GB1291281A - Improvements in pharmaceutical compositions - Google Patents
Improvements in pharmaceutical compositionsInfo
- Publication number
- GB1291281A GB1291281A GB04670/69A GB1467069A GB1291281A GB 1291281 A GB1291281 A GB 1291281A GB 04670/69 A GB04670/69 A GB 04670/69A GB 1467069 A GB1467069 A GB 1467069A GB 1291281 A GB1291281 A GB 1291281A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sodium
- potassium
- citrate
- carbo
- penicillin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 3
- -1 arylmethyl penicillin Chemical class 0.000 abstract 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 229930182555 Penicillin Natural products 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000001509 sodium citrate Substances 0.000 abstract 2
- 229940038773 trisodium citrate Drugs 0.000 abstract 2
- 235000019263 trisodium citrate Nutrition 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 abstract 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 abstract 1
- 239000004141 Sodium laurylsulphate Substances 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000003139 buffering effect Effects 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 239000000084 colloidal system Substances 0.000 abstract 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 abstract 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 abstract 1
- 235000019797 dipotassium phosphate Nutrition 0.000 abstract 1
- UZLGHNUASUZUOR-UHFFFAOYSA-L dipotassium;3-carboxy-3-hydroxypentanedioate Chemical compound [K+].[K+].OC(=O)CC(O)(C([O-])=O)CC([O-])=O UZLGHNUASUZUOR-UHFFFAOYSA-L 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000019371 penicillin G benzathine Nutrition 0.000 abstract 1
- 229940056360 penicillin g Drugs 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 239000001508 potassium citrate Substances 0.000 abstract 1
- 229960002635 potassium citrate Drugs 0.000 abstract 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 abstract 1
- 235000011082 potassium citrates Nutrition 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000002278 tabletting lubricant Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 abstract 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB04670/69A GB1291281A (en) | 1969-03-20 | 1969-03-20 | Improvements in pharmaceutical compositions |
| IL34089A IL34089A (en) | 1969-03-20 | 1970-03-16 | Pharmaceutical compositions containing penicillin or cephalosphorin derivatives |
| FI700775A FI51653C (fi) | 1969-03-20 | 1970-03-19 | Menetelmä suun kautta annostettavan penisilliini- tai kefalosporiinita bletin valmistamiseksi. |
| DK138070AA DK128674B (da) | 1969-03-20 | 1970-03-19 | Fremgangsmåde til fremstilling af tabletter indeholdende vandopløselige salte af α-carboxyester-substituerede phenylmethyl-penicilliner eller α-carboxyester-substituerede phenylmethyl-cephalosporiner til oral indgivning. |
| BE747656D BE747656A (fr) | 1969-03-20 | 1970-03-19 | Compositions pharmaceutiques ameliorees comprenant un sel hydrosoluble d'un compose acide actif et un excipient hydrosoluble ( |
| DE19702013039 DE2013039A1 (de) | 1969-03-20 | 1970-03-19 | Arzneimitteltablette zur oralen Verabreichung |
| FR7010069A FR2035118B1 (enrdf_load_stackoverflow) | 1969-03-20 | 1970-03-20 | |
| ES377725A ES377725A1 (es) | 1969-03-20 | 1970-03-20 | Un procedimiento para preparar una tableta adecuada para administracion oral. |
| SE7003870A SE379284B (enrdf_load_stackoverflow) | 1969-03-20 | 1970-03-20 | |
| NL707004004A NL143419B (nl) | 1969-03-20 | 1970-03-20 | Werkwijze voor het bereiden van een penicilline-preparaat in de vorm van een tablet door een in water oplosbaar zout van een penicilline en een in water oplosbaar buffermiddel tot een tablet te verwerken, alsmede aldus verkregen tabletten. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB04670/69A GB1291281A (en) | 1969-03-20 | 1969-03-20 | Improvements in pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1291281A true GB1291281A (en) | 1972-10-04 |
Family
ID=10045462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB04670/69A Expired GB1291281A (en) | 1969-03-20 | 1969-03-20 | Improvements in pharmaceutical compositions |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE747656A (enrdf_load_stackoverflow) |
| DE (1) | DE2013039A1 (enrdf_load_stackoverflow) |
| DK (1) | DK128674B (enrdf_load_stackoverflow) |
| ES (1) | ES377725A1 (enrdf_load_stackoverflow) |
| FI (1) | FI51653C (enrdf_load_stackoverflow) |
| FR (1) | FR2035118B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1291281A (enrdf_load_stackoverflow) |
| IL (1) | IL34089A (enrdf_load_stackoverflow) |
| NL (1) | NL143419B (enrdf_load_stackoverflow) |
| SE (1) | SE379284B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424075A (en) * | 1991-03-27 | 1995-06-13 | Miles Inc. | Delivery system for enhanced onset and increased potency |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2083622B1 (enrdf_load_stackoverflow) * | 1970-03-27 | 1975-08-22 | Sankyo Co | |
| US3940483A (en) | 1971-02-05 | 1976-02-24 | E. R. Squibb & Sons, Inc. | Antibiotic compositions and method |
| US3969524A (en) * | 1974-08-13 | 1976-07-13 | Hoffmann-La Roche Inc. | Stable amoxicillin dosage form |
| JPS5329936A (en) * | 1976-08-31 | 1978-03-20 | Takeda Chem Ind Ltd | Antibiotic composition |
| EP0012495B1 (en) * | 1978-12-08 | 1983-06-22 | Beecham Group Plc | Pharmaceutical composition comprising a water soluble salt of amoxycillin and polyvinylpyrrolidone, and a vial containing a unit dose of said composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2438106A (en) * | 1944-06-09 | 1948-03-23 | Wyeth Corp | Peroral penicillin compositions |
| US2864744A (en) * | 1955-09-02 | 1958-12-16 | American Home Prod | Penicillin in solid dosage unit form |
| US3131123A (en) * | 1959-03-13 | 1964-04-28 | Lab Francais De Therapeutique | Enteric tablets and manufacture thereof |
| GB1276839A (en) * | 1968-08-02 | 1972-06-07 | Sandoz Products Ltd | Antibiotic compositions |
-
1969
- 1969-03-20 GB GB04670/69A patent/GB1291281A/en not_active Expired
-
1970
- 1970-03-16 IL IL34089A patent/IL34089A/xx unknown
- 1970-03-19 DK DK138070AA patent/DK128674B/da not_active IP Right Cessation
- 1970-03-19 BE BE747656D patent/BE747656A/xx not_active IP Right Cessation
- 1970-03-19 DE DE19702013039 patent/DE2013039A1/de active Pending
- 1970-03-19 FI FI700775A patent/FI51653C/fi active
- 1970-03-20 FR FR7010069A patent/FR2035118B1/fr not_active Expired
- 1970-03-20 SE SE7003870A patent/SE379284B/xx unknown
- 1970-03-20 NL NL707004004A patent/NL143419B/xx not_active IP Right Cessation
- 1970-03-20 ES ES377725A patent/ES377725A1/es not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424075A (en) * | 1991-03-27 | 1995-06-13 | Miles Inc. | Delivery system for enhanced onset and increased potency |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7004004A (enrdf_load_stackoverflow) | 1970-09-22 |
| DK128674B (da) | 1974-06-17 |
| ES377725A1 (es) | 1972-10-16 |
| FR2035118B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| BE747656A (fr) | 1970-09-21 |
| IL34089A (en) | 1974-05-16 |
| SE379284B (enrdf_load_stackoverflow) | 1975-10-06 |
| NL143419B (nl) | 1974-10-15 |
| FI51653B (enrdf_load_stackoverflow) | 1976-11-30 |
| FR2035118A1 (enrdf_load_stackoverflow) | 1970-12-18 |
| DE2013039A1 (de) | 1970-09-24 |
| IL34089A0 (en) | 1970-05-21 |
| FI51653C (fi) | 1977-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |