GB1346317A - Peptide enzyme inhibitor - Google Patents
Peptide enzyme inhibitorInfo
- Publication number
- GB1346317A GB1346317A GB2260371A GB2260371A GB1346317A GB 1346317 A GB1346317 A GB 1346317A GB 2260371 A GB2260371 A GB 2260371A GB 2260371 A GB2260371 A GB 2260371A GB 1346317 A GB1346317 A GB 1346317A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pro
- gly
- synthesis
- pyroglu
- angiotensin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000002532 enzyme inhibitor Substances 0.000 title abstract 2
- 229940125532 enzyme inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102400000344 Angiotensin-1 Human genes 0.000 abstract 1
- 101800000734 Angiotensin-1 Proteins 0.000 abstract 1
- 102400000345 Angiotensin-2 Human genes 0.000 abstract 1
- 101800000733 Angiotensin-2 Proteins 0.000 abstract 1
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
- ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 1
- 229950006323 angiotensin ii Drugs 0.000 abstract 1
- 108010060035 arginylproline Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2086070A | 1970-03-18 | 1970-03-18 | |
| US6179470A | 1970-08-06 | 1970-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1346317A true GB1346317A (en) | 1974-02-06 |
Family
ID=26693975
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2260371A Expired GB1346317A (en) | 1970-03-18 | 1971-04-19 | Peptide enzyme inhibitor |
| GB3566573A Expired GB1346318A (en) | 1970-03-18 | 1971-04-19 | Intermediates for peptide enzyme inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3566573A Expired GB1346318A (en) | 1970-03-18 | 1971-04-19 | Intermediates for peptide enzyme inhibitors |
Country Status (6)
| Country | Link |
|---|---|
| JP (3) | JPS5725539B1 (enExample) |
| CA (1) | CA946836A (enExample) |
| CH (1) | CH536817A (enExample) |
| DE (1) | DE2108043C3 (enExample) |
| FR (1) | FR2085719B1 (enExample) |
| GB (2) | GB1346317A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| JPS59192608A (ja) * | 1983-04-15 | 1984-11-01 | Riiman Kk | 自動車用ホイ−ルカバ−の取付け方法 |
-
1971
- 1971-02-12 CA CA105,227A patent/CA946836A/en not_active Expired
- 1971-02-19 DE DE2108043A patent/DE2108043C3/de not_active Expired
- 1971-03-15 CH CH372671A patent/CH536817A/fr not_active IP Right Cessation
- 1971-03-18 JP JP1546571A patent/JPS5725539B1/ja active Pending
- 1971-03-18 FR FR7109594A patent/FR2085719B1/fr not_active Expired
- 1971-04-19 GB GB2260371A patent/GB1346317A/en not_active Expired
- 1971-04-19 GB GB3566573A patent/GB1346318A/en not_active Expired
-
1980
- 1980-03-11 JP JP3146880A patent/JPS55147249A/ja active Granted
- 1980-03-11 JP JP3147080A patent/JPS55143947A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55143947A (en) | 1980-11-10 |
| DE2108043B2 (de) | 1979-10-11 |
| JPS5727101B2 (enExample) | 1982-06-08 |
| GB1346318A (en) | 1974-02-06 |
| JPS55147249A (en) | 1980-11-17 |
| CH536817A (fr) | 1973-05-15 |
| CA946836A (en) | 1974-05-07 |
| JPS5727102B2 (enExample) | 1982-06-08 |
| FR2085719B1 (enExample) | 1976-04-16 |
| DE2108043C3 (de) | 1980-08-21 |
| JPS5725539B1 (enExample) | 1982-05-29 |
| DE2108043A1 (de) | 1971-09-30 |
| FR2085719A1 (enExample) | 1971-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |