GB1500359A - 4-aminopyrimidine derivatives - Google Patents

4-aminopyrimidine derivatives

Info

Publication number
GB1500359A
GB1500359A GB33227/75A GB3322775A GB1500359A GB 1500359 A GB1500359 A GB 1500359A GB 33227/75 A GB33227/75 A GB 33227/75A GB 3322775 A GB3322775 A GB 3322775A GB 1500359 A GB1500359 A GB 1500359A
Authority
GB
United Kingdom
Prior art keywords
compounds
aug
halogen
alkyl
aminopyrimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33227/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of GB1500359A publication Critical patent/GB1500359A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

1500359 Aminopyrimidinium compounds EISAI CO Ltd 8 Aug 1975 [9 Aug 1974] 33227/75 Heading C2C The invention comprises compounds of formula wherein R 1 and R 2 are each H or C 1-6 alkyl; R 3 and R 4 are each H, halogen, NO 2 , NH 2 or C 1-6 alkyl, alkoxy, alkyloxycarbonyl or alkylsulphonyl; and X is halogen. They are prepared by N<SP>1</SP>-quaternization of a 4-aminopyrimidine with a phenacyl halide. Therapeutic compositions having antiinflammatory and analgesic activity comprise compounds of the above formula, and may be administered orally.
GB33227/75A 1974-08-09 1975-08-08 4-aminopyrimidine derivatives Expired GB1500359A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49090783A JPS5854143B2 (en) 1974-08-09 1974-08-09 4- Aminopyrimidine

Publications (1)

Publication Number Publication Date
GB1500359A true GB1500359A (en) 1978-02-08

Family

ID=14008186

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33227/75A Expired GB1500359A (en) 1974-08-09 1975-08-08 4-aminopyrimidine derivatives

Country Status (5)

Country Link
US (1) US4038278A (en)
JP (1) JPS5854143B2 (en)
DE (1) DE2535571A1 (en)
FR (1) FR2281118A1 (en)
GB (1) GB1500359A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344938U (en) * 1989-09-07 1991-04-25

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3702361A (en) * 1969-11-21 1972-11-07 Monsanto Co Insecticidal methods using n-substituted heterocyclic phenacyl halides and ylids

Also Published As

Publication number Publication date
JPS5854143B2 (en) 1983-12-02
DE2535571A1 (en) 1976-02-26
JPS51125710A (en) 1976-11-02
US4038278A (en) 1977-07-26
FR2281118B1 (en) 1979-09-14
FR2281118A1 (en) 1976-03-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee