GB1376437A - Nucleoside derivatives and the preparation thereof - Google Patents
Nucleoside derivatives and the preparation thereofInfo
- Publication number
- GB1376437A GB1376437A GB5442671A GB5442671A GB1376437A GB 1376437 A GB1376437 A GB 1376437A GB 5442671 A GB5442671 A GB 5442671A GB 5442671 A GB5442671 A GB 5442671A GB 1376437 A GB1376437 A GB 1376437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pentofuranosyl
- thio
- azauracils
- azauracil
- alkanoyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- 125000005333 aroyloxy group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 210000005170 neoplastic cell Anatomy 0.000 abstract 2
- 229940036565 thiouracil antithyroid preparations Drugs 0.000 abstract 2
- HZPZCLDCTLLJTF-UHFFFAOYSA-N 3-sulfanylidene-2h-1,2,4-triazin-5-one Chemical compound O=C1C=NNC(=S)N1 HZPZCLDCTLLJTF-UHFFFAOYSA-N 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal alkoxide Chemical class 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- ZEMGGZBWXRYJHK-UHFFFAOYSA-N thiouracil Chemical compound O=C1C=CNC(=S)N1 ZEMGGZBWXRYJHK-UHFFFAOYSA-N 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10042370A | 1970-12-21 | 1970-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1376437A true GB1376437A (en) | 1974-12-04 |
Family
ID=22279694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5442671A Expired GB1376437A (en) | 1970-12-21 | 1971-11-23 | Nucleoside derivatives and the preparation thereof |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE777053A (enExample) |
| DE (1) | DE2162616A1 (enExample) |
| FR (1) | FR2118956B1 (enExample) |
| GB (1) | GB1376437A (enExample) |
| NL (1) | NL7117347A (enExample) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3463850A (en) * | 1967-01-03 | 1969-08-26 | Merck & Co Inc | Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof |
| DE1795357A1 (de) * | 1968-09-18 | 1972-01-05 | Schering Ag | 2-Thio-pyrimidin-nucleoside |
| FR2066931A2 (en) * | 1970-10-30 | 1971-08-13 | Schering Ag | 2-thio -6-aza-uridine derivs |
-
1971
- 1971-11-23 GB GB5442671A patent/GB1376437A/en not_active Expired
- 1971-12-16 DE DE19712162616 patent/DE2162616A1/de active Pending
- 1971-12-17 NL NL7117347A patent/NL7117347A/xx unknown
- 1971-12-20 FR FR7145789A patent/FR2118956B1/fr not_active Expired
- 1971-12-21 BE BE777053A patent/BE777053A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2162616A1 (de) | 1972-07-13 |
| BE777053A (fr) | 1972-06-21 |
| FR2118956A1 (enExample) | 1972-08-04 |
| FR2118956B1 (enExample) | 1975-10-10 |
| NL7117347A (enExample) | 1972-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 49S | Specification amended (sect. 9/1949) | ||
| SPA | Amended specification published | ||
| PCNP | Patent ceased through non-payment of renewal fee |