GB1324022A - Purification of tetracycline antibiotics - Google Patents
Purification of tetracycline antibioticsInfo
- Publication number
- GB1324022A GB1324022A GB4512270A GB4512270A GB1324022A GB 1324022 A GB1324022 A GB 1324022A GB 4512270 A GB4512270 A GB 4512270A GB 4512270 A GB4512270 A GB 4512270A GB 1324022 A GB1324022 A GB 1324022A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetracycline
- solution
- antibiotic
- produced
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940072172 tetracycline antibiotic Drugs 0.000 title abstract 6
- 238000000746 purification Methods 0.000 title abstract 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 4
- 239000012535 impurity Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 235000019364 tetracycline Nutrition 0.000 abstract 2
- 150000003522 tetracyclines Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 abstract 1
- 239000012984 antibiotic solution Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 1
- 235000019366 oxytetracycline Nutrition 0.000 abstract 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86295269A | 1969-10-01 | 1969-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1324022A true GB1324022A (en) | 1973-07-18 |
Family
ID=25339830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4512270A Expired GB1324022A (en) | 1969-10-01 | 1970-09-22 | Purification of tetracycline antibiotics |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2048355A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2070101B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1324022A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116621724A (zh) * | 2023-07-21 | 2023-08-22 | 山东国邦药业有限公司 | 一种降低杂质2-乙酰-2-去酰胺土霉素含量的土霉素提取方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH321004A (fr) * | 1953-09-12 | 1957-05-15 | Rhone Poulenc Chemicals | Procédé d'obtention du chlorhydrate de chlortétracycline |
| GB828911A (en) * | 1955-04-25 | 1960-02-24 | Olin Mathieson | Improvements in or relating to the purification and separation of tetracycline |
| GB1049434A (en) * | 1964-02-27 | 1966-11-30 | Farmaceutici Italia | Oxytetracycline |
-
1970
- 1970-09-22 GB GB4512270A patent/GB1324022A/en not_active Expired
- 1970-10-01 FR FR7035514A patent/FR2070101B1/fr not_active Expired
- 1970-10-01 DE DE19702048355 patent/DE2048355A1/de active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116621724A (zh) * | 2023-07-21 | 2023-08-22 | 山东国邦药业有限公司 | 一种降低杂质2-乙酰-2-去酰胺土霉素含量的土霉素提取方法 |
| CN116621724B (zh) * | 2023-07-21 | 2023-10-27 | 山东国邦药业有限公司 | 一种降低杂质2-乙酰-2-去酰胺土霉素含量的土霉素提取方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2070101A1 (enrdf_load_stackoverflow) | 1971-09-10 |
| DE2048355A1 (de) | 1971-04-15 |
| FR2070101B1 (enrdf_load_stackoverflow) | 1974-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |