GB1260521A - Phenethanolamine ethers - Google Patents
Phenethanolamine ethersInfo
- Publication number
- GB1260521A GB1260521A GB6379/69A GB637969A GB1260521A GB 1260521 A GB1260521 A GB 1260521A GB 6379/69 A GB6379/69 A GB 6379/69A GB 637969 A GB637969 A GB 637969A GB 1260521 A GB1260521 A GB 1260521A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl ester
- ester hydrochloride
- tert
- compounds
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Phenethanolamine ethers Chemical class 0.000 title 1
- 229950006768 phenylethanolamine Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- YFQZWJFXVOLGAW-UHFFFAOYSA-N Cl.COC(C=1C(=CC=C(C1)C(CN(C(CCC1=CC=CC=C1)(C)C)CC1=CC=CC=C1)=O)OC)=O Chemical compound Cl.COC(C=1C(=CC=C(C1)C(CN(C(CCC1=CC=CC=C1)(C)C)CC1=CC=CC=C1)=O)OC)=O YFQZWJFXVOLGAW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000674 adrenergic antagonist Substances 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 abstract 1
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- LAUMJRGNMQCAEM-UHFFFAOYSA-N methyl 5-[1-hydroxy-2-(propan-2-ylamino)ethyl]-2-phenylmethoxybenzoate hydrochloride Chemical compound Cl.COC(C1=C(C=CC(=C1)C(CNC(C)C)O)OCC1=CC=CC=C1)=O LAUMJRGNMQCAEM-UHFFFAOYSA-N 0.000 abstract 1
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6379/69A GB1260521A (en) | 1969-02-06 | 1969-02-06 | Phenethanolamine ethers |
| ZA700532A ZA70532B (en) | 1969-02-06 | 1970-01-26 | Phenethanolamine ethers |
| BE745138D BE745138A (fr) | 1969-02-06 | 1970-01-29 | Nouvelles phenylethanolamines |
| DE19702004354 DE2004354C3 (de) | 1969-02-06 | 1970-01-30 | Phenäthanolaminäther, Verfahren zu Ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| CH643273A CH561686A5 (enrdf_load_stackoverflow) | 1969-02-06 | 1970-02-05 | |
| FR7004092A FR2034524B1 (enrdf_load_stackoverflow) | 1969-02-06 | 1970-02-05 | |
| SE7001478A SE372933B (enrdf_load_stackoverflow) | 1969-02-06 | 1970-02-05 | |
| CH163470A CH555801A (de) | 1969-02-06 | 1970-02-05 | Verfahren zur herstellung von phenylaethanolamin-derivaten. |
| NLAANVRAGE7001759,A NL170134C (nl) | 1969-02-06 | 1970-02-06 | Werkwijze ter bereiding van een geneesmiddel met anti-adrenergische activiteit en daarmee verkregen gevormd geneesmiddel, alsmede werkwijze voor het bereiden van een anti-adrenergisch actieve 5-(1-hydroxy-2-aminoethyl)benzoezuuramide verbinding. |
| JP45010082A JPS5221B1 (enrdf_load_stackoverflow) | 1969-02-06 | 1970-02-06 | |
| US05/706,619 US4101579A (en) | 1969-02-06 | 1976-07-19 | Phenethanolamine ethers |
| JP8805276A JPS549189B1 (enrdf_load_stackoverflow) | 1969-02-06 | 1976-07-23 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6379/69A GB1260521A (en) | 1969-02-06 | 1969-02-06 | Phenethanolamine ethers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1260521A true GB1260521A (en) | 1972-01-19 |
Family
ID=9813435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6379/69A Expired GB1260521A (en) | 1969-02-06 | 1969-02-06 | Phenethanolamine ethers |
Country Status (8)
| Country | Link |
|---|---|
| JP (2) | JPS5221B1 (enrdf_load_stackoverflow) |
| BE (1) | BE745138A (enrdf_load_stackoverflow) |
| CH (2) | CH561686A5 (enrdf_load_stackoverflow) |
| FR (1) | FR2034524B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1260521A (enrdf_load_stackoverflow) |
| NL (1) | NL170134C (enrdf_load_stackoverflow) |
| SE (1) | SE372933B (enrdf_load_stackoverflow) |
| ZA (1) | ZA70532B (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000193A (en) | 1973-05-07 | 1976-12-28 | Allen & Hanburys Limited | Pharmacologically active compounds |
| US4000192A (en) | 1973-05-07 | 1976-12-28 | Allen & Hanburys Limited | Pharmacologically active compounds |
| DE3014775A1 (de) * | 1979-05-04 | 1980-11-13 | Richardson Merrell Inc | Neue antihypertensive verbindung |
| CN104513177A (zh) * | 2014-12-12 | 2015-04-15 | 上海应用技术学院 | 一种5-(n,n-二苄基氨基)乙酰水杨酰胺的制备方法 |
| CN104557604A (zh) * | 2014-12-30 | 2015-04-29 | 浙江大学 | 5-乙酰基水杨酰胺的合成方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5433100U (enrdf_load_stackoverflow) * | 1977-08-07 | 1979-03-03 | ||
| JPS5460498U (enrdf_load_stackoverflow) * | 1977-10-06 | 1979-04-26 |
-
1969
- 1969-02-06 GB GB6379/69A patent/GB1260521A/en not_active Expired
-
1970
- 1970-01-26 ZA ZA700532A patent/ZA70532B/xx unknown
- 1970-01-29 BE BE745138D patent/BE745138A/xx unknown
- 1970-02-05 CH CH643273A patent/CH561686A5/xx not_active IP Right Cessation
- 1970-02-05 SE SE7001478A patent/SE372933B/xx unknown
- 1970-02-05 FR FR7004092A patent/FR2034524B1/fr not_active Expired
- 1970-02-05 CH CH163470A patent/CH555801A/xx not_active IP Right Cessation
- 1970-02-06 NL NLAANVRAGE7001759,A patent/NL170134C/xx not_active IP Right Cessation
- 1970-02-06 JP JP45010082A patent/JPS5221B1/ja active Pending
-
1976
- 1976-07-23 JP JP8805276A patent/JPS549189B1/ja active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4000193A (en) | 1973-05-07 | 1976-12-28 | Allen & Hanburys Limited | Pharmacologically active compounds |
| US4000192A (en) | 1973-05-07 | 1976-12-28 | Allen & Hanburys Limited | Pharmacologically active compounds |
| DE3014775A1 (de) * | 1979-05-04 | 1980-11-13 | Richardson Merrell Inc | Neue antihypertensive verbindung |
| CN104513177A (zh) * | 2014-12-12 | 2015-04-15 | 上海应用技术学院 | 一种5-(n,n-二苄基氨基)乙酰水杨酰胺的制备方法 |
| CN104513177B (zh) * | 2014-12-12 | 2017-01-04 | 上海应用技术学院 | 一种5-(n,n-二苄基氨基)乙酰水杨酰胺的制备方法 |
| CN104557604A (zh) * | 2014-12-30 | 2015-04-29 | 浙江大学 | 5-乙酰基水杨酰胺的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| NL170134B (nl) | 1982-05-03 |
| ZA70532B (en) | 1971-03-31 |
| NL170134C (nl) | 1982-10-01 |
| DE2004354B2 (de) | 1975-10-30 |
| JPS5221B1 (enrdf_load_stackoverflow) | 1977-01-05 |
| SE372933B (enrdf_load_stackoverflow) | 1975-01-20 |
| JPS549189B1 (enrdf_load_stackoverflow) | 1979-04-21 |
| CH555801A (de) | 1974-11-15 |
| BE745138A (fr) | 1970-07-29 |
| CH561686A5 (enrdf_load_stackoverflow) | 1975-05-15 |
| FR2034524A1 (enrdf_load_stackoverflow) | 1970-12-11 |
| FR2034524B1 (enrdf_load_stackoverflow) | 1973-12-21 |
| DE2004354A1 (enrdf_load_stackoverflow) | 1970-12-23 |
| NL7001759A (enrdf_load_stackoverflow) | 1970-08-10 |
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