A (en) * | 1972-02-22 | 1976-01-20 | Pfizer Inc. | 6-[α-(ω-QUANIDINOALKANOYLAMIDO)ACYLAMIDO]PENICILLANIC ACIDS |
| AR204162A1 (es) * | 1972-05-08 | 1975-11-28 | Yamanouchi Pharma Co Ltd | Proceso para la preparacion de derivados de ampicilina |
| US3891627A (en) * | 1972-05-18 | 1975-06-24 | Pfizer | 6-{8 Alpha-(amidinothioacylamido)acylamido{9 penicillanic acids |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU33875B (en) * | 1968-12-02 | 1978-06-30 | Bristol Myers Co | Process for preparing antibacterial agents |
| US3579501A (en) * | 1969-08-22 | 1971-05-18 | Bristol Myers Co | 6-(alpha-(3 - guanyl - 1 - ureido)phenyl- or thienyl-acetamido)penicillanic acids |
-
1971
- 1971-02-03 US US00112452A patent/US3711471A/en not_active Expired - Lifetime
-
1972
- 1972-01-12 CA CA132234A patent/CA986505A/en not_active Expired
- 1972-01-25 AU AU38290/72A patent/AU459026B2/en not_active Expired
- 1972-01-31 ZA ZA720609A patent/ZA72609B/xx unknown
- 1972-02-01 GB GB474372A patent/GB1382276A/en not_active Expired
- 1972-02-02 FR FR7203520A patent/FR2124411B1/fr not_active Expired
- 1972-02-03 DE DE2205169A patent/DE2205169C3/de not_active Expired
- 1972-02-03 JP JP47011889A patent/JPS5231880B1/ja active Pending
- 1972-02-03 BE BE778944A patent/BE778944A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA986505A (en) | 1976-03-30 |
| ZA72609B (en) | 1972-10-25 |
| FR2124411A1 (OSRAM) | 1972-09-22 |
| BE778944A (fr) | 1972-08-03 |
| DE2205169B2 (de) | 1980-09-04 |
| AU3829072A (en) | 1973-07-26 |
| FR2124411B1 (OSRAM) | 1975-10-10 |
| JPS5231880B1 (OSRAM) | 1977-08-17 |
| US3711471A (en) | 1973-01-16 |
| AU459026B2 (en) | 1975-03-13 |
| DE2205169A1 (de) | 1972-08-17 |
| DE2205169C3 (de) | 1981-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |