GB1355629A - Acyl derivatives - Google Patents
Acyl derivativesInfo
- Publication number
- GB1355629A GB1355629A GB20273A GB20273A GB1355629A GB 1355629 A GB1355629 A GB 1355629A GB 20273 A GB20273 A GB 20273A GB 20273 A GB20273 A GB 20273A GB 1355629 A GB1355629 A GB 1355629A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- formula
- group
- jan
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1355629 Hydroxyalkylpenicillins and cephalosporins F HOFFMANN-LA ROCHE & CO AG 2 Jan 1973 [3 Jan 1972] 202/73 Headings C2C and C2A Novel D-compounds having the general Formula I wherein R represents an n-butyl or isobutyl group and A represents a group of Formula (a) or (b) and its salts and their hydrates may be prepared by reacting an amine of general Formula II wherein A<SP>1</SP> represents a group of Formula (a<SP>1</SP>) or (b<SP>1</SP>) in which X represents a protected carboxy group, with a D-acid of Formula III where R is as defined above, or with a functional derivative thereof, cleaning off the protecting group and, if desired, converting the product into a salt. The compounds of the invention are thus D - 1 - hydroxy-3 - methylbutylpenicillin, D - 1- hydroxypentylpenicillin, D-1-hydroxy-3-methylbutylcephalosporin and D-1-hydroxypentylcephalosporin. D-α-hydroxyisocaproic acid succinimide and D-α-hydroxycaproic acid succinimide are prepared by reaction of D-α-hydroxyisocaproic acid and D-α-hydroxycaproic acid respectively with N-hydroxysuccinimide and dicyclohexylcarbodiirnide. 6-Aminopenicillanic acid and 7-aminocephalosporanic acid are reacted with triethylamine in chloroform or methylene chloride to obtain the corresponding amine salts. Pharmaceutical compositions having antibiotic, especially bactericidal, activity for parenteral, peroral or subcutaneous administration comprise a compound of Formula I together with a compatible pharmaceutical carrier optionally together with other known additives, such as preserving, stabilizing, wetting or emulsifying agents and/or with other known therapeutically valuable substances.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH572A CH565182A5 (en) | 1972-01-03 | 1972-01-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1355629A true GB1355629A (en) | 1974-06-05 |
Family
ID=4177249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB20273A Expired GB1355629A (en) | 1972-01-03 | 1973-01-02 | Acyl derivatives |
Country Status (16)
Country | Link |
---|---|
AR (1) | AR205150A1 (en) |
AT (1) | AT320153B (en) |
BE (1) | BE793595A (en) |
CA (1) | CA1001155A (en) |
CH (1) | CH565182A5 (en) |
DE (1) | DE2262472A1 (en) |
DK (1) | DK140553B (en) |
FR (1) | FR2181649B1 (en) |
GB (1) | GB1355629A (en) |
HU (1) | HU170008B (en) |
IE (1) | IE37053B1 (en) |
IL (1) | IL40978A (en) |
NL (1) | NL7217543A (en) |
PH (1) | PH11075A (en) |
SE (1) | SE412065B (en) |
ZA (1) | ZA728418B (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB940712A (en) * | 1961-06-23 | 1963-10-30 | Beecham Res Lab | Improvements in or relating to penicillins |
FR1393245A (en) * | 1962-05-21 | 1965-03-26 | Beecham Group Ltd | Process for the preparation of penicillins |
FR1393244A (en) * | 1962-05-21 | 1965-03-26 | Beecham Group Ltd | Process for the preparation of penicillins |
SE311519B (en) * | 1962-12-14 | 1969-06-16 | Astra Ab |
-
0
- BE BE793595D patent/BE793595A/en unknown
-
1972
- 1972-01-03 CH CH572A patent/CH565182A5/xx not_active IP Right Cessation
- 1972-11-27 ZA ZA728418A patent/ZA728418B/en unknown
- 1972-12-01 IL IL40978A patent/IL40978A/en unknown
- 1972-12-01 DK DK603572AA patent/DK140553B/en unknown
- 1972-12-20 DE DE2262472A patent/DE2262472A1/en not_active Withdrawn
- 1972-12-22 PH PH14198A patent/PH11075A/en unknown
- 1972-12-22 NL NL7217543A patent/NL7217543A/xx not_active Application Discontinuation
-
1973
- 1973-01-01 AR AR245959A patent/AR205150A1/en active
- 1973-01-02 AT AT1373A patent/AT320153B/en not_active IP Right Cessation
- 1973-01-02 CA CA160,421A patent/CA1001155A/en not_active Expired
- 1973-01-02 SE SE7300033A patent/SE412065B/en unknown
- 1973-01-02 GB GB20273A patent/GB1355629A/en not_active Expired
- 1973-01-02 IE IE2/73A patent/IE37053B1/en unknown
- 1973-01-03 HU HU73HO1538A patent/HU170008B/en unknown
- 1973-01-03 FR FR7300110A patent/FR2181649B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH565182A5 (en) | 1975-08-15 |
PH11075A (en) | 1977-10-25 |
DE2262472A1 (en) | 1973-07-19 |
CA1001155A (en) | 1976-12-07 |
DK140553B (en) | 1979-10-01 |
SE412065B (en) | 1980-02-18 |
AT320153B (en) | 1975-01-27 |
ZA728418B (en) | 1973-08-29 |
NL7217543A (en) | 1973-07-05 |
AR205150A1 (en) | 1976-04-12 |
BE793595A (en) | 1973-07-02 |
IE37053B1 (en) | 1977-04-27 |
FR2181649B1 (en) | 1976-03-05 |
AU4949272A (en) | 1974-05-30 |
FR2181649A1 (en) | 1973-12-07 |
HU170008B (en) | 1977-03-28 |
IL40978A0 (en) | 1973-02-28 |
IL40978A (en) | 1975-10-15 |
DK140553C (en) | 1980-02-18 |
IE37053L (en) | 1973-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |