GB1366931A - Dihydrocodeine manufacture - Google Patents
Dihydrocodeine manufactureInfo
- Publication number
- GB1366931A GB1366931A GB508171A GB508171A GB1366931A GB 1366931 A GB1366931 A GB 1366931A GB 508171 A GB508171 A GB 508171A GB 508171 A GB508171 A GB 508171A GB 1366931 A GB1366931 A GB 1366931A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydrocodeine
- crude
- solution
- feb
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960000920 dihydrocodeine Drugs 0.000 title abstract 8
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 title 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003054 catalyst Substances 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 229960000240 hydrocodone Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 abstract 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 1
- 229910003446 platinum oxide Inorganic materials 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB508171A GB1366931A (en) | 1971-02-22 | 1971-02-22 | Dihydrocodeine manufacture |
| IL38749A IL38749A (en) | 1971-02-22 | 1972-02-14 | Dihydrocodeine manufacture |
| CA134,891A CA987317A (en) | 1971-02-22 | 1972-02-15 | Process for production of dihydrocodeine |
| DE2207516A DE2207516C2 (de) | 1971-02-22 | 1972-02-17 | Verfahren zur Herstellung von 1-Dihydrocodein mit hohem Reinheitsgrad mittels katalytischer Hydrierung von 1-Dihydrocodeinen |
| SE7202095A SE393616B (sv) | 1971-02-22 | 1972-02-21 | Forfarande for framstellning av dihydrokodein |
| YU00472/72A YU47272A (en) | 1971-02-22 | 1972-02-21 | Improved process for preparing 1-dihydrocodeine |
| JP1798972A JPS5614672B1 (enrdf_load_stackoverflow) | 1971-02-22 | 1972-02-21 | |
| HUMA2325A HU164284B (enrdf_load_stackoverflow) | 1971-02-22 | 1972-02-21 | |
| CS1102A CS167968B2 (enrdf_load_stackoverflow) | 1971-02-22 | 1972-02-21 | |
| BE779598A BE779598A (fr) | 1971-02-22 | 1972-02-21 | Procede ameliore de fabrication de 1-dihydrocodeine |
| YU427/72A YU39579B (en) | 1971-02-22 | 1972-02-21 | Process for obtaining purified 1-dihydrocodeine |
| US00228367A US3830819A (en) | 1971-02-22 | 1972-02-22 | Manufacture of i-dihydrocodeine |
| CH250672A CH561214A5 (enrdf_load_stackoverflow) | 1971-02-22 | 1972-02-22 | |
| FR7205914A FR2126278B1 (enrdf_load_stackoverflow) | 1971-02-22 | 1972-02-22 | |
| NLAANVRAGE7202337,A NL175062C (nl) | 1971-02-22 | 1972-02-22 | Werkwijze voor het katalytisch hydrogeneren van l-dihydrocodeinon tot l-dihydrocodeine. |
| PL1972153613A PL82275B1 (en) | 1971-02-22 | 1972-02-22 | Dihydrocodeine manufacture[gb1366931a] |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB508171A GB1366931A (en) | 1971-02-22 | 1971-02-22 | Dihydrocodeine manufacture |
| GB4024571 | 1971-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1366931A true GB1366931A (en) | 1974-09-18 |
Family
ID=26239609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB508171A Expired GB1366931A (en) | 1971-02-22 | 1971-02-22 | Dihydrocodeine manufacture |
Country Status (14)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853402B2 (en) | 2009-08-17 | 2014-10-07 | Johnson Matthey Public Limited Company | Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8729266B2 (en) * | 2007-07-17 | 2014-05-20 | Mallinckrodt Llc | Preparation of N-alkylated opiates by reductive amination |
| KR102691151B1 (ko) * | 2021-12-09 | 2024-08-05 | 박을준 | 카테터, 카테터 조작 방법 및 카테터 시스템 |
-
1971
- 1971-02-22 GB GB508171A patent/GB1366931A/en not_active Expired
-
1972
- 1972-02-14 IL IL38749A patent/IL38749A/xx unknown
- 1972-02-15 CA CA134,891A patent/CA987317A/en not_active Expired
- 1972-02-17 DE DE2207516A patent/DE2207516C2/de not_active Expired
- 1972-02-21 HU HUMA2325A patent/HU164284B/hu unknown
- 1972-02-21 JP JP1798972A patent/JPS5614672B1/ja active Pending
- 1972-02-21 CS CS1102A patent/CS167968B2/cs unknown
- 1972-02-21 YU YU427/72A patent/YU39579B/xx unknown
- 1972-02-21 YU YU00472/72A patent/YU47272A/xx unknown
- 1972-02-21 SE SE7202095A patent/SE393616B/xx unknown
- 1972-02-21 BE BE779598A patent/BE779598A/xx not_active IP Right Cessation
- 1972-02-22 NL NLAANVRAGE7202337,A patent/NL175062C/xx not_active IP Right Cessation
- 1972-02-22 CH CH250672A patent/CH561214A5/xx not_active IP Right Cessation
- 1972-02-22 FR FR7205914A patent/FR2126278B1/fr not_active Expired
- 1972-02-22 PL PL1972153613A patent/PL82275B1/pl unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853402B2 (en) | 2009-08-17 | 2014-10-07 | Johnson Matthey Public Limited Company | Process for reducing the 6-keto group of a morphinan alkaloid to the 6-hydroxy group by hydrogenation |
Also Published As
| Publication number | Publication date |
|---|---|
| CA987317A (en) | 1976-04-13 |
| YU39579B (en) | 1985-03-20 |
| NL7202337A (enrdf_load_stackoverflow) | 1972-08-24 |
| BE779598A (fr) | 1972-08-21 |
| IL38749A (en) | 1974-11-29 |
| CS167968B2 (enrdf_load_stackoverflow) | 1976-05-28 |
| FR2126278A1 (enrdf_load_stackoverflow) | 1972-10-06 |
| CH561214A5 (enrdf_load_stackoverflow) | 1975-04-30 |
| IL38749A0 (en) | 1972-04-27 |
| SE393616B (sv) | 1977-05-16 |
| HU164284B (enrdf_load_stackoverflow) | 1974-01-28 |
| YU47272A (en) | 1982-02-28 |
| NL175062B (nl) | 1984-04-16 |
| DE2207516C2 (de) | 1985-08-22 |
| PL82275B1 (en) | 1975-10-31 |
| JPS5614672B1 (enrdf_load_stackoverflow) | 1981-04-06 |
| NL175062C (nl) | 1984-09-17 |
| DE2207516A1 (de) | 1973-08-02 |
| FR2126278B1 (enrdf_load_stackoverflow) | 1975-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |