IE36011L - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
IE36011L
IE36011L IE710645A IE64571A IE36011L IE 36011 L IE36011 L IE 36011L IE 710645 A IE710645 A IE 710645A IE 64571 A IE64571 A IE 64571A IE 36011 L IE36011 L IE 36011L
Authority
IE
Ireland
Prior art keywords
alkyl
alkoxy
compounds
haloacyl
chy
Prior art date
Application number
IE710645A
Other versions
IE36011B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE36011L publication Critical patent/IE36011L/en
Publication of IE36011B1 publication Critical patent/IE36011B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1299041 Derivatives of carbazole and cycle. penta[b]indole F HOFFMANN-LA ROCHE & CO AG 24 May 1971 [25 May 1970] 16567/71 Heading C2C The invention comprises compounds of formula and their enantiomers and salts, wherein n and r are each 1 or 2; R<SP>1</SP> is halogen, OH, CN, C 1-7 alkyl, alkoxy or alkylthio, PhCH 2 O, CF 3 , CO 2 H, CO 2 (C 1-7 alkyl), NO 2 , NH a , C 1-7 alkylamino, di(C 1-7 alkyl)amino, SO 2 NH 2 , SO 2 N(C 1-7 alkyl) 2 or CHF 2 SO 2 , or (r=2) 2 adjacent R<SP>1</SP> represent C 1-4 alkylenedioxy; R<SP>2</SP> is H, C 1-7 alkyl, acyl, haloacyl, aralkyl or haloaralkyl; and R<SP>3</SP> is (CHY) m- A or (CHY) p -CO-B, where A is CN, OH or C 1-7 alkoxy, Y is H or Me, m and p are each 0-7 and B is OH, CO 2 H, C 1-7 alkyl or alkoxy, X 2 N or X 2 N-C 1-7 -alkyl, where each X is H or C 1-7 alkyl, provided that when R<SP>2</SP> is H, acyl or haloacyl, R<SP>1</SP> is not alkoxy. These compounds are prepared by reacting together a phenylhydrazine with a 3-substituted cyclopentanone or cyclohexanone, and optionally converting functional groups in the product to other groups, by known means. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have anti-inflammatory, analgesic and antirheumatic activity. [GB1299041A]
IE645/71A 1970-05-25 1971-05-21 Fused ring indole derivatives and a process for the manufacture thereof IE36011B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4044370A 1970-05-25 1970-05-25

Publications (2)

Publication Number Publication Date
IE36011L true IE36011L (en) 1971-11-25
IE36011B1 IE36011B1 (en) 1976-07-21

Family

ID=21911008

Family Applications (1)

Application Number Title Priority Date Filing Date
IE645/71A IE36011B1 (en) 1970-05-25 1971-05-21 Fused ring indole derivatives and a process for the manufacture thereof

Country Status (14)

Country Link
JP (1) JPS5220476B1 (en)
AT (1) AT310153B (en)
BE (1) BE767527A (en)
CA (1) CA952910A (en)
CH (1) CH586678A5 (en)
DE (1) DE2125926A1 (en)
ES (1) ES391496A1 (en)
FR (1) FR2100677B1 (en)
GB (1) GB1299041A (en)
HU (1) HU163710B (en)
IE (1) IE36011B1 (en)
IL (1) IL36926A (en)
NL (1) NL7107138A (en)
ZA (1) ZA713173B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2226703A1 (en) * 1972-05-25 1973-12-13 Schering Ag NEW TETRAHYDROCARBAZOLE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
EP0115607A1 (en) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazol derivatives
DE3631824A1 (en) * 1986-02-21 1988-03-31 Bayer Ag CYCLOALKANO (1.2-B) INDOL-SULFONAMIDE
AU675141B2 (en) * 1993-07-20 1997-01-23 Adir Et Compagnie (Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
WO2013059245A1 (en) 2011-10-17 2013-04-25 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer
CN116854622A (en) * 2023-07-10 2023-10-10 青岛科技大学 Synthesis method of polysubstituted 2, 4-dihydro-cyclopenta [ b ] indole compound

Also Published As

Publication number Publication date
ZA713173B (en) 1972-01-26
IE36011B1 (en) 1976-07-21
DE2125926A1 (en) 1972-01-27
CA952910A (en) 1974-08-13
HU163710B (en) 1973-10-27
IL36926A (en) 1974-10-22
AT310153B (en) 1973-09-25
CH586678A5 (en) 1977-04-15
FR2100677B1 (en) 1974-10-18
IL36926A0 (en) 1971-07-28
BE767527A (en) 1971-11-24
JPS5220476B1 (en) 1977-06-03
FR2100677A1 (en) 1972-03-24
GB1299041A (en) 1972-12-06
ES391496A1 (en) 1973-06-16
NL7107138A (en) 1971-11-29

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