ES369926A1 - IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONS - Google Patents

IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONS

Info

Publication number
ES369926A1
ES369926A1 ES369926A ES369926A ES369926A1 ES 369926 A1 ES369926 A1 ES 369926A1 ES 369926 A ES369926 A ES 369926A ES 369926 A ES369926 A ES 369926A ES 369926 A1 ES369926 A1 ES 369926A1
Authority
ES
Spain
Prior art keywords
general formula
halophenoxy
bis
reaction
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES369926A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US769725A external-priority patent/US3542795A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES369926A1 publication Critical patent/ES369926A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds containing a plurality of bis-(p-halophenoxy)acetoxy functions of the general formula wherein n is a whole number of from 2 to 6, X 1 and X 2 , which are the same, are each a chlorine or bromine atom, A is either a saturated C 2-6 aliphatic hydrocarbon moiety having 2-6 units of valency, the number of units of valency of A being equal to n, and no carbon atom having more than one unit of valency or, when n is 2, A is (i) a divalent group of the formula in which X1 1 and X1 2 , which are the same, are each a chlorine or bromine atom, or (ii) a divalent group of the formula are prepared (a) by reaction of a bis-(p-halophenoxy)-acetic acid or derivative thereof of the general formula wherein Y is a chlorine, bromine or iodine atom, a hydroxy group or a group of the formula with an alcohol or derivative thereof of the general formula A-(OM)n, wherein M is a hydrogen or alkali metal atom, with the proviso that when Y is a hydroxy group, M is a hydrogen atom, or (b) by reaction of an alcohol of the general formula A-(OH) n with a bis-(p-halophenoxy)-acetic acid ester or malonic acid ester of the general formula wherein Z 1 is a R-O-CO- group, in which R is a C 1-6 alkyl group, and Z 2 is as Z 1 or a hydrogen atom, with the proviso that when Z 2 is as Z 1 , the reaction is carried out at a temperature sufficiently high for partial decarboxylation to occur. Alcohols or derivatives thereof of the fourth general formula above wherein A is (i) above are prepared by reduction of a bis-(p-halophenoxy)-malonic acid ester of the fifth general formula above. Bis - (p - halophenoxy) - acetic acid esters or malonic acid esters of the fifth general formula above are prepared by reaction of a p-halophenol of the general formula with a dihalo-acetic acid ester or malonic acid ester of the general formula (X 1 ) 2 CZ 1 Z 2 , the p-halophenol being in the form of an alkali metal phenolate or the reaction being carried out in the presence of an acid-binding agent. Pharmaceutical compositions having hypocholesteremic/hypolipemic activity comprise, as active ingredient, a compound containing a plurality of bis-(p-halophenoxy)acetoxy functions of the first general formula above, in combination with a pharmaceutically acceptable diluent or carrier, and may be administered orally.
ES369926A 1968-07-29 1969-07-26 IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONS Expired ES369926A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74823468A 1968-07-29 1968-07-29
US75000468A 1968-08-05 1968-08-05
US769725A US3542795A (en) 1968-10-22 1968-10-22 Di-bis(p-chlorophenoxy) acetic acid esters of dimethylol pyridines

Publications (1)

Publication Number Publication Date
ES369926A1 true ES369926A1 (en) 1972-01-01

Family

ID=27419362

Family Applications (1)

Application Number Title Priority Date Filing Date
ES369926A Expired ES369926A1 (en) 1968-07-29 1969-07-26 IMPROVEMENTS IN OR RELATING TO COMPOUNDS CONTAINING A PLURALITY OF BIS-(p-HALOPHENOXY) ACETOXY FUNCTIONS

Country Status (8)

Country Link
BE (1) BE736676A (en)
CH (2) CH511208A (en)
DE (1) DE1937899A1 (en)
ES (1) ES369926A1 (en)
FR (1) FR2013914A1 (en)
GB (1) GB1260016A (en)
IL (1) IL32711A (en)
NL (1) NL6911555A (en)

Also Published As

Publication number Publication date
DE1937899A1 (en) 1970-01-29
IL32711A0 (en) 1969-09-25
IL32711A (en) 1972-05-30
CH511208A (en) 1971-08-15
BE736676A (en) 1970-01-28
GB1260016A (en) 1972-01-12
NL6911555A (en) 1970-02-02
FR2013914A1 (en) 1970-04-10
CH510615A (en) 1971-07-31

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