GB1344603A - Carbamoyl oximes - Google Patents

Carbamoyl oximes

Info

Publication number
GB1344603A
GB1344603A GB2022272A GB2022272A GB1344603A GB 1344603 A GB1344603 A GB 1344603A GB 2022272 A GB2022272 A GB 2022272A GB 2022272 A GB2022272 A GB 2022272A GB 1344603 A GB1344603 A GB 1344603A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
acid addition
addition salts
pyrrolidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2022272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00141374A external-priority patent/US3823159A/en
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Publication of GB1344603A publication Critical patent/GB1344603A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1344603 Pyrrolidine derivatives USV PHARMACEUTICAL CORP 1 May 1972 [7 May 1971] 20222/72 Heading C2C Novel pyrrolidine derivatives of the formula wherein R 1 is nitrophenyl, R 2 is H, CH 3 or CH 2 CH 2 , R 3 is methoxyphenyl, and X is 1- pyrrolidinyl; and their pharmaceutically acceptable non-toxic acid addition salts are prepared by reacting oximes of the formula with either isocyanates of the formula or carbamoyl chlorides of the formula and, if desired, converting the resulting products in acid addition salts. Alternatively compounds in which R 2 is CH 3 may be obtained by methylating the corresponding compounds in which R 2 is H. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above novel compounds or acid addition salts thereof in admixture with suitable carriers or diluents. The compounds possess analgesic activity.
GB2022272A 1971-05-07 1972-05-01 Carbamoyl oximes Expired GB1344603A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00141374A US3823159A (en) 1969-11-18 1971-05-07 O-(substituted carbamoyl)-3-pyrrolidinopropio and butyrophenone oximes

Publications (1)

Publication Number Publication Date
GB1344603A true GB1344603A (en) 1974-01-23

Family

ID=22495416

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2022272A Expired GB1344603A (en) 1971-05-07 1972-05-01 Carbamoyl oximes

Country Status (3)

Country Link
CA (1) CA978974A (en)
GB (1) GB1344603A (en)
ZA (1) ZA722988B (en)

Also Published As

Publication number Publication date
ZA722988B (en) 1973-02-28
AU4185472A (en) 1973-11-08
CA978974A (en) 1975-12-02

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees