GB550970A - Manufacture of arylacetonitrile derivatives - Google Patents

Manufacture of arylacetonitrile derivatives

Info

Publication number
GB550970A
GB550970A GB1489341A GB1489341A GB550970A GB 550970 A GB550970 A GB 550970A GB 1489341 A GB1489341 A GB 1489341A GB 1489341 A GB1489341 A GB 1489341A GB 550970 A GB550970 A GB 550970A
Authority
GB
United Kingdom
Prior art keywords
arylacetonitrile
bis
chloroethylmethylformal
phenylacetonitrile
hydroxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1489341A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Products Ltd
Original Assignee
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Products Ltd filed Critical Roche Products Ltd
Priority to GB1489341A priority Critical patent/GB550970A/en
Publication of GB550970A publication Critical patent/GB550970A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)

Abstract

550,970. Arylacetonitrile derivatives. ROCHE PRODUCTS, Ltd., BERGEL, F., HINDLEY, N. C., MORRISON, A. L., and RINDERKNECHT, H. Nov. 19, 1941, No. 14893. [Class 2 (iii)] αα-Bis-(#<SP>1</SP>-hydroxyethyl)-arylacetonitriles, in which the aryl group may carry substituents not interfering with the reaction, are prepared by condensing an arylacetonitrile having an active methylene group with slightly more than two molecular proportions of a formal of the formula X- (CH 2 ) 2 -O-CH 2 -O-(CH 2 ) n -CH 3 , where X is halogen, m is zero or an integer, in presence of an alkaline condensing agent (sodamide) capable of forming an alkali derivative of the arylacetonitrile, and subjecting the condensation product to mild hydrolysis under acid conditions. In examples #-chloroethylmethylformal is condensed with benzyl cyanide to form αα-bis-[#<SP>1</SP>-(methoxy-methyleneoxy)-ethyl]-phenylacetonitrile which is hydrolysed to αα-bis-(#<SP>1</SP>-hydroxyethyl)-phenylacetonitrile. #-Chloroethylmethylformal is made by the action of chloromethyl ether on ethylene oxide at -5‹-to-10‹C. Specification 550,963 is referred to.
GB1489341A 1941-11-19 1941-11-19 Manufacture of arylacetonitrile derivatives Expired GB550970A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1489341A GB550970A (en) 1941-11-19 1941-11-19 Manufacture of arylacetonitrile derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1489341A GB550970A (en) 1941-11-19 1941-11-19 Manufacture of arylacetonitrile derivatives

Publications (1)

Publication Number Publication Date
GB550970A true GB550970A (en) 1943-02-02

Family

ID=10049394

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1489341A Expired GB550970A (en) 1941-11-19 1941-11-19 Manufacture of arylacetonitrile derivatives

Country Status (1)

Country Link
GB (1) GB550970A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2421729A (en) * 1943-05-20 1947-06-03 Burroughs Wellcome Co Production of 3-aryl-1, 5-dibrompentane-3-carboxylic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2421729A (en) * 1943-05-20 1947-06-03 Burroughs Wellcome Co Production of 3-aryl-1, 5-dibrompentane-3-carboxylic acid

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