GB1256914A - - Google Patents
Info
- Publication number
- GB1256914A GB1256914A GB1256914DA GB1256914A GB 1256914 A GB1256914 A GB 1256914A GB 1256914D A GB1256914D A GB 1256914DA GB 1256914 A GB1256914 A GB 1256914A
- Authority
- GB
- United Kingdom
- Prior art keywords
- extract
- iboga
- alkaloid
- jan
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000284 extract Substances 0.000 abstract 6
- 241001246918 Tabernanthe iboga Species 0.000 abstract 4
- 229930013930 alkaloid Natural products 0.000 abstract 3
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- VOXIUXZAOFEFBL-UHFFFAOYSA-N Voacangin Natural products CCC1CC2CN3CC1C(C2)(OC(=O)C)c4[nH]c5ccc(OC)cc5c4C3 VOXIUXZAOFEFBL-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229940025084 amphetamine Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000005520 cutting process Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229930182478 glucoside Natural products 0.000 abstract 1
- 150000008131 glucosides Chemical class 0.000 abstract 1
- HSIBGVUMFOSJPD-CFDPKNGZSA-N ibogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(OC)C=C12 HSIBGVUMFOSJPD-CFDPKNGZSA-N 0.000 abstract 1
- OLOCMRXSJQJJPL-UHFFFAOYSA-N ibogaine Natural products CCC1CC2CC3C1N(C2)C=Cc4c3[nH]c5ccc(OC)cc45 OLOCMRXSJQJJPL-UHFFFAOYSA-N 0.000 abstract 1
- AREITJMUSRHSBK-UHFFFAOYSA-N ibogamine Natural products CCC1CC2C3CC1CN2CCc4c3[nH]c5ccccc45 AREITJMUSRHSBK-UHFFFAOYSA-N 0.000 abstract 1
- 238000001671 psychotherapy Methods 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR138081A FR7131M (fr) | 1968-01-31 | 1968-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1256914A true GB1256914A (fr) | 1971-12-15 |
Family
ID=8645336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1256914D Expired GB1256914A (fr) | 1968-01-31 | 1969-01-30 |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE726760A (fr) |
| CA (1) | CA939266A (fr) |
| DE (1) | DE1902227A1 (fr) |
| FR (1) | FR7131M (fr) |
| GB (1) | GB1256914A (fr) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0261977A2 (fr) * | 1986-09-26 | 1988-03-30 | MITSUI TOATSU CHEMICALS, Inc. | Dérivés du catéchol et préparations préventives et médicinales pour le traitement de troubles régressifs dans le système nerveux central |
| EP0511325A1 (fr) * | 1990-05-31 | 1992-11-04 | Nda International, Inc. | Procede rapide d'interruption ou d'attenuation des syndromes de dependance polydrogues |
| US5214034A (en) * | 1986-09-26 | 1993-05-25 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same |
| US5290793A (en) * | 1989-09-12 | 1994-03-01 | Mitsui Toatsu Chemicals, Incorporated | Dihydrocaffeic acid derivatives and pharmaceutical preparation containing same |
| EP1383465A2 (fr) * | 2001-03-29 | 2004-01-28 | Emory University | Augmentation accrue de la psychotherapie par voie pharmacologique, avec un activateur d'apprentissage ou de conditionnement |
| US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| US7754710B2 (en) | 1997-09-04 | 2010-07-13 | Novoneuron, Inc. | Noribogaine in the treatment of pain and drug addiction |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8859764B2 (en) | 2011-01-26 | 2014-10-14 | Demerx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US8877921B2 (en) | 2012-01-25 | 2014-11-04 | Demerx, Inc. | Synthetic voacangine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US9051343B2 (en) | 2011-12-09 | 2015-06-09 | Demerx, Inc. | Phosphate esters of noribogaine |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| US9358237B2 (en) | 2010-07-23 | 2016-06-07 | Demerx, Inc. | Noribogaine compositions |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857523A (en) * | 1988-07-18 | 1989-08-15 | Nda International, Inc. | Rapid method for attenuating the alcohol dependency syndrome |
| US9561233B2 (en) | 2014-03-13 | 2017-02-07 | Demerx, Inc. | Use of ibogaine for the treatment of pain |
| US9592239B2 (en) | 2014-09-12 | 2017-03-14 | Demerx, Inc. | Methods and compositions for ibogaine treatment of impulse control disorder, anxiety-related disorders, violence and/or anger, or regulating food intake |
-
1968
- 1968-01-31 FR FR138081A patent/FR7131M/fr not_active Expired
-
1969
- 1969-01-10 BE BE726760D patent/BE726760A/xx unknown
- 1969-01-17 DE DE19691902227 patent/DE1902227A1/de active Pending
- 1969-01-29 CA CA41495A patent/CA939266A/en not_active Expired
- 1969-01-30 GB GB1256914D patent/GB1256914A/en not_active Expired
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0261977A2 (fr) * | 1986-09-26 | 1988-03-30 | MITSUI TOATSU CHEMICALS, Inc. | Dérivés du catéchol et préparations préventives et médicinales pour le traitement de troubles régressifs dans le système nerveux central |
| EP0261977A3 (en) * | 1986-09-26 | 1989-04-05 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system |
| US5214034A (en) * | 1986-09-26 | 1993-05-25 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same |
| US5290793A (en) * | 1989-09-12 | 1994-03-01 | Mitsui Toatsu Chemicals, Incorporated | Dihydrocaffeic acid derivatives and pharmaceutical preparation containing same |
| EP0511325A1 (fr) * | 1990-05-31 | 1992-11-04 | Nda International, Inc. | Procede rapide d'interruption ou d'attenuation des syndromes de dependance polydrogues |
| EP0511325A4 (en) * | 1990-05-31 | 1993-02-03 | Nda International, Inc. | A rapid method for interrupting or attenuating poly-drug dependency syndromes |
| US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| US7754710B2 (en) | 1997-09-04 | 2010-07-13 | Novoneuron, Inc. | Noribogaine in the treatment of pain and drug addiction |
| US8178524B2 (en) | 1997-09-04 | 2012-05-15 | Demerx, Inc. | Noribogaine in the treatment of pain and drug addiction |
| EP1383465A2 (fr) * | 2001-03-29 | 2004-01-28 | Emory University | Augmentation accrue de la psychotherapie par voie pharmacologique, avec un activateur d'apprentissage ou de conditionnement |
| EP1383465A4 (fr) * | 2001-03-29 | 2009-04-15 | Univ Emory | Augmentation accrue de la psychotherapie par voie pharmacologique, avec un activateur d'apprentissage ou de conditionnement |
| US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9308272B2 (en) | 2010-06-22 | 2016-04-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US9358237B2 (en) | 2010-07-23 | 2016-06-07 | Demerx, Inc. | Noribogaine compositions |
| US8859764B2 (en) | 2011-01-26 | 2014-10-14 | Demerx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9403817B2 (en) | 2011-01-26 | 2016-08-02 | Demerx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| US9051343B2 (en) | 2011-12-09 | 2015-06-09 | Demerx, Inc. | Phosphate esters of noribogaine |
| US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
| US9469649B2 (en) | 2012-01-25 | 2016-10-18 | Demerx, Inc. | Synthetic voacangine |
| US8877921B2 (en) | 2012-01-25 | 2014-11-04 | Demerx, Inc. | Synthetic voacangine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
Also Published As
| Publication number | Publication date |
|---|---|
| CA939266A (en) | 1974-01-01 |
| BE726760A (fr) | 1969-06-16 |
| FR7131M (fr) | 1969-07-21 |
| DE1902227A1 (de) | 1969-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |