GB1251035A - - Google Patents
Info
- Publication number
- GB1251035A GB1251035A GB1251035DA GB1251035A GB 1251035 A GB1251035 A GB 1251035A GB 1251035D A GB1251035D A GB 1251035DA GB 1251035 A GB1251035 A GB 1251035A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- penicillin
- alkyl
- hydrazide
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 abstract 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 5
- 229940049954 penicillin Drugs 0.000 abstract 5
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 4
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 108010073038 Penicillin Amidase Proteins 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- -1 naphthylacetic. Chemical compound 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MWIXENPCUPDSOS-QMMMGPOBSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanehydrazide Chemical compound NNC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWIXENPCUPDSOS-QMMMGPOBSA-N 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000123650 Botrytis cinerea Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- 241000588915 Klebsiella aerogenes Species 0.000 abstract 1
- 241001443590 Naganishia albida Species 0.000 abstract 1
- 241000228150 Penicillium chrysogenum Species 0.000 abstract 1
- 241000588769 Proteus <enterobacteria> Species 0.000 abstract 1
- 241000187389 Streptomyces lavendulae Species 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- FCCCRBDJBTVFSJ-UHFFFAOYSA-N butanehydrazide Chemical compound CCCC(=O)NN FCCCRBDJBTVFSJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- IXEIBWLTZYOBPF-UHFFFAOYSA-N cyclopentanecarbohydrazide Chemical compound NNC(=O)C1CCCC1 IXEIBWLTZYOBPF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- KMAKOBLIOCQGJP-UHFFFAOYSA-N indole-3-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=CNC2=C1 KMAKOBLIOCQGJP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/42—Compounds with a free primary amino radical attached in position 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/899—Streptomyces lavendulae
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67955767A | 1967-10-31 | 1967-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1251035A true GB1251035A (enExample) | 1971-10-27 |
Family
ID=24727400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1251035D Expired GB1251035A (enExample) | 1967-10-31 | 1968-10-28 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3616223A (enExample) |
| AT (1) | AT282062B (enExample) |
| BE (1) | BE723162A (enExample) |
| BR (1) | BR6803595D0 (enExample) |
| CH (1) | CH513919A (enExample) |
| CS (1) | CS153482B2 (enExample) |
| DE (1) | DE1805571A1 (enExample) |
| DK (1) | DK129719B (enExample) |
| ES (1) | ES359709A1 (enExample) |
| FI (1) | FI46628C (enExample) |
| FR (1) | FR1604167A (enExample) |
| GB (1) | GB1251035A (enExample) |
| IE (1) | IE32526B1 (enExample) |
| IL (1) | IL30870A (enExample) |
| NL (1) | NL140567B (enExample) |
| NO (1) | NO134912C (enExample) |
| SE (1) | SE357202B (enExample) |
| SU (1) | SU409427A3 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5510238B2 (enExample) * | 1973-05-30 | 1980-03-14 |
-
1967
- 1967-10-31 US US679557A patent/US3616223A/en not_active Expired - Lifetime
-
1968
- 1968-10-13 IL IL30870A patent/IL30870A/en unknown
- 1968-10-18 DK DK501968AA patent/DK129719B/da unknown
- 1968-10-21 IE IE1259/68A patent/IE32526B1/xx unknown
- 1968-10-22 SE SE14284/68A patent/SE357202B/xx unknown
- 1968-10-24 NO NO4218/68A patent/NO134912C/no unknown
- 1968-10-28 GB GB1251035D patent/GB1251035A/en not_active Expired
- 1968-10-28 DE DE19681805571 patent/DE1805571A1/de active Pending
- 1968-10-29 ES ES359709A patent/ES359709A1/es not_active Expired
- 1968-10-29 FI FI683078A patent/FI46628C/fi active
- 1968-10-30 SU SU1279808A patent/SU409427A3/ru active
- 1968-10-30 NL NL686815466A patent/NL140567B/xx unknown
- 1968-10-30 BR BR203595/68A patent/BR6803595D0/pt unknown
- 1968-10-30 BE BE723162D patent/BE723162A/xx unknown
- 1968-10-31 FR FR1604167D patent/FR1604167A/fr not_active Expired
- 1968-10-31 CS CS743768A patent/CS153482B2/cs unknown
- 1968-10-31 AT AT1064968A patent/AT282062B/de not_active IP Right Cessation
- 1968-10-31 CH CH1627968A patent/CH513919A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE32526B1 (en) | 1973-09-05 |
| IL30870A (en) | 1972-06-28 |
| NO134912C (enExample) | 1977-01-05 |
| NL140567B (nl) | 1973-12-17 |
| SE357202B (enExample) | 1973-06-18 |
| CH513919A (de) | 1971-10-15 |
| AT282062B (de) | 1970-06-10 |
| SU409427A3 (enExample) | 1973-11-30 |
| ES359709A1 (es) | 1970-09-16 |
| IE32526L (en) | 1969-04-30 |
| DK129719B (da) | 1974-11-11 |
| US3616223A (en) | 1971-10-26 |
| FR1604167A (enExample) | 1971-07-26 |
| BR6803595D0 (pt) | 1973-02-22 |
| BE723162A (enExample) | 1969-04-30 |
| DK129719C (enExample) | 1975-04-21 |
| FI46628B (enExample) | 1973-01-31 |
| CS153482B2 (enExample) | 1974-02-25 |
| IL30870A0 (en) | 1968-12-26 |
| NL6815466A (enExample) | 1969-05-02 |
| DE1805571A1 (de) | 1970-05-14 |
| FI46628C (fi) | 1973-05-08 |
| NO134912B (enExample) | 1976-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |