GB1355866A - Dibenzoxazepine derivatives - Google Patents
Dibenzoxazepine derivativesInfo
- Publication number
- GB1355866A GB1355866A GB3623571A GB3623571A GB1355866A GB 1355866 A GB1355866 A GB 1355866A GB 3623571 A GB3623571 A GB 3623571A GB 3623571 A GB3623571 A GB 3623571A GB 1355866 A GB1355866 A GB 1355866A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- compound
- give
- oxazepine
- trifluoromethylsulphonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RVSGRNKUJJUAPV-UHFFFAOYSA-N benzo[d][1,2]benzoxazepine Chemical class O1N=CC2=CC=CC=C2C2=CC=CC=C12 RVSGRNKUJJUAPV-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- -1 p-nitrobenzylthio Chemical group 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- LJXSBMQNFHKTLH-UHFFFAOYSA-N 6-chloro-8-(trifluoromethylsulfonyl)benzo[b][1,4]benzoxazepine Chemical compound FC(S(=O)(=O)C=1C=CC2=C(C(=NC3=C(O2)C=CC=C3)Cl)C1)(F)F LJXSBMQNFHKTLH-UHFFFAOYSA-N 0.000 abstract 1
- XCTGZPMWOXGETL-UHFFFAOYSA-N 8-(trifluoromethylsulfanyl)-5H-benzo[b][1,4]benzoxazepin-6-one Chemical compound FC(SC=1C=CC2=C(C(NC3=C(O2)C=CC=C3)=O)C1)(F)F XCTGZPMWOXGETL-UHFFFAOYSA-N 0.000 abstract 1
- ANHYNTLOZLBBPR-UHFFFAOYSA-N 8-(trifluoromethylsulfonyl)-5H-benzo[b][1,4]benzoxazepin-6-one Chemical compound FC(S(=O)(=O)C=1C=CC2=C(C(NC3=C(O2)C=CC=C3)=O)C1)(F)F ANHYNTLOZLBBPR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Insulated Conductors (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1192270A CH549593A (de) | 1970-08-06 | 1970-08-06 | Verfahren zur herstellung neuer dibenzoxazepine. |
| CH791571 | 1971-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1355866A true GB1355866A (en) | 1974-06-05 |
Family
ID=25702448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3623571A Expired GB1355866A (en) | 1970-08-06 | 1971-08-02 | Dibenzoxazepine derivatives |
Country Status (13)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491715B2 (en) | 2003-12-22 | 2009-02-17 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006034414A2 (en) | 2004-09-21 | 2006-03-30 | Hypnion, Inc. | Loxapine analogs and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1802728A1 (de) * | 1967-02-27 | 1969-06-26 | American Cyanamid Co | Neue 11-Piperazinyl-dibenz [b,f][1,4] oxazepine und analoge -thiazepine |
| BE754406A (fr) * | 1969-08-06 | 1971-02-04 | Wander Ag Dr A | Nouveaux derives de la dibenzo-oxazepine leur preparation et medicaments contenant ces derives |
-
1971
- 1971-07-29 NL NL7110453A patent/NL7110453A/xx unknown
- 1971-08-02 GB GB3623571A patent/GB1355866A/en not_active Expired
- 1971-08-03 FR FR7128447A patent/FR2102073B1/fr not_active Expired
- 1971-08-04 IL IL37437A patent/IL37437A/xx unknown
- 1971-08-04 DK DK381771AA patent/DK128355B/da unknown
- 1971-08-04 DE DE19712139016 patent/DE2139016A1/de active Pending
- 1971-08-04 ES ES393891A patent/ES393891A1/es not_active Expired
- 1971-08-04 BE BE770956A patent/BE770956A/xx unknown
- 1971-08-04 NO NO2929/71A patent/NO132097C/no unknown
- 1971-08-05 AU AU32060/71A patent/AU467072B2/en not_active Expired
- 1971-08-05 SE SE7110035A patent/SE379046B/xx unknown
- 1971-08-05 CA CA119,861A patent/CA956942A/en not_active Expired
- 1971-08-05 AT AT928373*1A patent/AT325624B/de not_active IP Right Cessation
-
1973
- 1973-06-07 AU AU56683/73A patent/AU5668373A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491715B2 (en) | 2003-12-22 | 2009-02-17 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7517871B2 (en) | 2003-12-22 | 2009-04-14 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7550454B2 (en) | 2003-12-22 | 2009-06-23 | Acadia Pharmaceuticals, Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| US7622461B2 (en) | 2003-12-22 | 2009-11-24 | Acadia Pharmaceuticals Inc. | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| ES393891A1 (es) | 1974-07-01 |
| NL7110453A (enrdf_load_stackoverflow) | 1972-02-08 |
| IL37437A0 (en) | 1971-11-29 |
| AU3206071A (en) | 1973-03-08 |
| BE770956A (fr) | 1972-02-04 |
| IL37437A (en) | 1974-05-16 |
| FR2102073B1 (enrdf_load_stackoverflow) | 1974-11-15 |
| SE379046B (enrdf_load_stackoverflow) | 1975-09-22 |
| NO132097C (enrdf_load_stackoverflow) | 1975-09-17 |
| AT325624B (de) | 1975-10-27 |
| AU5668373A (en) | 1974-12-12 |
| NO132097B (enrdf_load_stackoverflow) | 1975-06-09 |
| DK128355B (da) | 1974-04-16 |
| DE2139016A1 (de) | 1972-02-10 |
| AU467072B2 (en) | 1975-11-20 |
| CA956942A (en) | 1974-10-29 |
| FR2102073A1 (enrdf_load_stackoverflow) | 1972-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |