GB1248324A - Pyridoxine alpha-ketoglutarate and derivatives thereof - Google Patents
Pyridoxine alpha-ketoglutarate and derivatives thereofInfo
- Publication number
- GB1248324A GB1248324A GB55925/69A GB5592569A GB1248324A GB 1248324 A GB1248324 A GB 1248324A GB 55925/69 A GB55925/69 A GB 55925/69A GB 5592569 A GB5592569 A GB 5592569A GB 1248324 A GB1248324 A GB 1248324A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pyridoxine
- derivatives
- ketoglutarate
- formula
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MLAUVUHGQARGDU-UHFFFAOYSA-N 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;2-oxopentanedioic acid Chemical compound OC(=O)CCC(=O)C(O)=O.CC1=NC=C(CO)C(CO)=C1O MLAUVUHGQARGDU-UHFFFAOYSA-N 0.000 title abstract 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 1
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 abstract 1
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000003049 inorganic solvent Substances 0.000 abstract 1
- 229910001867 inorganic solvent Inorganic materials 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- -1 organic base cation Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000008160 pyridoxine Nutrition 0.000 abstract 1
- 239000011677 pyridoxine Substances 0.000 abstract 1
- 150000003227 pyridoxines Chemical class 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES360566A ES360566A1 (es) | 1968-11-22 | 1968-11-22 | Un metodo de obtencion de alfa-cetoglutarato de piridoxina y sus derivados. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1248324A true GB1248324A (en) | 1971-09-29 |
Family
ID=8451045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55925/69A Expired GB1248324A (en) | 1968-11-22 | 1969-11-14 | Pyridoxine alpha-ketoglutarate and derivatives thereof |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE742026A (enrdf_load_stackoverflow) |
| CH (1) | CH529134A (enrdf_load_stackoverflow) |
| DE (1) | DE1958226C3 (enrdf_load_stackoverflow) |
| DK (1) | DK133465B (enrdf_load_stackoverflow) |
| ES (1) | ES360566A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2023937B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1248324A (enrdf_load_stackoverflow) |
| SE (1) | SE368571B (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459468B2 (en) | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| US7812037B2 (en) | 2004-10-28 | 2010-10-12 | Medicure International, Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1141070B (it) * | 1980-09-22 | 1986-10-01 | Luso Farmaco Inst | Impiego dell'alfa-chetoglutarato di piridossina nella profilassi della iperlattacidemia |
| FR2531713A2 (fr) * | 1981-09-16 | 1984-02-17 | Panmedica Sa | Nouvelles compositions a base de 5-hydroxytryptophane, leur procede de preparation et medicaments les contenant |
| DE4326763A1 (de) * | 1993-08-10 | 1995-02-16 | Kirsten Schadow | Wagen |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| JP2002539127A (ja) | 1999-03-08 | 2002-11-19 | メディキュア インコーポレーテッド | ビタミンｂ−６障害のためのピリドキサル類縁体 |
| US6489345B1 (en) | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
| EP1872797A3 (en) | 1999-08-24 | 2008-04-02 | Medicure International Inc. | Treatment of cardiovascular and related pathologies |
| ES2240419T3 (es) | 2000-02-29 | 2005-10-16 | Medicure International Inc. | Fosfonatos protectores del corazon. |
| AU784840B2 (en) | 2000-03-28 | 2006-07-06 | Medicure International Inc. | Treatment of cerebrovascular disease |
| US6897228B2 (en) | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| WO2002004421A2 (en) | 2000-07-07 | 2002-01-17 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
-
1968
- 1968-11-22 ES ES360566A patent/ES360566A1/es not_active Expired
-
1969
- 1969-11-14 GB GB55925/69A patent/GB1248324A/en not_active Expired
- 1969-11-18 SE SE15841/69A patent/SE368571B/xx unknown
- 1969-11-19 DK DK612469AA patent/DK133465B/da not_active IP Right Cessation
- 1969-11-20 CH CH1730969A patent/CH529134A/de not_active IP Right Cessation
- 1969-11-20 DE DE1958226A patent/DE1958226C3/de not_active Expired
- 1969-11-21 FR FR696940244A patent/FR2023937B1/fr not_active Expired
- 1969-11-21 BE BE742026D patent/BE742026A/xx not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459468B2 (en) | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| US7812037B2 (en) | 2004-10-28 | 2010-10-12 | Medicure International, Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| DK133465C (enrdf_load_stackoverflow) | 1976-11-22 |
| ES360566A1 (es) | 1970-10-16 |
| DE1958226B2 (de) | 1973-07-26 |
| BE742026A (enrdf_load_stackoverflow) | 1970-05-21 |
| FR2023937B1 (enrdf_load_stackoverflow) | 1973-04-06 |
| FR2023937A1 (enrdf_load_stackoverflow) | 1970-08-21 |
| SE368571B (enrdf_load_stackoverflow) | 1974-07-08 |
| DK133465B (da) | 1976-05-24 |
| DE1958226A1 (de) | 1970-05-27 |
| DE1958226C3 (de) | 1974-03-14 |
| CH529134A (de) | 1972-10-15 |
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