GB1313056A - Pyrimidopyrimidines - Google Patents
PyrimidopyrimidinesInfo
- Publication number
- GB1313056A GB1313056A GB2066071A GB2066071A GB1313056A GB 1313056 A GB1313056 A GB 1313056A GB 2066071 A GB2066071 A GB 2066071A GB 2066071 A GB2066071 A GB 2066071A GB 1313056 A GB1313056 A GB 1313056A
- Authority
- GB
- United Kingdom
- Prior art keywords
- interchanged
- radical
- formula
- compound
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1313056 Pyrimidopyrimidines DR KARL THOMAE GmbH 19 April 1971 [30 Jan 1970] 20660/71 Heading C2C Compounds of the general formula (R 1 , 2 =C 1-3 alkyl, or NR 1 R 2 =1,2,5,6-tetrahydropyridino or hexamethyleneimino, or piperidino optionally substituted by 1 or 2 Me or Et; R 3 , 4 = dialkanolamino in which the hydroxyalkyl radicals each contain 2-6 C, provided that when R 3 = R 4 the group contains a C 4-6 hydroxyalkyl radical) are prepared by (a) reducing a compound of the formula and oxidizing the product, optionally followed by isomer separation, or (b) reacting a compound of the formula (A=radical which may be interchanged with NR 1 R 2 , A 1 =R 3 , A 2 =R 4 ; A=NR 1 R 2 , A 1 =R 3 , A 2 = radical which may be interchanged with R 4 ; A=NR 1 R 2 , A 2 =R 4 , A 1 =radical which may be interchanged with R 3 ; or A=NR 1 R 2 , A 1 , 2 =radicals which may be interchanged with R 3 (=R 4 )) with R 1 R 2 NH, R 3 H or R 4 H. The above compounds possess heart and circulation activity and inhibit thrombocyte aggregation. They may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702004201 DE2004201A1 (en) | 1970-01-30 | 1970-01-30 | New 2,6-bis (dialkanolamino) -pyrimido- [5,4-d] pyrimidines and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1313056A true GB1313056A (en) | 1973-04-11 |
Family
ID=5760961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2066071A Expired GB1313056A (en) | 1970-01-30 | 1971-04-19 | Pyrimidopyrimidines |
Country Status (13)
| Country | Link |
|---|---|
| AT (2) | AT302313B (en) |
| AU (1) | AU2476771A (en) |
| BE (1) | BE762327A (en) |
| BG (1) | BG18612A3 (en) |
| DE (1) | DE2004201A1 (en) |
| ES (2) | ES387409A1 (en) |
| FR (1) | FR2081471B1 (en) |
| GB (1) | GB1313056A (en) |
| HU (1) | HU163360B (en) |
| IL (1) | IL36097A0 (en) |
| NL (1) | NL7101118A (en) |
| RO (2) | RO57779A7 (en) |
| ZA (1) | ZA71579B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1116676B (en) * | 1955-03-14 | 1961-11-09 | Thomae Gmbh Dr K | Process for the preparation of pyrimido [5, 4-d] pyrimidines |
| GB1051218A (en) * | 1963-03-09 | |||
| SU429582A3 (en) * | 1968-07-31 | 1974-05-25 | Йозеф РОХ | METHOD FOR OBTAINING 2,6-5H-(DIALKANOLAMINO)PYRIMIDO[5,4-c{] PYRIMIDINE1 DERIVATIVES ?] pyrimidine described in the literature have the best pharmacological properties. A method is known for obtaining pyrimido[5,4-th]-pyrimidines of the general formula by reducing the compound of general formula-1 B10, where two of the radicals Ri, R2, Rs and R4 are a free or substituted amino group or a free or substituted hydrazino or guanidino group, and the other two are hydrogen or halogen, an alkyl or aryl radical, an hydroxy group free or substituted by an alkyl, Ery;!-yl'I diethylamioethyl group, a mercapto group, free or substituted by an alkyl or an aryl radical. npa and one more of the Zi, Z^, Zg and Z4 radicals is hydrogen or halogen, alkyl or aryl, an hydroxy group free or substituted by an alkyl, aryl or diethylaminoethyl group, a mercapto group free or substituted by an alkyl or aryl radical, or a free or substituted amino group. We propose a method. |
-
1970
- 1970-01-30 DE DE19702004201 patent/DE2004201A1/en active Pending
-
1971
- 1971-01-12 RO RO65570A patent/RO57779A7/ro unknown
- 1971-01-12 RO RO68283A patent/RO58069A7/ro unknown
- 1971-01-19 ES ES387409A patent/ES387409A1/en not_active Expired
- 1971-01-28 NL NL7101118A patent/NL7101118A/xx unknown
- 1971-01-28 AU AU24767/71A patent/AU2476771A/en not_active Expired
- 1971-01-28 BG BG16681A patent/BG18612A3/xx unknown
- 1971-01-29 AT AT76771A patent/AT302313B/en not_active IP Right Cessation
- 1971-01-29 BE BE762327A patent/BE762327A/en unknown
- 1971-01-29 AT AT1020971A patent/AT302336B/en not_active IP Right Cessation
- 1971-01-29 IL IL36097A patent/IL36097A0/en unknown
- 1971-01-29 HU HUTO840A patent/HU163360B/hu unknown
- 1971-01-29 FR FR7103038A patent/FR2081471B1/fr not_active Expired
- 1971-01-29 ZA ZA710579A patent/ZA71579B/en unknown
- 1971-02-20 ES ES388479A patent/ES388479A1/en not_active Expired
- 1971-04-19 GB GB2066071A patent/GB1313056A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES388479A1 (en) | 1973-05-01 |
| SU379093A3 (en) | 1973-04-18 |
| BG18612A3 (en) | 1975-02-25 |
| AU2476771A (en) | 1972-08-03 |
| DE2004201A1 (en) | 1971-08-05 |
| FR2081471B1 (en) | 1974-09-06 |
| HU163360B (en) | 1973-07-28 |
| RO58069A7 (en) | 1975-06-15 |
| RO57779A7 (en) | 1975-03-15 |
| AT302313B (en) | 1972-10-10 |
| NL7101118A (en) | 1971-08-03 |
| AT302336B (en) | 1972-10-10 |
| ES387409A1 (en) | 1973-05-16 |
| BE762327A (en) | 1971-07-29 |
| IL36097A0 (en) | 1971-03-24 |
| ZA71579B (en) | 1971-11-24 |
| FR2081471A1 (en) | 1971-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |