GB1328935A - Substituted cycloalkyl lactamimides - Google Patents
Substituted cycloalkyl lactamimidesInfo
- Publication number
- GB1328935A GB1328935A GB1691872A GB1691872A GB1328935A GB 1328935 A GB1328935 A GB 1328935A GB 1691872 A GB1691872 A GB 1691872A GB 1691872 A GB1691872 A GB 1691872A GB 1328935 A GB1328935 A GB 1328935A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- halogen
- alkyl
- prepared
- lactamimides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000005346 substituted cycloalkyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 1
- JLECCXUJWYXKRG-UHFFFAOYSA-N 2-hydroxy-2-phenylcyclopentan-1-one Chemical compound C=1C=CC=CC=1C1(O)CCCC1=O JLECCXUJWYXKRG-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14325971A | 1971-05-13 | 1971-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1328935A true GB1328935A (en) | 1973-09-05 |
Family
ID=22503285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1691872A Expired GB1328935A (en) | 1971-05-13 | 1972-04-12 | Substituted cycloalkyl lactamimides |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4126613A (enExample) |
| AU (1) | AU459590B2 (enExample) |
| BE (1) | BE783276A (enExample) |
| CA (1) | CA983036A (enExample) |
| CH (1) | CH568980A5 (enExample) |
| DE (1) | DE2219171A1 (enExample) |
| FR (1) | FR2137672B1 (enExample) |
| GB (1) | GB1328935A (enExample) |
| IL (1) | IL39243A (enExample) |
| NL (1) | NL7206462A (enExample) |
| ZA (1) | ZA722407B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007027651A3 (en) * | 2005-08-30 | 2007-05-31 | Abbott Lab | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816457A (en) * | 1973-01-05 | 1974-06-11 | Richardson Merrell Inc | Lactamimide derivatives |
| KR100342275B1 (ko) * | 1993-10-21 | 2002-12-05 | 지.디. 썰 엘엘씨 | 산화질소신타제저해제로서유용한아미디노유도체 |
| ATE246678T1 (de) * | 1995-04-20 | 2003-08-15 | Searle & Co | Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren |
| US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
| AU4821799A (en) | 1998-06-10 | 1999-12-30 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
| US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
| EP1394152A4 (en) * | 2001-04-19 | 2005-02-02 | Eisai Co Ltd | 2-IMINOIMIDAZOLE DERIVATIVES (1) |
| CA2515715C (en) * | 2003-02-19 | 2012-05-08 | Eisai Co., Ltd. | Methods for producing cyclic benzamidine derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1210848A (en) * | 1968-07-01 | 1970-11-04 | Mcneilab Inc | 2-imino-methyleneimines |
-
1972
- 1972-04-10 ZA ZA722407A patent/ZA722407B/xx unknown
- 1972-04-12 GB GB1691872A patent/GB1328935A/en not_active Expired
- 1972-04-18 IL IL39243A patent/IL39243A/xx unknown
- 1972-04-19 AU AU41325/72A patent/AU459590B2/en not_active Expired
- 1972-04-20 DE DE19722219171 patent/DE2219171A1/de active Pending
- 1972-04-24 CA CA140,395A patent/CA983036A/en not_active Expired
- 1972-04-24 CH CH606272A patent/CH568980A5/xx not_active IP Right Cessation
- 1972-05-09 FR FR7216532A patent/FR2137672B1/fr not_active Expired
- 1972-05-10 BE BE783276A patent/BE783276A/xx unknown
- 1972-05-12 NL NL7206462A patent/NL7206462A/xx not_active Application Discontinuation
-
1973
- 1973-08-09 US US05/386,995 patent/US4126613A/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007027651A3 (en) * | 2005-08-30 | 2007-05-31 | Abbott Lab | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
| JP2009508815A (ja) * | 2005-08-30 | 2009-03-05 | アボット・ラボラトリーズ | ジペプチジルペプチダーゼ−ｉｖ（ｄｐｐ−ｉｖ）の阻害薬としての医薬組成物 |
| US7834012B2 (en) | 2005-08-30 | 2010-11-16 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| AU2006285005B2 (en) * | 2005-08-30 | 2012-03-29 | Abbvie Inc. | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA722407B (en) | 1973-01-31 |
| BE783276A (fr) | 1972-09-01 |
| DE2219171A1 (de) | 1972-11-23 |
| US4126613A (en) | 1978-11-21 |
| CH568980A5 (enExample) | 1975-11-14 |
| CA983036A (en) | 1976-02-03 |
| IL39243A (en) | 1975-03-13 |
| AU459590B2 (en) | 1975-03-27 |
| FR2137672A1 (enExample) | 1972-12-29 |
| NL7206462A (enExample) | 1972-11-15 |
| FR2137672B1 (enExample) | 1975-06-20 |
| IL39243A0 (en) | 1972-06-28 |
| AU4132572A (en) | 1973-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |