NL172659C - A process for the preparation of an antibiotically active pharmaceutical composition and method for preparing a 6-ÿalfa- (3-acylureido) acetylaminoÿ penicillanzuurderivaat. - Google Patents

A process for the preparation of an antibiotically active pharmaceutical composition and method for preparing a 6-ÿalfa- (3-acylureido) acetylaminoÿ penicillanzuurderivaat.

Info

Publication number
NL172659C
NL172659C NL7107176A NL7107176A NL172659C NL 172659 C NL172659 C NL 172659C NL 7107176 A NL7107176 A NL 7107176A NL 7107176 A NL7107176 A NL 7107176A NL 172659 C NL172659 C NL 172659C
Authority
NL
Grant status
Grant
Patent type
Prior art keywords
group
lower
lower alkyl
formulμ
carbon atoms
Prior art date
Application number
NL7107176A
Other languages
Dutch (nl)
Other versions
NL7107176A (en )
NL172659B (en )
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/58Y being a hetero atom
    • C07C275/60Y being an oxygen atom, e.g. allophanic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/32One oxygen atom
    • C07D233/38One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Abstract

1301962 Ureido penicillins BAYER AG 25 May 1971 [25 May 1970 1 Feb 1971 3 Feb 1971] 16881/71 Heading C2A The invention comprises penicillins of the general Formula (I) in which general formula A is a group having one of the general formulµ (2), (3) or (4) in which formulµ X is a hydrogen atom or an alkyl, alkenyl, cycloalkyl or cycloalkenyl group with up to ten carbon atoms, or a vinyl, arylvinyl, mono-, di- or tri-haloalkyl, alkyamino, dialkylamino, monoarylamino, arylalkylamino or aryloxy group or an alkoxy or aryloxy group, or an alkoxy or aryloxy group with up to 8 carbon atoms, or a cycloalkoxy group with up to 7 carbon atoms, or a group having one of the general formulµ (lower alkyl)-O-V-, (lower alkyl)-S-V-, N#C-V-,(lower alkyl)-O-CO-V- or in which formulµ V is a bivalent organic radical with 1 to 3 carbon atoms, lower alkyl groups have up to six carbon atoms; n is 0, 1 or 2 and R 1 , R 2 and R 3 may be the same or different and are each hydrogen, chlorine, bromine, iodine or fluorine, nitro, nitrile, di(lower alkyl)amino, di(lower alkyl)ammo-carbonyl, lower alkanoylamino, lower alkoxy carbonyl, lower alkanoyloxy, lower alkyl, lower alkoxy, sulphamyl or trifluoromethyl; Y is an alkyl, alkenyl, cycloalkyl or cycloalkenyl group with up to 10 carbon atoms, or a vinyl, propenyl, mono-, di- or tri-halo (lower alkyl) aryl or heterocyclic group, or an aralkyl group with up to 8-carbon atoms; #Z- is a divalent group having one of the formulµ in which formulµ n is 3, 4 or 5 and the arrow # means that the two free valencies of the group Z are not arbitrarily joined to the N and C atoms of the group (3) but are oriented as indicated by the arrow. Q is a divalent group, B is a group having one of the general formulµ in which formulµ R 4 , R 5 and R 6 may be the same or different and are each hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylthionyl, lower alkylsulphonyl, nitro, di(lower alkyl) amino, lower alkanoylamino, hydroxy, or lower alkanoyloxy and in which the chirality centre C*can have either of the two possible R and S stereoisomeric configurations or can be a mixture of these two diastereosiomers. The invention also comprises salts of the above penicillins. A process for the production of penicillins of Formula (I) comprises reacting 6-amino-penicillanic acid or a compound of the general formula (46) or (47) in which R 7 , R 8 and R 9 are the same or different alkyl groups having up to 6 carbon atoms, at a temperature of -30‹ C. to +50‹ C. with a carboxylic acid of general formula If compounds of formula (46) or (47) are used, the reaction is carried out in an anhydrous solvent which is free of hydroxyl groups, with or without a base, and if 6-aminopenicillanic acid is used, the reaction is carried out in a solvent in the presence of a base. Various modifications of the process are described. Antibiotically active pharmaceutical compositions, which contain as active ingredient at least one penicillin of Formula (I) or a pharmaceutically acceptable salt thereof, have been prepared. Such compositions also contain a pharmaceutically acceptable carrier which may be solid or liquid. These compositions may be adapted for parenteral or oral administration and may be prepared in dosage unit form.
NL7107176A 1970-05-25 1971-05-25 A process for the preparation of an antibiotically active pharmaceutical composition and method for preparing a 6-ÿalfa- (3-acylureido) acetylaminoÿ penicillanzuurderivaat. NL172659C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19702025415 DE2025415C3 (en) 1970-05-25 1970-05-25
DE19712104579 DE2104579C3 (en) 1971-02-01 1971-02-01

Publications (3)

Publication Number Publication Date
NL7107176A true NL7107176A (en) 1971-11-29
NL172659B true NL172659B (en) 1983-05-02
NL172659C true NL172659C (en) 1983-10-03

Family

ID=25759180

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7107176A NL172659C (en) 1970-05-25 1971-05-25 A process for the preparation of an antibiotically active pharmaceutical composition and method for preparing a 6-ÿalfa- (3-acylureido) acetylaminoÿ penicillanzuurderivaat.

Country Status (10)

Country Link
JP (1) JPS55390B1 (en)
BE (1) BE767648A (en)
CA (1) CA932722A (en)
DK (1) DK134438C (en)
ES (4) ES391533A1 (en)
FI (1) FI54485C (en)
FR (1) FR2100682B1 (en)
GB (1) GB1301962A (en)
LU (1) LU63204A1 (en)
NL (1) NL172659C (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2260118C2 (en) * 1972-12-08 1982-06-03 Bayer Ag, 5090 Leverkusen, De
DE2354219A1 (en) * 1973-10-30 1975-05-07 Bayer Ag Beta-lactam antibiotics, a process for their production and their use as medicines
GB1486349A (en) * 1974-11-28 1977-09-21 Bayer Ag Beta-lactam antibiotics process for their preparation and their use as medicaments
GB1584400A (en) * 1976-12-24 1981-02-11 Bayer Ag (2-oxo-imidazoliden-1-yl(carbonylamino)-acetamido-cephalosporins and penicillins
KR860000300B1 (en) * 1983-12-19 1986-03-31 김승호 Process for preparing acylureide penicillin derivatives

Also Published As

Publication number Publication date Type
FI54485B (en) 1978-08-31 application
LU63204A1 (en) 1971-09-01 application
NL7107176A (en) 1971-11-29 application
JPS55390B1 (en) 1980-01-08 grant
BE767648A (en) 1971-11-25 grant
GB1301962A (en) 1973-01-04 application
FI54485C (en) 1978-12-11 grant
ES411674A1 (en) 1976-01-01 application
ES391533A1 (en) 1974-08-01 application
FR2100682B1 (en) 1975-01-17 grant
CA932722A (en) 1973-08-28 grant
DK134438C (en) 1977-05-31 grant
ES411676A1 (en) 1976-01-01 application
FR2100682A1 (en) 1972-03-24 application
DK134438B (en) 1976-11-08 grant
CA932722A1 (en) grant
ES411675A1 (en) 1976-01-01 application
NL172659B (en) 1983-05-02 application
BE767648A1 (en) grant

Similar Documents

Publication Publication Date Title
US4018889A (en) Oxytetracycline compositions
GB1196229A (en) Improvements in or relating to a New Glyoxylic Acid Salt, process for its preparation and Therapeutical Composition containing same
GB1578739A (en) Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1390014A (en) Process for the preparation of carbocyclic fused pyrimidine derivatives
GB1169945A (en) Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives
US3142673A (en) Derivatives of 6-aminopenicillanic acid
US3157640A (en) D-(-)-alpha-aminobenzylpenicillin trihydrate
US3821198A (en) Derivatives of 6-amino penicillanic acid
US4002754A (en) Substituted piperazinyliminorifamycins
US3262928A (en) Process for the production of sodium alpha-aminobenzylpenicillin
US3068264A (en) Tetracycline antibiotic-aluminumphosphoric acid complexes
GB1416958A (en) Quinuclidine derivatives
GB1236078A (en) Substituted azetidinols
US4317775A (en) Amoxicillin derivatives
US3248387A (en) Amino-acylamino-penicillanic acids
GB1293446A (en) Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them
US3406183A (en) 3-n-arylamino-3-mercapto-2-cyanoacrylamides
US3911010A (en) Aminophenylamidines, their production and their pharmaceutical use
US2862967A (en) N-alkyl-n-(alkylated-benzyl)dihaloacetamides and preparation thereof
US3852433A (en) Uridine-5-monophosphate compositions
GB1437788A (en) Therapeutic compositions
US3432551A (en) 3,4,5-trimethoxybenzoylguanidines
GB1343527A (en) Amino-propanol derivatives
US3636049A (en) Isothiochroman carboxamides
US3461161A (en) Water-soluble tetracycline derivatives

Legal Events

Date Code Title Description
BK Erratum

Free format text: CORRECTION TO PAMPHLET

V1 Lapsed because of non-payment of the annual fee