GB1335492A - Cyclocytidine compounds and process for making same - Google Patents
Cyclocytidine compounds and process for making sameInfo
- Publication number
- GB1335492A GB1335492A GB2476171*A GB2476171A GB1335492A GB 1335492 A GB1335492 A GB 1335492A GB 2476171 A GB2476171 A GB 2476171A GB 1335492 A GB1335492 A GB 1335492A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- cycloalkyl
- alkaryl
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KZOWNALBTMILAP-JBMRGDGGSA-N ancitabine hydrochloride Chemical class Cl.N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 KZOWNALBTMILAP-JBMRGDGGSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 229960002756 azacitidine Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052727 yttrium Inorganic materials 0.000 abstract 2
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
- OZQDLJNDRVBCST-SHUUEZRQSA-N 5-amino-2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazin-3-one Chemical compound O=C1N=C(N)C=NN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 OZQDLJNDRVBCST-SHUUEZRQSA-N 0.000 abstract 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- -1 cytidine compound Chemical class 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2120670A | 1970-03-19 | 1970-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1335492A true GB1335492A (en) | 1973-10-31 |
Family
ID=21802944
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4914772A Expired GB1335493A (en) | 1970-03-19 | 1971-04-19 | 1a-beta-d arabinofuranosyl cytosine derivatives and process for making same |
| GB2476171*A Expired GB1335492A (en) | 1970-03-19 | 1971-04-19 | Cyclocytidine compounds and process for making same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4914772A Expired GB1335493A (en) | 1970-03-19 | 1971-04-19 | 1a-beta-d arabinofuranosyl cytosine derivatives and process for making same |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3709874A (en:Method) |
| CA (1) | CA1024983A (en:Method) |
| CH (3) | CH559205A5 (en:Method) |
| DE (2) | DE2166717A1 (en:Method) |
| ES (1) | ES389383A1 (en:Method) |
| FR (1) | FR2085721B1 (en:Method) |
| GB (2) | GB1335493A (en:Method) |
| SE (1) | SE399558B (en:Method) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920630A (en) * | 1970-09-24 | 1975-11-18 | Upjohn Co | 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation |
| US3894000A (en) * | 1971-01-27 | 1975-07-08 | Upjohn Co | Ara-cytidine derivatives and process of preparation |
| SE399559B (sv) * | 1972-03-03 | 1978-02-20 | Syntex Corp | Sett att framstella oÿ2,2'-cyklocytidinforeningar |
| US3998807A (en) * | 1972-03-03 | 1976-12-21 | Syntex (U.S.A.) Inc. | Arabinofuranosyl cytosines and methods of making |
| US3899482A (en) * | 1972-09-05 | 1975-08-12 | Hoffmann La Roche | 2,2{40 -Anhydro-1-{62 D-arabinofuranosyl-5-fluorocytosine salts and process 2 |
| US4124757A (en) * | 1973-01-11 | 1978-11-07 | Hoffmann-La Roche Inc. | Process for preparing 2,2'-anhydro-1β-D-arabi nofuranosyl-5-fluorocytosine and salts |
| US4104461A (en) * | 1973-04-16 | 1978-08-01 | Research Corporation | 2,2'-Anhydro-β-D-arabinofuranosyl-5-fluorocytosine |
| JPS5344477B2 (en:Method) * | 1973-07-27 | 1978-11-29 | ||
| JPS535311B2 (en:Method) * | 1974-01-30 | 1978-02-25 | ||
| JPS5159880A (en) * | 1974-11-22 | 1976-05-25 | Asahi Chemical Ind | N44 ashirunukureoshidojikarubonsanesuteruno seiho |
| FR2531962B1 (fr) * | 1982-08-17 | 1986-11-14 | Sandoz Sa | Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments |
| US4704392A (en) * | 1985-04-30 | 1987-11-03 | Syntex (U.S.A.) Inc. | Tricyclic derivatives of substituted pyrimidines |
| US4914233A (en) * | 1988-03-01 | 1990-04-03 | Ethyl Corporation | Synthesis of beta-thymidine |
| US5008384A (en) * | 1988-07-12 | 1991-04-16 | Pfizer Inc. | Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine |
| JPH02256648A (ja) * | 1988-09-26 | 1990-10-17 | Occidental Chem Corp | 臭化２―アセトキシイソブチリルの製造方法 |
| EP0538194B1 (de) * | 1991-10-17 | 1997-06-04 | Novartis AG | Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte |
| AU2003278904A1 (en) * | 2002-09-24 | 2004-04-19 | Kornis Pharmaceuticals, Incorporated | 1, 3, 5-triazines for treatment of viral diseases |
| CN101250210B (zh) * | 2008-04-07 | 2011-01-12 | 郑州大学 | 5’－氯代核苷的合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR6132E (fr) * | 1906-02-05 | 1906-09-20 | Leon Serpollet | Système de chauffage des générateurs de vapeur, etc., au moyen des combustibles liquides |
-
1970
- 1970-03-19 US US00021206A patent/US3709874A/en not_active Expired - Lifetime
-
1971
- 1971-02-25 CA CA106,231A patent/CA1024983A/en not_active Expired
- 1971-03-17 DE DE19712166717 patent/DE2166717A1/de active Pending
- 1971-03-17 DE DE19712112724 patent/DE2112724A1/de active Pending
- 1971-03-18 ES ES389383A patent/ES389383A1/es not_active Expired
- 1971-03-18 FR FR7109546A patent/FR2085721B1/fr not_active Expired
- 1971-03-18 SE SE7103521A patent/SE399558B/xx unknown
- 1971-03-19 CH CH1158374A patent/CH559205A5/xx not_active IP Right Cessation
- 1971-03-19 CH CH407571A patent/CH567032A5/xx not_active IP Right Cessation
- 1971-03-19 CH CH1158474A patent/CH559206A5/xx not_active IP Right Cessation
- 1971-04-19 GB GB4914772A patent/GB1335493A/en not_active Expired
- 1971-04-19 GB GB2476171*A patent/GB1335492A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2112724A1 (de) | 1971-11-18 |
| SE399558B (sv) | 1978-02-20 |
| DE2166717A1 (de) | 1976-02-26 |
| ES389383A1 (es) | 1974-03-16 |
| CH559205A5 (en:Method) | 1975-02-28 |
| CA1024983A (en) | 1978-01-24 |
| CH559206A5 (en:Method) | 1975-02-28 |
| FR2085721A1 (en:Method) | 1971-12-31 |
| FR2085721B1 (en:Method) | 1975-10-10 |
| US3709874A (en) | 1973-01-09 |
| CH567032A5 (en:Method) | 1975-09-30 |
| GB1335493A (en) | 1973-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee | ||
| PCNP | Patent ceased through non-payment of renewal fee |