GB1361068A - Process for preparing injectable fluorocarbon emulsion capable of carrying oxygen - Google Patents
Process for preparing injectable fluorocarbon emulsion capable of carrying oxygenInfo
- Publication number
- GB1361068A GB1361068A GB4153271A GB4153271A GB1361068A GB 1361068 A GB1361068 A GB 1361068A GB 4153271 A GB4153271 A GB 4153271A GB 4153271 A GB4153271 A GB 4153271A GB 1361068 A GB1361068 A GB 1361068A
- Authority
- GB
- United Kingdom
- Prior art keywords
- emulsion
- oxygen
- sodium
- sept
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000839 emulsion Substances 0.000 title abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000000787 lecithin Substances 0.000 abstract 2
- 229940067606 lecithin Drugs 0.000 abstract 2
- 235000010445 lecithin Nutrition 0.000 abstract 2
- 239000012266 salt solution Substances 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- LWRNQOBXRHWPGE-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,4a,5,5,6,6,7,7,8,8a-heptadecafluoro-8-(trifluoromethyl)naphthalene Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)C2(F)C(C(F)(F)F)(F)C(F)(F)C(F)(F)C(F)(F)C21F LWRNQOBXRHWPGE-UHFFFAOYSA-N 0.000 abstract 1
- HRJMHJWBJZQRKB-UHFFFAOYSA-N 1,2,2,2-tetrafluoro-1-[1,1,2,3,3,3-hexafluoro-2-[1,1,2,3,3,3-hexafluoro-2-[1,1,2,3,3,3-hexafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)propoxy]propoxy]propoxy]ethanol Chemical compound OC(C(F)(F)F)(OC(C(OC(C(OC(C(OC(C(C(F)(F)F)(F)F)(F)F)(C(F)(F)F)F)(F)F)(C(F)(F)F)F)(F)F)(C(F)(F)F)F)(F)F)F HRJMHJWBJZQRKB-UHFFFAOYSA-N 0.000 abstract 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 abstract 1
- CJFUEPJVIFJOOU-UHFFFAOYSA-N 2-perfluorobutyltetrahydrofuran Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C1CCCO1 CJFUEPJVIFJOOU-UHFFFAOYSA-N 0.000 abstract 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003633 blood substitute Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 210000002969 egg yolk Anatomy 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 150000002222 fluorine compounds Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 235000011147 magnesium chloride Nutrition 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229950011087 perflunafene Drugs 0.000 abstract 1
- UWEYRJFJVCLAGH-IJWZVTFUSA-N perfluorodecalin Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)[C@@]2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[C@@]21F UWEYRJFJVCLAGH-IJWZVTFUSA-N 0.000 abstract 1
- YVBBRRALBYAZBM-UHFFFAOYSA-N perfluorooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YVBBRRALBYAZBM-UHFFFAOYSA-N 0.000 abstract 1
- RVZRBWKZFJCCIB-UHFFFAOYSA-N perfluorotributylamine Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)N(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RVZRBWKZFJCCIB-UHFFFAOYSA-N 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 abstract 1
- 239000000176 sodium gluconate Substances 0.000 abstract 1
- 235000012207 sodium gluconate Nutrition 0.000 abstract 1
- 229940005574 sodium gluconate Drugs 0.000 abstract 1
- 239000001540 sodium lactate Substances 0.000 abstract 1
- 235000011088 sodium lactate Nutrition 0.000 abstract 1
- 229940005581 sodium lactate Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/14—Derivatives of phosphoric acid
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7802370A JPS4829122B1 (enrdf_load_stackoverflow) | 1970-09-05 | 1970-09-05 | |
| JP5700371A JPS496101B1 (enrdf_load_stackoverflow) | 1971-07-29 | 1971-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1361068A true GB1361068A (en) | 1974-07-24 |
Family
ID=26398012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4153271A Expired GB1361068A (en) | 1970-09-05 | 1971-09-06 | Process for preparing injectable fluorocarbon emulsion capable of carrying oxygen |
Country Status (5)
| Country | Link |
|---|---|
| CA (1) | CA947653A (enrdf_load_stackoverflow) |
| CH (1) | CH604490A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2144094C3 (enrdf_load_stackoverflow) |
| FR (1) | FR2105287B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1361068A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2124104A (en) * | 1982-07-27 | 1984-02-15 | Univ Pennsylvania | Perfluorochemical emulsion artificial blood |
| EP0307087B1 (en) * | 1987-08-05 | 1994-06-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions for in vivo use |
| EP1684716A4 (en) * | 2003-11-05 | 2009-04-22 | Univ Australian | DISPERSIONS AND MANUFACTURING METHOD THEREFOR |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3911138B1 (en) * | 1973-02-26 | 1996-10-29 | Childrens Hosp Medical Center | Artificial blood and method for supporting oxygen transport in animals |
| US3993581A (en) * | 1973-10-05 | 1976-11-23 | The Green Cross Corporation | Process for preparing stable oxygen transferable emulsion |
| JPS5331209B2 (enrdf_load_stackoverflow) * | 1973-10-05 | 1978-09-01 | ||
| IT1050731B (it) * | 1974-12-09 | 1981-03-20 | Childrens Hosp Medical Center | Composti perfluoropoliciclici per l impiego come sangue sintetico e ambiente di ferfusione |
| DK155867C (da) * | 1974-12-09 | 1989-10-09 | Sun Ventures Inc | Emulsionspraeparat af perfluorerede forbindelser til anvendelse som syntetisk blod |
| JPS5835485B2 (ja) * | 1976-02-03 | 1983-08-03 | 株式会社ミドリ十字 | 酸素運搬輸液 |
| FR2515198A1 (fr) * | 1981-10-22 | 1983-04-29 | Centre Nat Rech Scient | Microemulsions aqueuses de fluorocarbures indefiniment stables a une temperature donnee, procede d'obtention et application a titre de transporteurs d'oxygene |
| US4569784A (en) * | 1980-11-17 | 1986-02-11 | Adamantech, Inc. | Preparation of a gel having gas transporting capability |
| US4397870A (en) * | 1982-07-27 | 1983-08-09 | The University Of Pennsylvania | Process for prolonging retention of emulsion particles in the bloodstream |
| JPS5946218A (ja) * | 1982-09-09 | 1984-03-15 | Green Cross Corp:The | フルオロカ−ボン乳化製剤 |
| DE102021210821A1 (de) | 2021-09-28 | 2023-03-30 | Siemens Aktiengesellschaft | Schutzschaltgerät |
-
1971
- 1971-09-01 CH CH1281971A patent/CH604490A5/xx not_active IP Right Cessation
- 1971-09-02 DE DE2144094A patent/DE2144094C3/de not_active Expired
- 1971-09-03 FR FR7131983A patent/FR2105287B1/fr not_active Expired
- 1971-09-03 CA CA122,069A patent/CA947653A/en not_active Expired
- 1971-09-06 GB GB4153271A patent/GB1361068A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2124104A (en) * | 1982-07-27 | 1984-02-15 | Univ Pennsylvania | Perfluorochemical emulsion artificial blood |
| EP0307087B1 (en) * | 1987-08-05 | 1994-06-08 | Alliance Pharmaceutical Corp. | Fluorocarbon emulsions for in vivo use |
| EP1684716A4 (en) * | 2003-11-05 | 2009-04-22 | Univ Australian | DISPERSIONS AND MANUFACTURING METHOD THEREFOR |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2105287A1 (enrdf_load_stackoverflow) | 1972-04-28 |
| CA947653A (en) | 1974-05-21 |
| DE2144094A1 (de) | 1972-03-09 |
| DE2144094B2 (de) | 1980-02-14 |
| FR2105287B1 (enrdf_load_stackoverflow) | 1975-04-18 |
| CH604490A5 (enrdf_load_stackoverflow) | 1978-09-15 |
| DE2144094C3 (de) | 1980-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |