GB1260016A - IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONS - Google Patents
IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONSInfo
- Publication number
- GB1260016A GB1260016A GB34927/69A GB3492769A GB1260016A GB 1260016 A GB1260016 A GB 1260016A GB 34927/69 A GB34927/69 A GB 34927/69A GB 3492769 A GB3492769 A GB 3492769A GB 1260016 A GB1260016 A GB 1260016A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- halophenoxy
- bis
- reaction
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,260,016. Compounds containing a plurality of bis - (p - halophenoxy)acetoxy functions. SANDOZ Ltd. 11 July, 1969 [29 July, 1968; 22 Oct., 1968; 5 Aug., 1968], No. 34927/69. Heading C2C. Novel compounds containing a plurality of bis-(p-halophenoxy)acetoxy functions of the general formula wherein n is a whole number of from 2 to 6, X 1 and X 2 , which are the same, are each a chlorine or bromine atom, A is either a saturated C 2-6 aliphatic hydrocarbon moiety having 2-6 units of valency, the number of units of valency of A being equal to n, and no carbon atom having more than one unit of valency; or, when n is 2, A is (i) a divalent group of the formula in which X<SP>1</SP> 1 and X<SP>1</SP> 2 , which are the same, are each a chlorine or bromine atom, or (ii) a divalent group of the formula are prepared (a) by reaction of a bis-(p-halophenoxy)-acetic acid or derivative thereof of the general formula wherein Y is a chlorine, bromine or iodine atom, a hydroxy group or a group of the formula with an alcohol or derivative thereof of the general formula A-(OM)n, wherein M is a hydrogen or alkali metal atom, with the proviso that when Y is a hydroxy group, M is a hydrogen atom, or (b) by reaction of an alcohol of the general formula A-(OH) n with a bis-(p-halophenoxy)-acetic acid ester or malonic acid ester of the general formula wherein Z 1 is a R-O-CO- group, in which R is a C 1-6 alkyl group, and Z 2 is as Z 1 or a hydrogen atom, with the proviso that when Z 2 is as Z 1 , the reaction is carried out at a temperature sufficiently high for partial decarboxylation to occur. Alcohols or derivatives thereof of the fourth general formula above wherein A is (i) above are prepared by reduction of a bis-(p-halophenoxy)-malonic acid ester of the fifth general formula above. Bis - (p - halophenoxy) - acetic acid esters or malonic acid esters of the fifth general formula above are prepared by reaction of a p-halophenol of the general formula with a dihalo-acetic acid ester or malonic acid ester of the general formula (X 1 ) 2 CZ 1 Z 2 , the p-halophenol being in the form of an alkali metal phenolate or the reaction being carried out in the presence of an acid-binding agent. Pharmaceutical compositions having hypocholesteremic/hypolipemic activity comprise, as active ingredient, a compound containing a plurality of bis-(p-halophenoxy)acetoxy functions of the first general formula above, in combination with a pharmaceutically acceptable diluent or carrier, and may be administered orally.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74823468A | 1968-07-29 | 1968-07-29 | |
| US75000468A | 1968-08-05 | 1968-08-05 | |
| US769725A US3542795A (en) | 1968-10-22 | 1968-10-22 | Di-bis(p-chlorophenoxy) acetic acid esters of dimethylol pyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1260016A true GB1260016A (en) | 1972-01-12 |
Family
ID=27419362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB34927/69A Expired GB1260016A (en) | 1968-07-29 | 1969-07-11 | IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONS |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE736676A (en) |
| CH (2) | CH511208A (en) |
| DE (1) | DE1937899A1 (en) |
| ES (1) | ES369926A1 (en) |
| FR (1) | FR2013914A1 (en) |
| GB (1) | GB1260016A (en) |
| IL (1) | IL32711A (en) |
| NL (1) | NL6911555A (en) |
-
1969
- 1969-07-07 CH CH827871A patent/CH511208A/en not_active IP Right Cessation
- 1969-07-07 CH CH1039969A patent/CH510615A/en not_active IP Right Cessation
- 1969-07-11 GB GB34927/69A patent/GB1260016A/en not_active Expired
- 1969-07-25 DE DE19691937899 patent/DE1937899A1/en active Pending
- 1969-07-26 ES ES369926A patent/ES369926A1/en not_active Expired
- 1969-07-27 IL IL32711A patent/IL32711A/en unknown
- 1969-07-28 BE BE736676A patent/BE736676A/xx unknown
- 1969-07-28 FR FR6925723A patent/FR2013914A1/fr not_active Withdrawn
- 1969-07-29 NL NL6911555A patent/NL6911555A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH510615A (en) | 1971-07-31 |
| IL32711A0 (en) | 1969-09-25 |
| DE1937899A1 (en) | 1970-01-29 |
| NL6911555A (en) | 1970-02-02 |
| BE736676A (en) | 1970-01-28 |
| FR2013914A1 (en) | 1970-04-10 |
| IL32711A (en) | 1972-05-30 |
| CH511208A (en) | 1971-08-15 |
| ES369926A1 (en) | 1972-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |