GB1247641A - 9alpha-FLUORO-16-FLUOROMETHYLENEPREDNISOLONE-21-ESTER AND PREPARATION THEREOF - Google Patents
9alpha-FLUORO-16-FLUOROMETHYLENEPREDNISOLONE-21-ESTER AND PREPARATION THEREOFInfo
- Publication number
- GB1247641A GB1247641A GB2720/70A GB272070A GB1247641A GB 1247641 A GB1247641 A GB 1247641A GB 2720/70 A GB2720/70 A GB 2720/70A GB 272070 A GB272070 A GB 272070A GB 1247641 A GB1247641 A GB 1247641A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dione
- reacting
- fluoro
- enanthate
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 9
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000004593 Epoxy Substances 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- JTDMDXUUHZZUGU-MMGCJVFTSA-N (8S,10S,13S,14S,17R)-17-ethyl-16-(fluoromethylidene)-10,13-dimethyl-3,6,7,8,12,14,15,17-octahydrocyclopenta[a]phenanthrene Chemical compound FC=C1[C@H](CC)[C@]2(CC=C3[C@]4(C=CCC=C4CC[C@H]3[C@@H]2C1)C)C JTDMDXUUHZZUGU-MMGCJVFTSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- UCVODTZQZHMTPN-UHFFFAOYSA-N heptanoyl chloride Chemical compound CCCCCCC(Cl)=O UCVODTZQZHMTPN-UHFFFAOYSA-N 0.000 abstract 1
- CUILPNURFADTPE-UHFFFAOYSA-N hypobromous acid Chemical compound BrO CUILPNURFADTPE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R4/00—Electrically-conductive connections between two or more conductive members in direct contact, i.e. touching one another; Means for effecting or maintaining such contact; Electrically-conductive connections having two or more spaced connecting locations for conductors and using contact members penetrating insulation
- H01R4/02—Soldered or welded connections
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R9/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, e.g. terminal strips or terminal blocks; Terminals or binding posts mounted upon a base or in a case; Bases therefor
- H01R9/22—Bases, e.g. strip, block, panel
- H01R9/28—Terminal boards
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1906586A DE1906586C3 (de) | 1969-02-11 | 1969-02-11 | 9 alpha-Fluor-16-fluormethylenprednisolon-21-önanthat, Verfahren zu seiner Herstellung und diese enthaltende pharmazeutische Zubereitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1247641A true GB1247641A (en) | 1971-09-29 |
Family
ID=5724819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2720/70A Expired GB1247641A (en) | 1969-02-11 | 1970-01-20 | 9alpha-FLUORO-16-FLUOROMETHYLENEPREDNISOLONE-21-ESTER AND PREPARATION THEREOF |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3681409A (enExample) |
| AT (3) | AT303277B (enExample) |
| BE (1) | BE745708A (enExample) |
| BR (1) | BR6915196D0 (enExample) |
| CH (1) | CH534673A (enExample) |
| DE (1) | DE1906586C3 (enExample) |
| DK (1) | DK123475B (enExample) |
| ES (1) | ES376409A1 (enExample) |
| FR (1) | FR2034535B1 (enExample) |
| GB (1) | GB1247641A (enExample) |
| HU (1) | HU165223B (enExample) |
| IL (1) | IL33812A (enExample) |
| NL (1) | NL7001197A (enExample) |
| PL (1) | PL80839B1 (enExample) |
| SE (1) | SE356744B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU572589B2 (en) | 1983-12-14 | 1988-05-12 | Upjohn Company, The | 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids |
| TW201914575A (zh) * | 2017-09-19 | 2019-04-16 | 大江生醫股份有限公司 | 地龍蛋白用於製造調理皮膚醫藥組成物之用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH405306A (de) * | 1959-02-10 | 1966-01-15 | Ciba Geigy | Verfahren zur Herstellung von Pregnadienverbindungen |
| DE1177151B (de) * | 1961-06-08 | 1964-09-03 | Merck Ag E | Verfahren zur Herstellung von 16-Chlormethylen- bzw. 16-Brommethylen-steroiden |
-
1969
- 1969-02-11 DE DE1906586A patent/DE1906586C3/de not_active Expired
- 1969-12-16 BR BR215196/69A patent/BR6915196D0/pt unknown
-
1970
- 1970-01-20 GB GB2720/70A patent/GB1247641A/en not_active Expired
- 1970-01-23 CH CH96870A patent/CH534673A/de not_active IP Right Cessation
- 1970-01-28 NL NL7001197A patent/NL7001197A/xx unknown
- 1970-01-30 IL IL33812A patent/IL33812A/xx unknown
- 1970-02-05 PL PL1970138626A patent/PL80839B1/pl unknown
- 1970-02-06 US US9408A patent/US3681409A/en not_active Expired - Lifetime
- 1970-02-09 SE SE01597/70A patent/SE356744B/xx unknown
- 1970-02-09 BE BE745708D patent/BE745708A/xx unknown
- 1970-02-10 AT AT00126/71A patent/AT303277B/de active
- 1970-02-10 ES ES376409A patent/ES376409A1/es not_active Expired
- 1970-02-10 AT AT125/71A patent/AT305503B/de not_active IP Right Cessation
- 1970-02-10 DK DK64370AA patent/DK123475B/da unknown
- 1970-02-10 AT AT120470A patent/AT298692B/de not_active IP Right Cessation
- 1970-02-11 FR FR707004757A patent/FR2034535B1/fr not_active Expired
- 1970-02-11 HU HUME1189A patent/HU165223B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT298692B (de) | 1972-05-25 |
| CH534673A (de) | 1973-03-15 |
| BE745708A (enExample) | 1970-08-10 |
| DE1906586B2 (de) | 1973-06-07 |
| DK123475B (da) | 1972-06-26 |
| IL33812A0 (en) | 1970-03-22 |
| AT305503B (de) | 1973-01-15 |
| NL7001197A (enExample) | 1970-08-13 |
| AT303277B (de) | 1972-10-15 |
| FR2034535B1 (enExample) | 1973-01-12 |
| HU165223B (enExample) | 1974-07-27 |
| IL33812A (en) | 1973-05-31 |
| ES376409A1 (es) | 1973-01-01 |
| DE1906586C3 (de) | 1974-01-03 |
| FR2034535A1 (enExample) | 1970-12-11 |
| BR6915196D0 (pt) | 1973-02-13 |
| PL80839B1 (enExample) | 1975-08-30 |
| DE1906586A1 (de) | 1970-11-05 |
| US3681409A (en) | 1972-08-01 |
| SE356744B (enExample) | 1973-06-04 |
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