GB1380095A - Carboxamidobenzoic acids as hypolipemic agents - Google Patents
Carboxamidobenzoic acids as hypolipemic agentsInfo
- Publication number
- GB1380095A GB1380095A GB4999972A GB4999972A GB1380095A GB 1380095 A GB1380095 A GB 1380095A GB 4999972 A GB4999972 A GB 4999972A GB 4999972 A GB4999972 A GB 4999972A GB 1380095 A GB1380095 A GB 1380095A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparation
- carbomethoxy
- treating
- acid
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 239000003524 antilipemic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 abstract 2
- WXVJDWMXAVMQPO-UHFFFAOYSA-N 4-chloro-3-methoxycarbonylbenzoic acid Chemical compound COC(=O)C1=CC(C(O)=O)=CC=C1Cl WXVJDWMXAVMQPO-UHFFFAOYSA-N 0.000 abstract 2
- NTPLXRHDUXRPNE-UHFFFAOYSA-N 4-methoxyacetophenone Chemical compound COC1=CC=C(C(C)=O)C=C1 NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 abstract 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- RKTRHMNWVZRZJQ-UHFFFAOYSA-N (4-fluorophenyl)methanethiol Chemical compound FC1=CC=C(CS)C=C1 RKTRHMNWVZRZJQ-UHFFFAOYSA-N 0.000 abstract 1
- IZXWCDITFDNEBY-UHFFFAOYSA-N 1-(chloromethyl)-4-fluorobenzene Chemical compound FC1=CC=C(CCl)C=C1 IZXWCDITFDNEBY-UHFFFAOYSA-N 0.000 abstract 1
- SRXFXCKTIGELTI-UHFFFAOYSA-N 2-(4-chlorophenyl)ethanamine Chemical compound NCCC1=CC=C(Cl)C=C1 SRXFXCKTIGELTI-UHFFFAOYSA-N 0.000 abstract 1
- ZVNIXAXNTKOCQU-UHFFFAOYSA-N 3-methoxycarbonyl-4-methylbenzenecarbothioic S-acid Chemical compound C(=O)(OC)C=1C=C(C(=S)O)C=CC1C ZVNIXAXNTKOCQU-UHFFFAOYSA-N 0.000 abstract 1
- MQVAHEBEWAKTBK-UHFFFAOYSA-N 4-amino-3-ethoxycarbonylbenzoic acid Chemical compound CCOC(=O)C1=CC(C(O)=O)=CC=C1N MQVAHEBEWAKTBK-UHFFFAOYSA-N 0.000 abstract 1
- XEOVONVMDYDZRL-UHFFFAOYSA-N 4-amino-3-methoxycarbonylbenzoic acid Chemical compound COC(=O)C1=CC(C(O)=O)=CC=C1N XEOVONVMDYDZRL-UHFFFAOYSA-N 0.000 abstract 1
- JDUYMWSYTIJMJO-UHFFFAOYSA-N 4-hydroxy-3-methoxycarbonylbenzoic acid Chemical compound COC(=O)C1=CC(C(O)=O)=CC=C1O JDUYMWSYTIJMJO-UHFFFAOYSA-N 0.000 abstract 1
- JIWBFQWPLSWTBT-UHFFFAOYSA-N 4-methoxy-3-methoxycarbonylbenzoic acid Chemical compound COC(=O)C1=CC(C(O)=O)=CC=C1OC JIWBFQWPLSWTBT-UHFFFAOYSA-N 0.000 abstract 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 benzylthio Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19492271A | 1971-11-02 | 1971-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1380095A true GB1380095A (en) | 1975-01-08 |
Family
ID=22719403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4999972A Expired GB1380095A (en) | 1971-11-02 | 1972-10-30 | Carboxamidobenzoic acids as hypolipemic agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3725417A (enExample) |
| JP (1) | JPS5653536B2 (enExample) |
| BE (1) | BE790859A (enExample) |
| DE (1) | DE2253748A1 (enExample) |
| FR (1) | FR2158444B1 (enExample) |
| GB (1) | GB1380095A (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476633A (en) * | 1973-10-03 | 1977-06-16 | Unilever Ltd | Dentifrice composition |
| DE2639935A1 (de) * | 1976-09-04 | 1978-03-09 | Hoechst Ag | Benzoesaeuren und verfahren zu ihrer herstellung |
| JPS6058224B2 (ja) * | 1978-07-31 | 1985-12-19 | 旭化成株式会社 | メトクロプラミドの製造方法 |
| US6525078B1 (en) | 2002-06-25 | 2003-02-25 | Cesare Casagrande | Compound for the treatment of atherosclerotic-thrombotic pathological conditions |
| TW200520745A (en) * | 2003-09-19 | 2005-07-01 | Chugai Pharmaceutical Co Ltd | Novel 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors |
| MY144232A (en) * | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3268526A (en) * | 1962-09-12 | 1966-08-23 | Monsanto Co | Heterocyclic polyhalobenzamide derivatives |
-
0
- BE BE790859D patent/BE790859A/xx not_active IP Right Cessation
-
1971
- 1971-11-02 US US00194922A patent/US3725417A/en not_active Expired - Lifetime
-
1972
- 1972-10-30 GB GB4999972A patent/GB1380095A/en not_active Expired
- 1972-11-02 DE DE2253748A patent/DE2253748A1/de active Pending
- 1972-11-02 JP JP10955672A patent/JPS5653536B2/ja not_active Expired
- 1972-11-02 FR FR7238764A patent/FR2158444B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE790859A (fr) | 1973-04-30 |
| US3725417A (en) | 1973-04-03 |
| DE2253748A1 (de) | 1973-05-30 |
| FR2158444A1 (enExample) | 1973-06-15 |
| JPS5653536B2 (enExample) | 1981-12-19 |
| FR2158444B1 (enExample) | 1975-10-31 |
| JPS4861448A (enExample) | 1973-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |