GB1265764A - - Google Patents

Info

Publication number
GB1265764A
GB1265764A GB1265764DA GB1265764A GB 1265764 A GB1265764 A GB 1265764A GB 1265764D A GB1265764D A GB 1265764DA GB 1265764 A GB1265764 A GB 1265764A
Authority
GB
United Kingdom
Prior art keywords
group
hydroxy
general formula
hydrogen atom
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1265764A publication Critical patent/GB1265764A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,265,764. Mandelamidines. ORSYMONDE. 20 April, 1970 [23 April, 1969], No. 18696/70. Addition to 1,243,186. Heading C2C. Novel mandelamidines of the general formula wherein R 1 and R 2 are each a hydrogen atom or a hydroxy, C 1-3 alkyl or C 1-3 alkoxy group or together represent a C 1-3 alkylenedioxy group, R 3 is a hydrogen atom or a C 1-3 alkyl or phenyl group and R 4 is a hydroxy, C 2-3 alkyl or phenyl group or, when R 2 is a hydroxy or C 1-3 alkoxy group and R 1 is a hydrogen atom or when R 2 is a hydroxy group and R 1 is a C 1-3 alkoxy group or when R 1 and R2 are together a C 1-3 alkylenedioxy group, R 4 may be a hydrogen atom or methyl group, and non-toxic acid addition salts thereof are prepared (a) when R 4 is not a hydroxy group, by reaction of a mandelonitrile of the general formula with an aliphatic alcohol, followed by ammonia or an amine of the general formula NHR 3 R 4 ; and (b) when R 4 is a hydroxy group, by reaction of the corresponding mandelamidine of the first general formula above wherein R 4 is a hydrogen atom with hydroxylamine; followed optionally by salification of the product or resolution into its optically active forms. Pharmaceutical compositions, useful in the treatment of arterial hypertension, comprise, as active ingredient, at least one mandelamidine of the first general formula above or non-toxic acid addition salt thereof, together with a non- toxic pharmaceutical carrier.
GB1265764D 1969-04-23 1970-04-20 Expired GB1265764A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6912850A FR2036958A6 (en) 1969-04-23 1969-04-23

Publications (1)

Publication Number Publication Date
GB1265764A true GB1265764A (en) 1972-03-08

Family

ID=9032941

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1265764D Expired GB1265764A (en) 1969-04-23 1970-04-20

Country Status (5)

Country Link
BE (1) BE748749R (en)
DE (1) DE2019468A1 (en)
FR (1) FR2036958A6 (en)
GB (1) GB1265764A (en)
NL (1) NL7005954A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1538097A (en) * 1976-01-26 1979-01-10 Lafon Labor Substituted phenyl-amidines

Also Published As

Publication number Publication date
BE748749R (en) 1970-09-16
DE2019468A1 (en) 1971-02-18
NL7005954A (en) 1970-10-27
FR2036958A6 (en) 1970-12-31

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Legal Events

Date Code Title Description
PS Patent sealed
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PE20 Patent expired after termination of 20 years