GB1257162A - - Google Patents
Info
- Publication number
- GB1257162A GB1257162A GB1257162DA GB1257162A GB 1257162 A GB1257162 A GB 1257162A GB 1257162D A GB1257162D A GB 1257162DA GB 1257162 A GB1257162 A GB 1257162A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- chain
- group
- substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 238000006114 decarboxylation reaction Methods 0.000 abstract 2
- 238000006193 diazotization reaction Methods 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- MADXBPNZEUKBMC-UHFFFAOYSA-N 1-[2-[3-(2-acetyl-3-hydroxy-6-iodophenoxy)-2-hydroxypropoxy]-6-hydroxy-3-iodophenyl]ethanone Chemical compound C(C)(=O)C1=C(OCC(COC2=C(C(=CC=C2I)O)C(C)=O)O)C(=CC=C1O)I MADXBPNZEUKBMC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- NUFXIYCFLOCXDI-UHFFFAOYSA-N 4-[5-(4-carboxy-3-hydroxyphenoxy)pentoxy]-2-hydroxybenzoic acid Chemical compound C(=O)(O)C1=C(C=C(OCCCCCOC2=CC(=C(C=C2)C(=O)O)O)C=C1)O NUFXIYCFLOCXDI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- GXIJVAHGKBARGD-UHFFFAOYSA-N ethyl 5-[3-(2-ethoxycarbonyl-6-iodo-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-6-iodo-4-oxochromene-2-carboxylate Chemical compound C(C)OC(=O)C=1OC2=CC=C(C(=C2C(C1)=O)OCC(COC1=C2C(C=C(OC2=CC=C1I)C(=O)OCC)=O)O)I GXIJVAHGKBARGD-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- IHGHGLWUTZWQKI-UHFFFAOYSA-N methyl 2-hydroxy-4-[5-(3-hydroxy-4-methoxycarbonylphenoxy)pentoxy]benzoate Chemical compound OC=1C=C(OCCCCCOC2=CC(=C(C=C2)C(=O)OC)O)C=CC1C(=O)OC IHGHGLWUTZWQKI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB758768 | 1968-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1257162A true GB1257162A (enrdf_load_stackoverflow) | 1971-12-15 |
Family
ID=9835993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1257162D Expired GB1257162A (enrdf_load_stackoverflow) | 1968-02-16 | 1968-02-16 |
Country Status (2)
| Country | Link |
|---|---|
| AT (1) | AT305981B (enrdf_load_stackoverflow) |
| GB (1) | GB1257162A (enrdf_load_stackoverflow) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102341391A (zh) * | 2009-01-29 | 2012-02-01 | 通用医疗公司 | 色甘酸衍生物以及成像和治疗的相关方法 |
| US9855276B2 (en) | 2012-10-25 | 2018-01-02 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10188757B2 (en) | 2013-10-22 | 2019-01-29 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US10561612B2 (en) | 2017-07-20 | 2020-02-18 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and ibuprofen |
| US11291648B2 (en) | 2018-07-02 | 2022-04-05 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and alpha-lactose |
| US11679095B2 (en) | 2016-08-31 | 2023-06-20 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| US12383528B2 (en) | 2018-12-10 | 2025-08-12 | The General Hospital Corporation | Cromolyn esters and uses thereof |
-
1968
- 1968-02-16 GB GB1257162D patent/GB1257162A/en not_active Expired
-
1969
- 1969-02-11 AT AT514471A patent/AT305981B/de active
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10576171B2 (en) | 2009-01-29 | 2020-03-03 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US11801316B2 (en) | 2009-01-29 | 2023-10-31 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US8617517B2 (en) | 2009-01-29 | 2013-12-31 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| AU2010208136B2 (en) * | 2009-01-29 | 2015-03-05 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CN102341391B (zh) * | 2009-01-29 | 2015-08-19 | 通用医疗公司 | 色甘酸衍生物以及制备成像和治疗的药物中的应用 |
| CN105061376A (zh) * | 2009-01-29 | 2015-11-18 | 通用医疗公司 | 色甘酸衍生物以及成像和治疗的相关方法 |
| CN102341391A (zh) * | 2009-01-29 | 2012-02-01 | 通用医疗公司 | 色甘酸衍生物以及成像和治疗的相关方法 |
| EP3567033A1 (en) * | 2009-01-29 | 2019-11-13 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US10251961B2 (en) | 2009-01-29 | 2019-04-09 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| EP2391618A4 (en) * | 2009-01-29 | 2012-07-18 | Gen Hospital Corp | CROMOLE DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATING |
| US10245331B2 (en) | 2009-01-29 | 2019-04-02 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US9855276B2 (en) | 2012-10-25 | 2018-01-02 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US9968618B1 (en) | 2012-10-25 | 2018-05-15 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10406164B2 (en) | 2012-10-25 | 2019-09-10 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US9918992B2 (en) | 2012-10-25 | 2018-03-20 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US10413551B2 (en) | 2012-10-25 | 2019-09-17 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer'S disease and related disorders |
| US9913847B2 (en) | 2012-10-25 | 2018-03-13 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
| US10398704B2 (en) | 2012-10-25 | 2019-09-03 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| US11110097B2 (en) | 2012-10-25 | 2021-09-07 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US11013686B2 (en) | 2013-05-23 | 2021-05-25 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| US11666669B2 (en) | 2013-10-22 | 2023-06-06 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US10188757B2 (en) | 2013-10-22 | 2019-01-29 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| US11679095B2 (en) | 2016-08-31 | 2023-06-20 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| US10561612B2 (en) | 2017-07-20 | 2020-02-18 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and ibuprofen |
| US11291648B2 (en) | 2018-07-02 | 2022-04-05 | The General Hospital Corporation | Powdered formulations of cromolyn sodium and alpha-lactose |
| US12383528B2 (en) | 2018-12-10 | 2025-08-12 | The General Hospital Corporation | Cromolyn esters and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AT305981B (de) | 1973-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |