GB1213492A - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- GB1213492A GB1213492A GB1155168A GB1155168A GB1213492A GB 1213492 A GB1213492 A GB 1213492A GB 1155168 A GB1155168 A GB 1155168A GB 1155168 A GB1155168 A GB 1155168A GB 1213492 A GB1213492 A GB 1213492A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- substituted
- acid
- medium
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1,213,492. Penicillins. ANKERFARM S.p.A. 8 March, 1968 [8 March, 1967], No. 11551/68. Heading C2A. Semi-synthetic penicillins are prepared by subjecting a penicillin to the action of a penicillin acylase in an alkaline medium whereby the penicillin is enzymatically hydrolysed to 6-APA, adjusting the pH of the medium to an acid pH and reacting the 6-APA formed with an appropriate amide or ester of a carboxylic acid in the resulting acidic medium and in the presence of said penicillin acylase to produce the desired semi-synthetic penicillin (other than the starting penicillin), said carboxylic amide being unsubstituted at the nitrogen atom of the amide group. The alkaline medium has a pH of 7À5 to 8À0 and the acid medium a pH of 3 to 6À9. The hydrolysis of benzylpenicillin or phenoxymethylpenicillin is preferably by means of a penicillin acylase of E. Coli Ankerfarm Sp. 24/14 (C.B.S. 12.8.67) which is resistant to high concentrations of phenylacetic acid and phenoxyacetic acid. The amide or ester may have the formula wherein R 1 may be H, alkyl, aryl, aralkyl, heterocyclic which may be substituted; R 2 is NH 2 or OR 3 wherein R 3 is alkyl, aryl, aralkyl or heterocyclic which may be substituted. R 1 may also be wherein R 4 is H, alkyl, aryl, aralkyl or heterocyclic which may be substituted in at least one position and R 5 is NH 2 which may be substituted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1345367 | 1967-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1213492A true GB1213492A (en) | 1970-11-25 |
Family
ID=11144456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1155168A Expired GB1213492A (en) | 1967-03-08 | 1968-03-08 | Penicillins |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE720791A (en) |
| DE (1) | DE1670033A1 (en) |
| DK (1) | DK132631C (en) |
| FR (1) | FR1574713A (en) |
| GB (1) | GB1213492A (en) |
| NL (1) | NL6705788A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5011475B1 (en) * | 1969-10-16 | 1975-05-01 |
-
1967
- 1967-04-25 NL NL6705788A patent/NL6705788A/xx unknown
-
1968
- 1968-02-08 FR FR1574713D patent/FR1574713A/fr not_active Expired
- 1968-03-02 DE DE19681670033 patent/DE1670033A1/en active Pending
- 1968-03-07 DK DK95368A patent/DK132631C/en active
- 1968-03-08 GB GB1155168A patent/GB1213492A/en not_active Expired
- 1968-09-13 BE BE720791D patent/BE720791A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1670033A1 (en) | 1971-02-25 |
| BE720791A (en) | 1969-02-17 |
| NL6705788A (en) | 1968-09-09 |
| DK132631C (en) | 1976-06-08 |
| DK132631B (en) | 1976-01-12 |
| FR1574713A (en) | 1969-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 414F | Notice of opposition given (sect. 14/1949) | ||
| 414C | Case decided by the comptroller ** grants refused (sect. 14/1949) | ||
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |