GB1334705A - Pharmaceutical compositions containing kynurenic acid derivatives - Google Patents
Pharmaceutical compositions containing kynurenic acid derivativesInfo
- Publication number
- GB1334705A GB1334705A GB1334705DA GB1334705A GB 1334705 A GB1334705 A GB 1334705A GB 1334705D A GB1334705D A GB 1334705DA GB 1334705 A GB1334705 A GB 1334705A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ester
- pharmaceutical compositions
- compositions containing
- acid derivatives
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HCZHHEIFKROPDY-UHFFFAOYSA-N kynurenic acid Chemical class C1=CC=C2NC(C(=O)O)=CC(=O)C2=C1 HCZHHEIFKROPDY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- -1 benzyloxy, acetyl Chemical group 0.000 abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- YTIVTFGABIZHHX-UHFFFAOYSA-N butynedioic acid Chemical compound OC(=O)C#CC(O)=O YTIVTFGABIZHHX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000002828 nitro derivatives Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2990570 | 1970-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1334705A true GB1334705A (en) | 1973-10-24 |
Family
ID=10299112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1334705D Expired GB1334705A (en) | 1970-06-19 | 1970-06-19 | Pharmaceutical compositions containing kynurenic acid derivatives |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2130408A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2100798B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1334705A (enrdf_load_stackoverflow) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4128649A (en) | 1977-06-29 | 1978-12-05 | Sandoz, Inc. | 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters |
| US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
| US4281131A (en) | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
| US4476132A (en) * | 1981-03-24 | 1984-10-09 | Ciba-Geigy Corporation | Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them |
| EP0303387A1 (en) * | 1987-08-12 | 1989-02-15 | Merck Sharp & Dohme Ltd. | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
| EP0339485A1 (en) * | 1988-04-26 | 1989-11-02 | The Du Pont Merck Pharmaceutical Company | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents |
| US4963566A (en) * | 1986-03-28 | 1990-10-16 | Otsuka Pharmaceutical Co., Ltd. | Benzimidazolyl-sulfinyl-tetrahydroquinolines |
| US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
| US5270309A (en) * | 1987-08-12 | 1993-12-14 | Merck Sharp & Dohme Limited | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US7056923B2 (en) | 2002-12-11 | 2006-06-06 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| WO2010128345A1 (en) * | 2009-05-05 | 2010-11-11 | Szegedi Tudományegyetem | Kynurenic acid analogues, pharmaceutical compositions containing same and use of said compounds for the treatment of headache |
| EP1851739A4 (en) * | 2004-12-29 | 2012-08-29 | Naturon Inc | PHARMACEUTICAL XANTHANIC ACID DERIVATIVE COMPOSITIONS AND RELATED METHODS |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3865831A (en) * | 1972-06-09 | 1975-02-11 | Upjohn Co | 1,1{40 ,4,4{40 -tetrahydro-4,4{40 -dioxo(6,6{40 biquinoline)-2,2{40 -dicarboxylates |
| FR2827599A1 (fr) * | 2001-07-20 | 2003-01-24 | Neuro3D | Composes derives de quinoleine et quinoxaline,preparation et utilisations |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1207771A (en) * | 1968-03-18 | 1970-10-07 | Warner Lambert Pharmaceutical | Anti-virally active quinoline derivatives |
-
1970
- 1970-06-19 GB GB1334705D patent/GB1334705A/en not_active Expired
-
1971
- 1971-06-18 DE DE19712130408 patent/DE2130408A1/de active Pending
- 1971-06-18 FR FR7122365A patent/FR2100798B1/fr not_active Expired
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
| US4281131A (en) | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
| US4128649A (en) | 1977-06-29 | 1978-12-05 | Sandoz, Inc. | 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters |
| US4476132A (en) * | 1981-03-24 | 1984-10-09 | Ciba-Geigy Corporation | Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them |
| EP0062001B1 (de) * | 1981-03-24 | 1987-05-27 | Ciba-Geigy Ag | Acyl-chinolinonderivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Verwendung |
| US4963566A (en) * | 1986-03-28 | 1990-10-16 | Otsuka Pharmaceutical Co., Ltd. | Benzimidazolyl-sulfinyl-tetrahydroquinolines |
| EP0303387A1 (en) * | 1987-08-12 | 1989-02-15 | Merck Sharp & Dohme Ltd. | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
| US5270309A (en) * | 1987-08-12 | 1993-12-14 | Merck Sharp & Dohme Limited | Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders |
| EP0339485A1 (en) * | 1988-04-26 | 1989-11-02 | The Du Pont Merck Pharmaceutical Company | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents |
| US5204329A (en) * | 1990-06-11 | 1993-04-20 | Du Pont Merck Pharmaceutical Company | Treatment of organ transplantation rejection |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US6995156B2 (en) | 2001-06-06 | 2006-02-07 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US7026323B2 (en) | 2001-06-06 | 2006-04-11 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US7176207B2 (en) | 2001-06-06 | 2007-02-13 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US7056923B2 (en) | 2002-12-11 | 2006-06-06 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| US7084142B2 (en) | 2002-12-11 | 2006-08-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| EP1851739A4 (en) * | 2004-12-29 | 2012-08-29 | Naturon Inc | PHARMACEUTICAL XANTHANIC ACID DERIVATIVE COMPOSITIONS AND RELATED METHODS |
| US8361734B2 (en) | 2004-12-29 | 2013-01-29 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
| US8697674B2 (en) | 2004-12-29 | 2014-04-15 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
| US10370335B2 (en) | 2004-12-29 | 2019-08-06 | Naturon, Inc. | Xanthurenic acid derivative pharmaceutical compositions and methods related thereto |
| WO2010128345A1 (en) * | 2009-05-05 | 2010-11-11 | Szegedi Tudományegyetem | Kynurenic acid analogues, pharmaceutical compositions containing same and use of said compounds for the treatment of headache |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2100798A1 (enrdf_load_stackoverflow) | 1972-03-24 |
| DE2130408A1 (de) | 1971-12-23 |
| FR2100798B1 (enrdf_load_stackoverflow) | 1975-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |