GB1308327A - Phenylalkane derivatives and processes for the preparation thereof - Google Patents
Phenylalkane derivatives and processes for the preparation thereofInfo
- Publication number
- GB1308327A GB1308327A GB1783270A GB1308327DA GB1308327A GB 1308327 A GB1308327 A GB 1308327A GB 1783270 A GB1783270 A GB 1783270A GB 1308327D A GB1308327D A GB 1308327DA GB 1308327 A GB1308327 A GB 1308327A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- chlorine
- atom
- group
- chlorine atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 5
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- CWWCQGGNKDBSNT-UHFFFAOYSA-N 2-(2-phenoxyphenyl)acetic acid Chemical class OC(=O)CC1=CC=CC=C1OC1=CC=CC=C1 CWWCQGGNKDBSNT-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- VQJMAIZOEPPELO-KYGIZGOZSA-N (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-(2-hydroxy-5-methylhexan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol hydrochloride Chemical compound Cl.CO[C@]12CC[C@@]3(C[C@@H]1C(C)(O)CCC(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 VQJMAIZOEPPELO-KYGIZGOZSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- KPBCVVSDGJBODL-UHFFFAOYSA-N 1-(2-phenoxyphenyl)ethanone Chemical compound CC(=O)C1=CC=CC=C1OC1=CC=CC=C1 KPBCVVSDGJBODL-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal phenolate Chemical class 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229940031826 phenolate Drugs 0.000 abstract 1
- 125000005323 thioketone group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1783270 | 1970-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1308327A true GB1308327A (en) | 1973-02-21 |
Family
ID=10101999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1783270A Expired GB1308327A (en) | 1970-04-14 | 1970-04-14 | Phenylalkane derivatives and processes for the preparation thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3766263A (enExample) |
| JP (1) | JPS536143B1 (enExample) |
| BE (1) | BE842952Q (enExample) |
| CA (1) | CA935438A (enExample) |
| FR (1) | FR2092044B1 (enExample) |
| GB (1) | GB1308327A (enExample) |
| HK (1) | HK51576A (enExample) |
| IE (1) | IE35123B1 (enExample) |
| KE (1) | KE2633A (enExample) |
| MY (1) | MY7600176A (enExample) |
| NL (1) | NL157006B (enExample) |
| SE (1) | SE372254B (enExample) |
| ZA (1) | ZA712345B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0057047A1 (en) * | 1981-01-24 | 1982-08-04 | Reckitt And Colman Products Limited | Process for the preparation of 2-(2,4-dichlorophenoxy) phenylacetic acid |
| EP0078477A3 (en) * | 1981-11-04 | 1983-06-22 | Miles Laboratories Inc. | Fenclofenac as tbp blocking agent in iodothyronine immunoassays |
| US4912136A (en) * | 1987-06-29 | 1990-03-27 | Wood Elizabeth M | Uses of a substituted 2-phenoxyphenylacetic acid as an immunosuppressant drug |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES431425A1 (es) * | 1973-10-29 | 1977-01-16 | Eisai Co Ltd | Un procedimiento para la preparacion de derivados del acido 2-(m-fenoxifenil)-propionico. |
| YU4075A (en) * | 1974-01-14 | 1982-06-30 | Isf Spa | Process for obtaining phenylacetic acid derivatives |
| US4065503A (en) * | 1974-09-30 | 1977-12-27 | Sandoz, Inc. | P-Phenoxy-alkylphenones and corresponding alcohols |
| US4430510A (en) | 1981-06-18 | 1984-02-07 | Schering Corporation | Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid |
| JPS60103906U (ja) * | 1983-12-20 | 1985-07-16 | 株式会社ヨコオ | アンテナ接続装置 |
| US5145790A (en) * | 1990-05-04 | 1992-09-08 | Abbott Laboratories | Reagents and method for detecting polychlorinated biphenyls |
| AU659106B2 (en) * | 1990-11-06 | 1995-05-11 | Fgn, Inc. | Method for treating colonic polyps by the use of esters and amides of substituted phenyl and pyridyl amino carboxylates |
| US5538852A (en) * | 1992-10-02 | 1996-07-23 | Ecochem Research, Inc. | Immunoassay for polychlorinated biphenyls |
| US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
| ITMI20012434A1 (it) * | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
| US20070259861A1 (en) | 2006-03-08 | 2007-11-08 | Pharmena North America Inc. | Combination therapy with non-selective COX inhibitors to prevent COX-related gastric injuries |
-
1970
- 1970-04-14 GB GB1783270A patent/GB1308327A/en not_active Expired
-
1971
- 1971-04-05 IE IE430/71A patent/IE35123B1/xx unknown
- 1971-04-08 CA CA109932A patent/CA935438A/en not_active Expired
- 1971-04-09 US US00132891A patent/US3766263A/en not_active Expired - Lifetime
- 1971-04-13 JP JP2340471A patent/JPS536143B1/ja active Pending
- 1971-04-13 NL NL7104884.A patent/NL157006B/xx not_active IP Right Cessation
- 1971-04-13 FR FR7112973A patent/FR2092044B1/fr not_active Expired
- 1971-04-13 SE SE7104757A patent/SE372254B/xx unknown
- 1971-04-13 ZA ZA712345A patent/ZA712345B/xx unknown
-
1976
- 1976-05-28 KE KE2633*UA patent/KE2633A/xx unknown
- 1976-06-14 BE BE6045556A patent/BE842952Q/xx not_active IP Right Cessation
- 1976-08-12 HK HK515/76*UA patent/HK51576A/xx unknown
- 1976-12-31 MY MY1976176A patent/MY7600176A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0057047A1 (en) * | 1981-01-24 | 1982-08-04 | Reckitt And Colman Products Limited | Process for the preparation of 2-(2,4-dichlorophenoxy) phenylacetic acid |
| US4404396A (en) * | 1981-01-24 | 1983-09-13 | Reckitt & Colman Products Limited | Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid |
| EP0078477A3 (en) * | 1981-11-04 | 1983-06-22 | Miles Laboratories Inc. | Fenclofenac as tbp blocking agent in iodothyronine immunoassays |
| US4912136A (en) * | 1987-06-29 | 1990-03-27 | Wood Elizabeth M | Uses of a substituted 2-phenoxyphenylacetic acid as an immunosuppressant drug |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7104884A (enExample) | 1971-10-18 |
| NL157006B (nl) | 1978-06-15 |
| FR2092044A1 (enExample) | 1972-01-21 |
| IE35123L (en) | 1971-10-14 |
| JPS536143B1 (enExample) | 1978-03-04 |
| FR2092044B1 (enExample) | 1975-08-01 |
| SE372254B (enExample) | 1974-12-16 |
| KE2633A (en) | 1976-06-11 |
| HK51576A (en) | 1976-08-20 |
| US3766263A (en) | 1973-10-16 |
| IE35123B1 (en) | 1975-11-12 |
| DE2117826A1 (de) | 1971-10-28 |
| MY7600176A (en) | 1976-12-31 |
| ZA712345B (en) | 1972-05-31 |
| BE842952Q (fr) | 1976-10-01 |
| CA935438A (en) | 1973-10-16 |
| DE2117826B2 (de) | 1975-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |