GB1268608A - 5-amino-4-aroyl-1,3-dialkylpyrazoles - Google Patents
5-amino-4-aroyl-1,3-dialkylpyrazolesInfo
- Publication number
- GB1268608A GB1268608A GB23088/70A GB2308870A GB1268608A GB 1268608 A GB1268608 A GB 1268608A GB 23088/70 A GB23088/70 A GB 23088/70A GB 2308870 A GB2308870 A GB 2308870A GB 1268608 A GB1268608 A GB 1268608A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- reaction
- prepared
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 7
- 238000006243 chemical reaction Methods 0.000 abstract 5
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- -1 2-chloro-3-methoxyphenyl Chemical group 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82468769A | 1969-05-14 | 1969-05-14 | |
| US2401270A | 1970-03-30 | 1970-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1268608A true GB1268608A (en) | 1972-03-29 |
Family
ID=26697913
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23088/70A Expired GB1268608A (en) | 1969-05-14 | 1970-05-13 | 5-amino-4-aroyl-1,3-dialkylpyrazoles |
| GB23086/70A Expired GB1268607A (en) | 1969-05-14 | 1970-05-13 | NEW PYRAZOLO[3,4-e][1,4]DIAZEPIN-7(1H)-ONE COMPOUNDS AND METHODS FOR THEIR PRODUCTION |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23086/70A Expired GB1268607A (en) | 1969-05-14 | 1970-05-13 | NEW PYRAZOLO[3,4-e][1,4]DIAZEPIN-7(1H)-ONE COMPOUNDS AND METHODS FOR THEIR PRODUCTION |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US3558605A (enExample) |
| AT (4) | AT298500B (enExample) |
| BE (1) | BE750367A (enExample) |
| CH (4) | CH510040A (enExample) |
| DE (1) | DE2023453C3 (enExample) |
| FR (1) | FR2051523B1 (enExample) |
| GB (2) | GB1268608A (enExample) |
| NL (1) | NL148320B (enExample) |
| SE (1) | SE380016B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068806A3 (en) * | 1981-06-26 | 1983-08-10 | Warner-Lambert Company | Basic acyl amides of (5-amino-1,3-dialkylpyrazol-4-yl)(aryl)methanones, processes for their production, and pharmaceutical compositions containing such compounds |
| EP0623600A1 (de) * | 1993-05-05 | 1994-11-09 | Hüls Aktiengesellschaft | Verfahren zur Herstellung von 3-Amino-5-methylpyrazol |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2184392A1 (en) * | 1972-05-15 | 1973-12-28 | Abbott Lab | 1,3-dimethyl-5-methylamino-8-phenylpyrazolo (4,3-e)(1,4)diazepine-ant |
| US3823157A (en) * | 1972-12-15 | 1974-07-09 | Wald H De | Pyrazolodiazepine compounds and methods for their production |
| US3879535A (en) * | 1973-02-20 | 1975-04-22 | Parke Davis & Co | Anesthetic compositions and methods of use |
| US3873565A (en) * | 1973-05-16 | 1975-03-25 | Parke Davis & Co | Pyrazolodiazocine compounds |
| DE2747531A1 (de) * | 1977-10-22 | 1979-04-26 | Basf Ag | Substituierte 3-aminopyrazole |
| DE2932835A1 (de) * | 1979-08-14 | 1981-03-26 | Hoechst Ag, 65929 Frankfurt | Neue 4-aryl-5,6,7,8-tetrahydropyrazolo(3,4-b)diazepin-1h,4h-5,7-dione und verfahren zu ihrer darstellung |
| US4900836A (en) * | 1983-06-23 | 1990-02-13 | American Cyanamid Company | (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| NZ208555A (en) * | 1983-06-23 | 1987-06-30 | American Cyanamid Co | (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives |
| US4980472A (en) * | 1983-06-23 | 1990-12-25 | American Cyanamid Company | Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
-
1969
- 1969-05-14 US US824687A patent/US3558605A/en not_active Expired - Lifetime
-
1970
- 1970-03-30 US US24012A patent/US3660425A/en not_active Expired - Lifetime
- 1970-05-13 AT AT463171A patent/AT298500B/de not_active IP Right Cessation
- 1970-05-13 AT AT04633/71A patent/AT297719B/de not_active IP Right Cessation
- 1970-05-13 AT AT430570A patent/AT297709B/de not_active IP Right Cessation
- 1970-05-13 SE SE7006517A patent/SE380016B/xx unknown
- 1970-05-13 CH CH711170A patent/CH510040A/fr not_active IP Right Cessation
- 1970-05-13 DE DE2023453A patent/DE2023453C3/de not_active Expired
- 1970-05-13 FR FR7017382A patent/FR2051523B1/fr not_active Expired
- 1970-05-13 AT AT463271A patent/AT299961B/de not_active IP Right Cessation
- 1970-05-13 CH CH756571A patent/CH522665A/de not_active IP Right Cessation
- 1970-05-13 NL NL707006933A patent/NL148320B/xx not_active IP Right Cessation
- 1970-05-13 BE BE750367D patent/BE750367A/xx not_active IP Right Cessation
- 1970-05-13 GB GB23088/70A patent/GB1268608A/en not_active Expired
- 1970-05-13 CH CH756371A patent/CH522663A/fr not_active IP Right Cessation
- 1970-05-13 GB GB23086/70A patent/GB1268607A/en not_active Expired
- 1970-05-13 CH CH756471A patent/CH522664A/fr not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068806A3 (en) * | 1981-06-26 | 1983-08-10 | Warner-Lambert Company | Basic acyl amides of (5-amino-1,3-dialkylpyrazol-4-yl)(aryl)methanones, processes for their production, and pharmaceutical compositions containing such compounds |
| EP0623600A1 (de) * | 1993-05-05 | 1994-11-09 | Hüls Aktiengesellschaft | Verfahren zur Herstellung von 3-Amino-5-methylpyrazol |
Also Published As
| Publication number | Publication date |
|---|---|
| AT297709B (de) | 1972-04-10 |
| CH522663A (fr) | 1972-05-15 |
| CH522665A (de) | 1972-05-15 |
| CH522664A (fr) | 1972-05-15 |
| US3660425A (en) | 1972-05-02 |
| DE2023453C3 (de) | 1975-04-10 |
| AT299961B (de) | 1972-07-10 |
| NL7006933A (enExample) | 1970-11-17 |
| NL148320B (nl) | 1976-01-15 |
| SE380016B (enExample) | 1975-10-27 |
| BE750367A (fr) | 1970-10-16 |
| GB1268607A (en) | 1972-03-29 |
| AT298500B (de) | 1972-05-10 |
| FR2051523B1 (enExample) | 1974-04-12 |
| CH510040A (fr) | 1971-07-15 |
| DE2023453B2 (de) | 1974-09-05 |
| AT297719B (de) | 1972-03-15 |
| US3558605A (en) | 1971-01-26 |
| FR2051523A1 (enExample) | 1971-04-09 |
| DE2023453A1 (de) | 1970-11-19 |
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