GB1301346A - - Google Patents
Info
- Publication number
- GB1301346A GB1301346A GB1301346DA GB1301346A GB 1301346 A GB1301346 A GB 1301346A GB 1301346D A GB1301346D A GB 1301346DA GB 1301346 A GB1301346 A GB 1301346A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacted
- trifluoroacetic acid
- ergot
- alkaloids
- nha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
1301346 Ergot alkaloids SANDOZ Ltd 17 April 1970 [6 May 1969 2 July 1969] 18417/70 Heading C2C In a process for preparing compounds (I) wherein #x y is -CH 2 -CH< or -CH=C<; R 1 is H, alkyl, allyl or benzyl, and -NHA is a polypeptide of cyclic structure known in ergot peptide alkaloids, a compound (III): wherein #z x #y is >CH-CH=C< or >C= CH-CH< or >CH-CH 2 -CH< is reacted with trifluoroacetic acid anhydride in the presence of trifluoroacetic acid and the mixed anhydride formed is reacted with H-NH-A (II) in the presence of a tertiary organic base, each stage of the reaction being effected in an inert solvent and at - 20‹ to +10‹ C.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH691269A CH530374A (en) | 1969-05-06 | 1969-05-06 | Ergot alkaloids |
| CH1011869 | 1969-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1301346A true GB1301346A (en) | 1972-12-29 |
Family
ID=25700377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1301346D Expired GB1301346A (en) | 1969-05-06 | 1970-04-17 |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE749920A (en) |
| CS (1) | CS152357B2 (en) |
| DE (1) | DE2021706C2 (en) |
| DK (1) | DK132029C (en) |
| FR (1) | FR2047237A5 (en) |
| GB (1) | GB1301346A (en) |
| HU (1) | HU162310B (en) |
| NL (1) | NL167438C (en) |
| PL (1) | PL80563B1 (en) |
| SE (1) | SE382634B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH601321A5 (en) * | 1975-01-06 | 1978-07-14 | Sandoz Ag |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2736728A (en) * | 1954-12-06 | 1956-02-28 | Lilly Co Eli | Preparation of lysergic acid amides |
| US2997470A (en) * | 1956-03-05 | 1961-08-22 | Lilly Co Eli | Lysergic acid amides |
-
1970
- 1970-04-17 GB GB1301346D patent/GB1301346A/en not_active Expired
- 1970-04-27 NL NL7006077A patent/NL167438C/en not_active IP Right Cessation
- 1970-05-04 DE DE19702021706 patent/DE2021706C2/en not_active Expired
- 1970-05-04 BE BE749920D patent/BE749920A/en not_active IP Right Cessation
- 1970-05-04 SE SE607570A patent/SE382634B/en unknown
- 1970-05-04 PL PL14041270A patent/PL80563B1/pl unknown
- 1970-05-04 CS CS307570A patent/CS152357B2/cs unknown
- 1970-05-04 FR FR7016159A patent/FR2047237A5/fr not_active Expired
- 1970-05-05 HU HUSA002084 patent/HU162310B/hu unknown
- 1970-05-05 DK DK229470A patent/DK132029C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL167438C (en) | 1981-12-16 |
| SE382634B (en) | 1976-02-09 |
| DE2021706C2 (en) | 1983-08-25 |
| NL7006077A (en) | 1970-11-10 |
| CS152357B2 (en) | 1973-12-19 |
| FR2047237A5 (en) | 1971-03-12 |
| PL80563B1 (en) | 1975-08-30 |
| DK132029C (en) | 1976-03-01 |
| DK132029B (en) | 1975-10-13 |
| NL167438B (en) | 1981-07-16 |
| HU162310B (en) | 1973-01-29 |
| BE749920A (en) | 1970-11-04 |
| DE2021706A1 (en) | 1970-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |