GB1366233A - 6-substituted-3-/2-/5-nitro-2-furyl/-vinyl/-zeta-triazolo-/4,3-b/- pyridazines methods for their preparation and compositions containi ng them - Google Patents
6-substituted-3-/2-/5-nitro-2-furyl/-vinyl/-zeta-triazolo-/4,3-b/- pyridazines methods for their preparation and compositions containi ng themInfo
- Publication number
- GB1366233A GB1366233A GB2109573A GB2109573A GB1366233A GB 1366233 A GB1366233 A GB 1366233A GB 2109573 A GB2109573 A GB 2109573A GB 2109573 A GB2109573 A GB 2109573A GB 1366233 A GB1366233 A GB 1366233A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- nitro
- triazolo
- furyl
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920002554 vinyl polymer Polymers 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- -1 5 - Nitro - 2 - furyl Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- YKWLQCJSMKNMOW-UHFFFAOYSA-N 3-[2-(5-nitrofuran-2-yl)ethenyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-amine Chemical compound NC=1C=CC=2N(N1)C(=NN2)C=CC=2OC(=CC2)[N+](=O)[O-] YKWLQCJSMKNMOW-UHFFFAOYSA-N 0.000 abstract 1
- SXINBFXPADXIEY-UHFFFAOYSA-N 5-Nitrofurfural Chemical compound [O-][N+](=O)C1=CC=C(C=O)O1 SXINBFXPADXIEY-UHFFFAOYSA-N 0.000 abstract 1
- OLOVEHVSYLDXHE-UHFFFAOYSA-N 6-(ethoxymethylidene)-3-[2-(5-nitrofuran-2-yl)ethenyl]-5H-[1,2,4]triazolo[4,3-b]pyridazin-7-amine Chemical compound [N+](=O)([O-])C1=CC=C(O1)C=CC1=NN=C2N1NC(C(=C2)N)=COCC OLOVEHVSYLDXHE-UHFFFAOYSA-N 0.000 abstract 1
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722222834 DE2222834A1 (de) | 1972-05-10 | 1972-05-10 | Nitrofuryl-amidin-derivate und verfahren zur herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1366233A true GB1366233A (en) | 1974-09-11 |
Family
ID=5844561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2109573A Expired GB1366233A (en) | 1972-05-10 | 1973-05-03 | 6-substituted-3-/2-/5-nitro-2-furyl/-vinyl/-zeta-triazolo-/4,3-b/- pyridazines methods for their preparation and compositions containi ng them |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4954395A (enExample) |
| AT (1) | AT322541B (enExample) |
| AU (1) | AU5556173A (enExample) |
| DE (1) | DE2222834A1 (enExample) |
| FR (1) | FR2183927B2 (enExample) |
| GB (1) | GB1366233A (enExample) |
| HU (1) | HU165885B (enExample) |
| NL (1) | NL7306331A (enExample) |
| ZA (1) | ZA733030B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1966214B9 (en) | 2005-12-21 | 2017-09-13 | Janssen Pharmaceutica N.V. | Triazolopyridazines as tyrosine kinase modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1318013A (en) * | 1970-06-19 | 1973-05-23 | Boehringer Mannheim Gmbh | Nitrofuran and nitrothiophene derivatives |
| DE2153902A1 (de) * | 1971-10-29 | 1973-05-03 | Boehringer Mannheim Gmbh | Antimikrobiell wirksame nitrofuranderivate und verfahren zur herstellung derselben |
| DE2030581A1 (de) * | 1970-06-20 | 1971-12-30 | Boehringer Mannheim GmbH, 6800 Mannheim-Waldhof | Nitrofuryl-amidin-Derivate und Verfahren zur Herstellung derselben |
-
1972
- 1972-05-10 DE DE19722222834 patent/DE2222834A1/de active Pending
-
1973
- 1973-05-03 GB GB2109573A patent/GB1366233A/en not_active Expired
- 1973-05-04 ZA ZA733030A patent/ZA733030B/xx unknown
- 1973-05-07 NL NL7306331A patent/NL7306331A/xx unknown
- 1973-05-07 HU HUBO1432A patent/HU165885B/hu unknown
- 1973-05-08 FR FR7316506A patent/FR2183927B2/fr not_active Expired
- 1973-05-09 AT AT408173A patent/AT322541B/de not_active IP Right Cessation
- 1973-05-09 JP JP48051524A patent/JPS4954395A/ja active Pending
- 1973-05-10 AU AU55561/73A patent/AU5556173A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2183927A2 (enExample) | 1973-12-21 |
| NL7306331A (enExample) | 1973-11-13 |
| ZA733030B (en) | 1974-04-24 |
| HU165885B (enExample) | 1974-12-28 |
| AU5556173A (en) | 1974-11-14 |
| FR2183927B2 (enExample) | 1976-12-03 |
| AT322541B (de) | 1975-05-26 |
| JPS4954395A (enExample) | 1974-05-27 |
| DE2222834A1 (de) | 1973-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |