GB1299041A - Fused ring indole derivatives and a process for the manufacture thereof - Google Patents
Fused ring indole derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1299041A GB1299041A GB06567/71A GB1656771A GB1299041A GB 1299041 A GB1299041 A GB 1299041A GB 06567/71 A GB06567/71 A GB 06567/71A GB 1656771 A GB1656771 A GB 1656771A GB 1299041 A GB1299041 A GB 1299041A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- compounds
- manufacture
- haloacyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 2
- 125000005252 haloacyl group Chemical group 0.000 abstract 2
- -1 3-substituted cyclopentanone Chemical class 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000609 carbazolyl group Chemical class C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 abstract 1
- 229940067157 phenylhydrazine Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4044370A | 1970-05-25 | 1970-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1299041A true GB1299041A (en) | 1972-12-06 |
Family
ID=21911008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB06567/71A Expired GB1299041A (en) | 1970-05-25 | 1971-05-24 | Fused ring indole derivatives and a process for the manufacture thereof |
Country Status (14)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
| CN116854622A (zh) * | 2023-07-10 | 2023-10-10 | 青岛科技大学 | 一种多取代的2,4-二氢环戊二烯并[b]吲哚类化合物的合成方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2226703A1 (de) * | 1972-05-25 | 1973-12-13 | Schering Ag | Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung |
| DE3631824A1 (de) * | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
| AU675141B2 (en) * | 1993-07-20 | 1997-01-23 | Adir Et Compagnie | (Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them |
| US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
-
1971
- 1971-05-14 CH CH720271A patent/CH586678A5/xx not_active IP Right Cessation
- 1971-05-17 ZA ZA713173A patent/ZA713173B/xx unknown
- 1971-05-19 FR FR7118182A patent/FR2100677B1/fr not_active Expired
- 1971-05-20 IL IL36926A patent/IL36926A/xx unknown
- 1971-05-21 IE IE645/71A patent/IE36011B1/xx unknown
- 1971-05-24 JP JP46034844A patent/JPS5220476B1/ja active Pending
- 1971-05-24 AT AT445271A patent/AT310153B/de not_active IP Right Cessation
- 1971-05-24 GB GB06567/71A patent/GB1299041A/en not_active Expired
- 1971-05-24 ES ES391496A patent/ES391496A1/es not_active Expired
- 1971-05-24 BE BE767527A patent/BE767527A/xx unknown
- 1971-05-25 CA CA113,754A patent/CA952910A/en not_active Expired
- 1971-05-25 NL NL7107138A patent/NL7107138A/xx not_active Application Discontinuation
- 1971-05-25 HU HUHO1379A patent/HU163710B/hu unknown
- 1971-05-25 DE DE19712125926 patent/DE2125926A1/de not_active Ceased
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
| US4547576A (en) * | 1983-01-04 | 1985-10-15 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tetrahydrocarbazole derivatives |
| US4618614A (en) * | 1983-01-04 | 1986-10-21 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Method of treating psychosis using tetrahydrocarbazole derivatives |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
| CN116854622A (zh) * | 2023-07-10 | 2023-10-10 | 青岛科技大学 | 一种多取代的2,4-二氢环戊二烯并[b]吲哚类化合物的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2100677A1 (enrdf_load_stackoverflow) | 1972-03-24 |
| ES391496A1 (es) | 1973-06-16 |
| IE36011B1 (en) | 1976-07-21 |
| AT310153B (de) | 1973-09-25 |
| JPS5220476B1 (enrdf_load_stackoverflow) | 1977-06-03 |
| NL7107138A (enrdf_load_stackoverflow) | 1971-11-29 |
| BE767527A (fr) | 1971-11-24 |
| FR2100677B1 (enrdf_load_stackoverflow) | 1974-10-18 |
| IL36926A0 (en) | 1971-07-28 |
| CA952910A (en) | 1974-08-13 |
| ZA713173B (en) | 1972-01-26 |
| DE2125926A1 (de) | 1972-01-27 |
| HU163710B (enrdf_load_stackoverflow) | 1973-10-27 |
| IE36011L (en) | 1971-11-25 |
| CH586678A5 (enrdf_load_stackoverflow) | 1977-04-15 |
| IL36926A (en) | 1974-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SPA | Amended specification published | ||
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |